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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for  Endogenous Metabolite

  1. Cat.No. 产品名称 Information
  2. GC62770 2-Amino-5-ureidopentanoic acid

    DL-瓜氨酸

     L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle.
  3. GC62769 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

    犬尿素

     2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种内源性代谢产物。
  4. GC62767 23,25-Dihydroxy-24-oxovitamin D3

    24-Oxo-23,25-dihydroxyvitamin D3

     23,25-Dihydroxy-24-oxovitamin D3 是 24(R),25-Dihydroxyvitamin D3 的主要代谢物。23,25-Dihydroxy-24-oxovitamin D3 可用于代谢性疾病的研究。
  5. GC62766 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate

    乳清酸

     2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 是一种内源性代谢产物。
  6. GC62763 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline

    2-(2’,3’,4’-Trihydroxybutyl)quinoxaline 是一种食物代谢物，可以由高葡聚糖形成。
  7. GC62758 13-cis-Vitamin A palmitate

    13-CIS维生素A棕榈酸酯,13-cis-Retinyl palmitate

     13 -cis-?retinyl hexadecanoate是十六烷酸的羧基与13-cis-retinol的羟基缩合而成的视黄酯,是由维生素A棕榈酸酯在玉米片中形成的13顺式异构体。13-顺式维生素 A 棕榈酸酯的生物活性是全反式维生素 A 棕榈酸酯的 75%，是维生素 A 中最具生物活性的形式。
  8. GC62755 1,4-D-Gulonolactone

    D-(-)-古洛糖酸-gamma-内酯

     1,4-D-Gulonolactone在易患坏血病、缺乏维生素 C 的动物（例如人类）中缺失。L-古洛糖酸内酯存在于人体血液中，已被用作比较运动引起的氧化应激变化的标志物之一。
  9. GC62751 (S)-Higenamine hydrobromide

    (S)-(-)-去甲乌药碱氢溴酸盐,(S)-Norcoclaurine hydrobromide

     (S)-Higenamine ((S)-Norcoclaurine) hydrobromide，Higenamine 的 S 型异构体，是苄基异喹啉生物碱生物合成的起始化合物，由去甲月桂碱合酶 (NCS) 将多巴胺和 4-羟基苯乙醛 (4-HPAA) 缩合生成。
  10. GC62749 (S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid

    L-GLYCERATE3-PHOSPHATE二钠盐

     (S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid 是一种内源性代谢产物。
  11. GC62748 (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate

    3,5-二碘-L-酪氨酸二水合物

     3,5-Diiodotyrosine Dihydrate (Iodogorgoic acid, apothyrin, jodgorgon) is a product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones.
  12. GC62747 (S)-(-)-Citronellal

    (-)-香茅醛; (-?)?-?Citronellal

     (-)-Citronellal, a constituent of citronella oil, is used in the synthesis of bioactive compounds.
  13. GC62734 (E)-Oct-2-enoic acid

    2-辛烯酸

     2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
  14. GC62731 (2R,3R)-Butane-2,3-diol

    (2R,3R)-(-)-2,3-丁二醇

     (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.
  15. GC62587 Simvastatin acid ammonium

    辛伐他汀铵盐; Tenivastatin ammonium

     An inhibitor of HMG-CoA reductase
  16. GC62537 Demethylcantharidate disodium

    内氧草索钠盐

     Demethylcantharidate disodium 是一种内源性代谢产物，通过内质网应激诱导肝癌细胞凋亡。Demethylcantharidate disodium 对多种类型的癌症具有良好的抗癌活性。
  17. GC62372 Cyclic-di-GMP sodium

    c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium

     A bacterial second messenger and cyclic dinucleotide
  18. GC62352 1,3-Butanediol

    1,3-丁二醇

     1,3-丁二醇（1,3-Butanediol）是一种有机化合物，该化合物是一种无色、苦乐参半的水溶性液体。它是丁二醇的四种常见结构异构体之一。1,3-丁二醇可用作降血糖剂。1,3-丁二醇可转化为β-羟基丁酸，作为脑代谢的底物。
  19. GC62198 c-di-AMP sodium

    c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate

     C-di-AMP是STING(刺激内质网的蛋白)的激动剂,通过与该跨膜蛋白结合,激活TBK3-IRF3信号通路,进而引发I型IFN和TNF的产生。
  20. GC62179 Cyclic ADP-ribose

    环二磷酸腺苷核酸糖,cADPR

     An endogenous Ca2+ mobilizer
  21. GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium是 NHC的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate tetrasodium是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。
  22. GC61956 NHC-diphosphate NHC-diphosphate 是 NHC 的活性胞内磷酸化代谢物 (intracellular metabolite )，以二磷酸盐的形式存在。NHC 是一种嘧啶核糖核苷，是一种有效的抗病毒剂 (anti-virus agent)。NHC 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制。
  23. GC61940 Cysteinylglycine TFA Cysteinylglycine TFA 是一种内源性代谢产物，用于疾病诊断。
  24. GC61932 Guanosine-5'-triphosphate disodium salt

    鸟苷-5'-三磷酸二钠盐,5'-GTP disodium salt

     An energy substrate for protein synthesis and gluconeogenesis
  25. GC61902 N-Formylglycine

    N-甲酰甘氨酸

     N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite.
  26. GC61863 Verucopeptin Verucopeptin 是一种有效的 HIF-1 (IC50=0.22 µM) 抑制剂，可以降低 HIF-1 靶基因的表达和 HIF-1α 的蛋白水平。通过直接靶向 v-ATPase ATP6V1G 亚基 (但不靶向 ATP1V1B2 或 ATP6V1D)，Verucopeptin 强烈抑制 v-ATPase 活性。Verucopeptin 对耐药性癌细胞表现出抗肿瘤活性，常用作癌症相关研究。
  27. GC61862 3'-Deoxyuridine-5'-triphosphate trisodium

    3'-dUTP trisodium

     3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) 是一种核苷酸类似物，可抑制 DNA 依赖性 RNA 聚合酶 I 和 II (RNA polymerases I 和 II)，强烈并竞争性地抑制 UTP 掺入到 RNA 中，Ki 值为 2.0 µM。
  28. GC61839 Ternidazole hydrochloride

    特尼达唑

     Ternidazole hydrochloride 是硝基咪唑的羟基代谢物 (hydroxymetabolite)，具有抗氧化活性。
  29. GC61830 NADH disodium salt

    beta-烟酰胺腺嘌呤二核苷二钠,Disodium NADH

     NADH disodium salt是烟酰胺腺嘌呤二核苷酸磷酸(NADH)的一种钠盐形式,NADH是一种辅酶,在细胞能量代谢中作为再生电子供体,包括糖酵解、β氧化和柠檬酸循环。
  30. GC19750 alpha-L-Rhamnose

    L-鼠李糖; L-Rhamnose

     Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level
  31. GC19749 Maleamic acid

    马来酰胺酸,Acrylic acid

     马来酸是一种内源性代谢物。
  32. GC61797 L-Palmitoylcarnitine TFA L-PalmitoylcarnitineTFA是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-PalmitoylcarnitineTFA通过与Kir6.2的相互作用抑制KATP通道活性，而不影响单通道电导。
  33. GC61792 Cyclic ADP-ribose ammonium

    cADPR ammonium

     An endogenous Ca2+ mobilizer
  34. GC61759 (R)-3-Hydroxybutanoic acid sodium

    (R)-(-)-3-羟基丁酸钠盐; (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium

     (R)-3-Hydroxybutanoicacidsodium((R)-3-Hydroxybutyricacid)是一种代谢物，由3-羟基丁酸脱氢酶催化乙酸乙酯获得。(R)-3-Hydroxybutanoicacidsodium可作为营养来源和维生素、抗生素和信息素的前体。
  35. GC61736 D-Ribose 5-phosphate disodium dihydrate

    D-核糖-5-磷酸二钠盐

     D-Ribose5-phosphatedisodiumdihydrate是戊糖磷酸途径(PPP)氧化分支的中间产物，是PPP非氧化分支的最终产物。D-Ribose5-phosphate用于核苷酸和核酸的合成。
  36. GC61716 3,5-Dimethylbenzaldehyde

    3,5-二甲基苯甲醛

     3,5-Dimethylbenzaldehyde是一种化学合成中的分子砌块。
  37. GC61703 DL-Glutamic acid

    DL-谷氨酸

     DL-谷氨酸是作为基本代谢产物的谷氨酸的共轭酸。与多晶型物α和βL-谷氨酸的第二相相比，DL-谷氨酸具有更好的稳定性。
  38. GC61695 L-Uridine

    L-尿苷

     L-Uridine分离自PolyporaceaefungusPoriacocos(Schw.)，是正常RNA成分中的D-尿苷的对映异构体。L-Uridine充当核苷磷酸转移酶的磷酸受体。
  39. GC61691 Arabinose

    DL-阿拉伯糖; (±)-Arabinose; DL-Arabinose; dl-Arabinose

     Arabinose是一种内源性代谢产物。
  40. GC61647 (+)-Longifolene

    长叶烯

     (+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins
  41. GC61614 Succinyladenosine

    N6-Succinyl adenosine

     Succinyladenosine，是胞内腺苷酸(S-AMP)经5-核苷酸酶脱磷酸化的产物，是腺苷酸琥珀酸酶(ASL)缺乏的生化标志。
  42. GC61604 Guanylin(human) TFA Guanylin(human)TFA，一种15个氨基酸的肽，是一种内源性肠鸟苷酸环化酶(intestinalguanylatecyclase)激活剂。Guanylin(human)TFA主要存在于胃肠道中，其通过cGMP依赖性机制调节肠和肾上皮中电解质水的运输。
  43. GC61538 11-Oxo etiocholanolone

    11-酮本胆烷醇酮,11-Ketoetiocholanolone

     11-oxo Etiocholanolone 是皮质醇和 11-酮睾酮的代谢产物。由皮质醇经可的松和四氢可的酮中间体形成，由11-酮睾酮经5β-11-酮二氢睾酮和3α-11-酮基胆二醇中间体形成.?妊娠期间 11-氧代胆烷醇酮的尿液水平升高，并且在子宫平滑肌瘤患者中升高。11-氧代胆烷醇酮的粪便水平已被用作家畜和散养反刍动物压力的标志物。
  44. GC61496 Angiotensin (1-7) (acetate)

    Ang-(1-7) (acetate)

     Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
  45. GC61494 D-Sedoheptulose 7-phosphate An intermediate in the pentose phosphate pathway
  46. GC61487 all-trans-Anhydro Retinol

    全反式-脱水视黄醇,Anhydrovitamin A

     all-trans-AnhydroRetinol(AnhydrovitaminA)是维生素A的代谢产物。all-trans-AnhydroRetinol用于合成的多种维生素制剂。
  47. GC61482 sn-Glycerol 3-phosphate lithium sn-Glycerol3-phosphatelithium是由胞质甘油3-磷酸脱氢酶途径产生的，利用糖酵解过程中形成的NADH减少二羟丙酮磷酸。
  48. GC61460 Dihydroxyacetone phosphate hemimagnesium hydrate Dihydroxyacetonephosphate在脂质生物合成和糖酵解中是重要的中间产物。它是一种参与多种代谢途径的生化化合物，包括植物的卡尔文循环和糖酵解。Dihydroxyacetonephosphate被发现与醛缩酶缺乏有关，这是一种先天性代谢错误。
  49. GC61448 ATP disodium trihydrate

    腺苷三磷酸二钠三水合物; Adenosine-5'-triphosphate disodium trihydrate

     ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.
  50. GC61443 Thiamine monophosphate chloride (dihydrate)

    3-[(4-氨基-2-甲基-5-嘧啶基)甲基]-4-甲基-5-[2-(膦酰氧基)乙基]-噻唑氯化物二水合物

     Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) is an endogenous metabolite.
  51. GC61442 1-Methylguanidine hydrochloride

    1-甲基胍盐酸盐

     Methylguanidine is a guanidine compound deriving from protein catabolism.

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