EGFR(表皮生长因子受体)
EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.
Products for EGFR
- Cat.No. 产品名称 Information
- GC41577 Tephrosin (synthetic) An antineoplastic and piscicidal rotenoid
- GC40915 PKI-166 An inhibitor of EGFR
- GC34847 TX1-85-1 An ErbB3 inhibitor
- GC19509 Gefitinib-based PROTAC 3 A PROTAC that drives mutant EGFR degradation
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GC34217
Cetuximab (C225)
Cetuximab (C225) (C225) 是一种人 IgG1 单克隆抗体,可抑制表皮生长因子受体 (EGFR),SPR 对 EGFR 的 Kd 为 0.201 nM。西妥昔单抗 (C225) 具有有效的抗肿瘤活性。
- GC34215 Trastuzumab (Anti-Human HER2, Humanized Antibody) 曲妥珠单抗(Anti-Human HER2, Humanized Antibody)是一种人源化 IgG1 单克隆抗体,适用于过度表达 HER2 的浸润性乳腺癌患者。曲妥珠单抗(抗人 HER2,人源化抗体)具有用于 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌研究的潜力。
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GC34210
Pertuzumab (Anti-Human HER2, Humanized Antibody)
帕妥珠单抗(抗人 HER2,人源化抗体)是指定为 HER 二聚化抑制剂的新型药物中的第一个,是一种人源化 IgG1 单克隆抗体 (mAb),可空间结合 erbB2 受体的结构域 II。
- GC34105 PD153035 Hydrochloride (ZM 252868) A highly potent EGFR inhibitor
- GC33195 EGFR-IN-2 EGFR-IN-2是一种非共价的,不可逆的,突变选择性的二代EGFR抑制剂。
- GC33172 BGB-102 (JNJ-26483327) BGB-102 (JNJ-26483327) 是一种有效的多激酶抑制剂,针对 EGFR、HER2 和 HER4,IC50 分别为 9.6 nM、18 nM 和 40.3 nM。
- GC33171 ZD-4190 ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.
- GC33131 NRC-2694 NRC-2694是一种表皮生长因子受体(EGFR)拮抗剂,具有抗癌、抗增殖的活性。
- GC33096 AST2818 mesylate An inhibitor of mutant EGFRs
- GC33061 Rociletinib hydrobromide (CO-1686 (hydrobromide)) Rociletinib hydrobromide (CO-1686 (hydrobromide)) (CO-1686 hydrobromide) 是一种口服激酶抑制剂,特异性靶向 EGFR 的突变形式,包括 T790M,EGFRL858R/T790M 和 EGFRWT 的 Ki 值为 21.5 nM 和 303.3 nM,分别。
- GC33053 HS-10296 hydrochloride Almonertinib (HS-10296) hydrochloride 是一种口服的、不可逆的第三代 EGFR 酪氨酸激酶抑制剂,对 EGFR 致敏和 T790M 耐药突变具有高选择性。 HS-10296 hydrochloride 对 T790M、T790M/L858R 和 T790M/Del19 具有很强的抑制活性(IC50 分别为 0.37、0.29 和 0.21 nM),而对野生型的抑制效果较差(3.39 nM)。 HS-10296 hydrochloride 用于非小细胞肺癌的研究。
- GC33048 Epertinib (S-22611) Epertinib (S-22611) (S-22611) 是一种有效的、口服的、可逆的、选择性的 EGFR、HER2 和 HER4 酪氨酸激酶抑制剂,IC50 分别为 1.48 nM、7.15 nM 和 2.49 nM。 Epertinib (S-22611) 显示出有效的抗肿瘤活性。
- GC33022 Naquotinib (ASP8273) An irreversible inhibitor of mutant EGFRs
- GC32989 Pyrotinib dimaleate (SHR-1258 dimaleate) Pyrotinib (SHR-1258, BLTN, Pyrroltinib) dimaleate is a potent and selective irreversible dual tyrosine kinase inhibitor of EGFR and HER2 with IC50 of 0.013 μM and 0.038 μM, respectively.
- GC32927 PF-06459988 PF-06459988是T790M-ContainingEGFRMutants不可逆性抑制剂。
- GC32836 Naquotinib mesylate (ASP8273) An irreversible inhibitor of mutant EGFRs
- GC32752 TAS6417 TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.
- GC32733 Pyrotinib (SHR-1258) Pyrotinib (SHR-1258) (SHR-1258) 是一种有效的选择性 EGFR/HER2 双重抑制剂,IC50 分别为 13 和 38 nM。
- GC32726 Tucatinib (Irbinitinib) An inhibitor of HER2
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GC32100
Tarloxotinib bromide (TH-4000)
Tarloxotinib bromide (TH-4000) (TH-4000) 是一种不可逆的 EGFR/HER2 抑制剂。
- GC31752 Tesevatinib (XL-647) A multi-kinase inhibitor
- GC19364 Tyrphostin AG 528 A tyrphostin that inhibits EGFR and HER2
- GC19256 MTX-211 MTX-211 (Mol 211) 是 EGFR 和 PI3K 的双重抑制剂,IC50 值 <100 nM。 MTX-211可用于癌症和其他疾病的研究。
- GC19218 Lazertinib An irreversible inhibitor of mutant EGFRs
- GC19132 EGFR-IN-3 EGFR-IN-3 是第三代 EGFR TKI,GI50 值分别为 5 nM (EGFR L858R/T790M)、10 nM (EGFR del19) 和 689 nM (EGFR WT)。 EGFR-IN-3 具有用于 NSCLC 研究的潜力。
- GC19066 BGB-283 BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
- GC19044 Avitinib maleate A selective inhibitor of mutant EGFR
- GC12864 AG-1557 An EGFR inhibitor
- GC10217 RG-14620 An inhibitor of EGF receptor kinase
- GC14103 NSC228155 An EGFR activator and inhibitor of KID-KIX interactions
- GC15370 Olmutinib (HM61713, BI 1482694) An inhibitor of mutant EGFR
- GC12038 RG 13022 An inhibitor of EGF receptor kinase
- GC12281 EAI045 A potent inhibitor of mutant EGFRs
- GC13143 AZD3759 A brain penetrant inhibitor of EGFR
- GC17790 CL-387785 (EKI-785) An irreversible inhibitor of EGFR kinase activity
- GC16321 EGF816 An inhibitor of mutant EGFR
- GC12955 AZ5104 An active metabolite of AZD 9291
- GC17916 Poziotinib An inhibitor of EGFRs
- GC13213 WZ3146 An inhibitor of mutant EGFR
- GC15950 CGP 52411 A phthalimide with diverse biological activities
- GC15925 PD 158780 An ErbB receptor family inhibitor
- GC13168 AG 825 An inhibitor of Her2/Neu tyrosine kinase activity
- GC11744 AG 555 A tyrphostin EGFR inhibitor
- GC14494 AG 99 An inhibitor of EGF receptor kinase
- GC16021 Lavendustin A A selective inhibitor of EGF receptor-associated tyrosine kinase
- GC15271 Tyrphostin AG 879 A non-specific tyrphostin ErbB2 inhibitor