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Mobocertinib succinate Sale

(Synonyms: 莫博替尼琥珀酸盐; TAK-788 succinate; AP32788 succinate) 目录号 : GC62160

An inhibitor of mutant EGFR and HER2 receptors

Mobocertinib succinate Chemical Structure

Cas No.:2389149-74-8

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥396.00
现货
10 mg
¥360.00
现货
25 mg
¥675.00
现货
50 mg
¥1,170.00
现货
100 mg
¥1,890.00
现货
500 mg
¥7,020.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors.1,2 It is selective for the HER2 exon 20 mutants HER2V659E, HER2G660D, HER2G309E, and HER2S310F over wild-type EGFR in Ba/F3 cells.1

1.Chouitar, J., Vincent, S., Brake, R., et al.TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2AbstractsS811P2(13-32)(2018) 2.Neal, J., Doebele, R., Riely, G., et al.Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLCAbstractsS599P1(13-44)(2018)

Chemical Properties

Cas No. 2389149-74-8 SDF
别名 莫博替尼琥珀酸盐; TAK-788 succinate; AP32788 succinate
分子式 C36H45N7O8 分子量 703.78
溶解度 DMSO : 25 mg/mL (35.52 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.4209 mL 7.1045 mL 14.209 mL
5 mM 0.2842 mL 1.4209 mL 2.8418 mL
10 mM 0.1421 mL 0.7104 mL 1.4209 mL
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Research Update

Discovery, Development, Inventions, and Patent Trends on Mobocertinib succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions

Biomedicines 2021 Dec 17;9(12):1938.PMID:34944754DOI:10.3390/biomedicines9121938.

The majority of lung cancers are non-small-cell lung cancer (NSCLC) having a low survival rate. Recent studies have indicated the involvement of epidermal growth factor receptor (EGFR) oncogene mutations like EGFR exon 20 insertions (EGFRex20ins) mutation among NSCLC patients. The response of patients of NSCLC with the EGFRex20ins mutation to the currently available EGFR inhibitor is negligible. Mobocertinib is the first oral treatment that has been approved by the USFDA, on 15 September 2021, to treat NSCLC with the EGFRex20ins mutation. This patent review discusses the inventions and patent literature of mobocertinib that will help the scientific community to develop additional and improved inventions related to mobocertinib. The structure of mobocertinib was first reported in 2015. Therefore, this article covered the patents/patent applications related to mobocertinib from 2015 to 25 October 2021. The patent search revealed 27 patents/patent applications related to compound, method of treatment, salt, polymorph, process, composition, and drug combinations of mobocertinib. The authors foresee an exciting prospect for developing a treatment for NSCLC with EGFRex20ins mutation, and other cancers employing a combination of mobocertinib with other approved anticancer agents. The inventions related to novel dosage forms, processes, and intermediates used in the synthesis of mobocertinib are also anticipated.