EGFR(表皮生长因子受体)

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

Products for EGFR

Cat.No. 产品名称 Information
GC10250 Mubritinib (TAK 165) A selective inhibitor of HER2
GC13854 AG-490 (Tyrphostin B42) AG-490是EGFR抑制剂,IC50为0.1 µM, AG-490对JAK2也有抑制作用。.
GC16698 AZD-9291 mesylate
An inhibitor of mutant EGFR
GC16308 AZD-9291
An inhibitor of mutant EGFR
GC17982 Icotinib An EGFR inhibitor
GC11126 Mutant EGFR inhibitor Mutant EGFR inhibitor 是从专利WO 2013014448 A1中提取的一种有效的选择性突变EGFR抑制剂；抑制 EGFRL858R、EGFRExon 19 缺失和 EGFRT790M。
GC15669 AST-1306 TsOH An irreversible inhibitor of EGFR, HER2, and HER4
GC17530 OSI-420 OSI-420 (OSI-420) 是厄洛替尼的活性代谢物。厄洛替尼是一种有效的 EGFR 酪氨酸激酶抑制剂。
GC11264 CNX-2006 An irreversible inhibitor of mutant EGFRs
GC16000 WHI-P180 A multi-kinase inhibitor
GC11172 TAK-285 A dual inhibitor of EGFR and HER2
GC13761 AZD8931 (Sapitinib) A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3
GC11691 AST-1306 An irreversible inhibitor of EGFR, HER2, and HER4
GC12478 ARRY-380 An inhibitor of EGFR
GC12249 Varlitinib (ARRY334543) An inhibitor of EGFR and HER2
GC17226 AG-1478 An inhibitor of EGF receptor kinase
GC10362 Neratinib (HKI-272) A dual inhibitor of EGFR and HER2
GC10225 Dacomitinib (PF299804, PF299) A pan-ErbB receptor tyrosine kinase inhibitor
GC17283 AP26113 A potent ALK inhibitor
GC10944 Butein A plant polyphenol
GC17647 AG-18 An inhibitor of EGF receptor kinase
GC11015 PD168393 An irreversible EGFR kinase inhibitor
GC11892 AEE788 (NVP-AEE788) An inhibitor of EGFR and VEGFR tyrosine kinases
GC12910 Canertinib (CI-1033) Canertinib (CI-1033) (CI-1033;PD-183805) 是一种有效且不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自磷酸化，IC50 为 7.4 和 9 nM。
GC13257 AC480 (BMS-599626) A dual inhibitor of EGFR and HER2
GC11250 WZ8040 An inhibitor of mutant EGFR
GC17473 Pelitinib (EKB-569) An EGFR receptor tyrosine kinase inhibitor
GC13091 CP-724714 A selective HER2/ErbB2 tyrosine kinase inhibitor
GC15494 WZ4002 A potent inhibitor of EGFR-T790M kinase activity
GC14102 Genistein An isoflavonoid phytoestrogen
GC13296 Afatinib(BIBW2992) A selective dual inhibitor of EGFR/HER2
GC15600 Erlotinib Hydrochloride An EGFR tyrosine kinase inhibitor
GC16737 Gefitinib (ZD1839) 吉非替尼(ZD1839)是一种强效的表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI),IC50为0.033 µM,能选择性抑制表皮生长因子刺激的肿瘤细胞生长,IC50为0.054 µM,并能阻断表皮生长因子刺激的表皮生长因子受体(EGFR)在肿瘤细胞中的自身磷酸化。.
GC13608 Lapatinib A dual inhibitor of EGFR and ErbB2
GC16593 Lapatinib Ditosylate Lapatinib Ditosylate (GW572016 ditosylate monohydrate) 是有效的 ErbB-2 和 EGFR 酪氨酸激酶结构域抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC50 值分别为 10.2 和 9.8 nM。
GC16244 Icotinib Hydrochloride An EGFR inhibitor
GC14295 Gefitinib hydrochloride An EGFR inhibitor
GC10627 Erlotinib An EGFR tyrosine kinase inhibitor
GC14695 CO-1686 (AVL-301) A selective inhibitor of mutant EGFR
GC12087 Canertinib dihydrochloride A pan-ErbB tyrosine kinase inhibitor
GC13873 BMS-690514 BMS-690514 是一种有效的、具有口服活性的 EGFR 和 VEGFR 抑制剂；对 EGFR、HER 2 和 HER 4 的 IC50 分别为 5、20 和 60 nM。
GC10606 BMS-599626 Hydrochloride BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种选择性的口服生物可利用的 HER1 和 HER2 抑制剂，IC50 分别为 20 和 30 nM。 BMS-599626 Hydrochloride 对 HER4 (IC50=190 nM) 的效力降低约 8 倍，对 VEGFR2、c-Kit、Lck、MEK 的效力超过 100 倍。 BMS-599626 Hydrochloride 抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。
GC10087 BIBX 1382 An EGFR inhibitor
GC10707 Afatinib dimaleate An inhibitor of EGFR and ErbB2
GC15589 WHI-P154 A JAK3 inhibitor
GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2
GC15983 PD 153035 hydrochloride A highly potent EGFR inhibitor
GC12837 Compound 56 A potent EGFR inhibitor
GN10327 Chrysophanol An anthraquinone with diverse biological activities
GN10336 Daphnetin A coumarin derivative with diverse biological activities