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Home >> Signaling Pathways >> JAK/STAT Signaling

JAK/STAT Signaling(JAK/STAT 信号通路)

Products for  JAK/STAT Signaling

  1. Cat.No. 产品名称 Information
  2. GC15669 AST-1306 TsOH An irreversible inhibitor of EGFR, HER2, and HER4
  3. GC17530 OSI-420 OSI-420 (OSI-420) 是厄洛替尼的活性代谢物。厄洛替尼是一种有效的 EGFR 酪氨酸激酶抑制剂。
  4. GC11264 CNX-2006 An irreversible inhibitor of mutant EGFRs
  5. GC16000 WHI-P180 A multi-kinase inhibitor
  6. GC11172 TAK-285 A dual inhibitor of EGFR and HER2
  7. GC13761 AZD8931 (Sapitinib) A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3
  8. GC11691 AST-1306 An irreversible inhibitor of EGFR, HER2, and HER4
  9. GC12478 ARRY-380 An inhibitor of EGFR
  10. GC12249 Varlitinib (ARRY334543) An inhibitor of EGFR and HER2
  11. GC17226 AG-1478 An inhibitor of EGF receptor kinase
  12. GC14653 NSC 74859 A STAT3 inhibitor
  13. GC10362 Neratinib (HKI-272) A dual inhibitor of EGFR and HER2
  14. GC10225 Dacomitinib (PF299804, PF299) A pan-ErbB receptor tyrosine kinase inhibitor
  15. GC15134 Fludarabine Phosphate (Fludara) A prodrug form of fludarabine and 2-fluoro-ara-ATP
  16. GC17283 AP26113 A potent ALK inhibitor
  17. GC10944 Butein A plant polyphenol
  18. GC17647 AG-18 An inhibitor of EGF receptor kinase
  19. GC17886 Stattic

    A small molecule inhibitor of STAT3
  20. GC11015 PD168393 An irreversible EGFR kinase inhibitor
  21. GC11892 AEE788 (NVP-AEE788) An inhibitor of EGFR and VEGFR tyrosine kinases
  22. GC14144 Fludarabine An intermediate active metabolite of fludarabine
  23. GC12910 Canertinib (CI-1033) Canertinib (CI-1033) (CI-1033;PD-183805) 是一种有效且不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自磷酸化，IC50 为 7.4 和 9 nM。
  24. GC13257 AC480 (BMS-599626) A dual inhibitor of EGFR and HER2
  25. GC11250 WZ8040 An inhibitor of mutant EGFR
  26. GC17473 Pelitinib (EKB-569) An EGFR receptor tyrosine kinase inhibitor
  27. GC13091 CP-724714 A selective HER2/ErbB2 tyrosine kinase inhibitor
  28. GC15494 WZ4002 A potent inhibitor of EGFR-T790M kinase activity
  29. GC14102 Genistein An isoflavonoid phytoestrogen
  30. GC17621 TPCA-1 A selective inhibitor of IKK2
  31. GC13296 Afatinib(BIBW2992) A selective dual inhibitor of EGFR/HER2
  32. GC15600 Erlotinib Hydrochloride An EGFR tyrosine kinase inhibitor
  33. GC16737 Gefitinib (ZD1839) 吉非替尼(ZD1839)是一种强效的表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI),IC50为0.033 µM,能选择性抑制表皮生长因子刺激的肿瘤细胞生长,IC50为0.054 µM,并能阻断表皮生长因子刺激的表皮生长因子受体(EGFR)在肿瘤细胞中的自身磷酸化。.
  34. GC13608 Lapatinib A dual inhibitor of EGFR and ErbB2
  35. GC16593 Lapatinib Ditosylate Lapatinib Ditosylate (GW572016 ditosylate monohydrate) 是有效的 ErbB-2 和 EGFR 酪氨酸激酶结构域抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC50 值分别为 10.2 和 9.8 nM。
  36. GC17762 NSC 33994 NSC 33994 (G6) 是一种选择性 JAK2 抑制剂，IC50 为 60 nM。
  37. GC17178 TCS PIM-1 1 A Pim-1 kinase inhibitor
  38. GC13488 R8-T198wt R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽，通过抑制 Pim-1 激酶表现出抗肿瘤活性。
  39. GC13558 PIM-1 Inhibitor 2 A potent PIM-1 kinase inhibitor
  40. GC15125 ZM 449829 An inhibitor of JAK3
  41. GC16584 TCS 21311 A JAK3 inhibitor
  42. GC12118 SD 1008

    SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。
  43. GC17033 Lestaurtinib A potent JAK2 and PRK1 kinase inhibitor
  44. GC13347 Cucurbitacin I An inhibitor STAT3/JAK signaling
  45. GC15391 Cercosporamide A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms
  46. GC17055 1,2,3,4,5,6-Hexabromocyclohexane 1,2,3,4,5,6-六溴环己烷（1,2,3,4,5,6-Hexabromocyclohexane）直接抑制JAK2激酶结构域内的口袋，抑制自身磷酸化。
  47. GC12660 AZD1208 A pan-Pim kinase inhibitor
  48. GC14327 XL019 A potent, bioavailable JAK2 inhibitor
  49. GC15956 WHI-P97 WHI-P97 是一种有效的选择性 JAK-3 抑制剂。
  50. GC12064 SB1317 A multi-kinase inhibitor
  51. GC16124 Ruxolitinib phosphate A potent and selective JAK1/JAK2 inhibitor

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