Home>>Peptides>>FSL-1 TFA

FSL-1 TFA Sale

目录号 : GC60860

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

FSL-1 TFA Chemical Structure

规格 价格 库存 购买数量

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.


Quality Control & SDS

View current batch:


FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6).1,2 In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-κB activity by 4- and 8-fold when used at concentrations of 0.1 and 1 nM, respectively.1 It induces the expression of the cytokines CCL20, IL-8, IL-1β, and TNF-α in human monocytic THP-1 cells and, to a lesser extent, in TLR10 knockdown cells when used at a concentration of 100 ng/ml.3 FSL-1 (0.5-50 μg/ml), in combination with IFN-γ, dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing the chemokine CXCL10 with a maximal increase of approximately 50%.4 In rats, FSL-1 (100 μg/kg, i.p.) induces fever and increases plasma levels of IL-6 and TNF-α by greater than 90-fold.5 FSL-1 (10-1,000 μg/kg, i.p.) also dose-dependently reduces home cage locomotor activity and both food and water consumption with maximal reductions of ten grams per 12 hours.
1.Okusawa, T., Fujita, M., Nakamura, J., et al.Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6Infect. Immun.72(3)1657-1665(2004) 2.Farhat, K., Riekenberg, S., Heine, H., et al.Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signalingJ. Leukoc. Biol.83(3)692-701(2008) 3.Le, H.V., and Kim, J.Y.Stable Toll-Like Receptor 10 Knockdown in THP-1 Cells Reduces TLR-Ligand-Induced Proinflammatory Cytokine ExpressionInt. J. Mol. Sci.17(6)E859(2016) 4.Mauldin, I.S., Wang, E., Deacon, D.H., et al.TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10Int. J. Cancer137(6)1386-1396(2015) 5.HÜbschle, T., MÜtze, J., MÜhlradt, P.F., et al.Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1Am. J. Physiol. Regul. Integr. Comp. Physiol.290(1)R180-R187(2006)

Chemical Properties

Cas No. SDF
分子式 C82H141F3N14O20S 分子量 1780.18
溶解度 H2O : 50 mg/mL (28.09 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。


1 mg 5 mg 10 mg
1 mM 0.5617 mL 2.8087 mL 5.6174 mL
5 mM 0.1123 mL 0.5617 mL 1.1235 mL
10 mM 0.0562 mL 0.2809 mL 0.5617 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。


动物体内配方计算器 (澄清溶液)

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
% DMSO % % Tween 80 % saline