MMP(基质金属蛋白酶)
- Cat.No. 产品名称 Information
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GC64535
(S,S)-TAPI-1
A TACE inhibitor
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GC45978
1,10-Phenanthroline (hydrate)
A metal chelator and inhibitor of metalloproteases
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GC46769
Abametapir
A building block and an insecticide
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GC63661
Aderbasib
Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性,可用于癌症研究,包括弥漫性大 B 细胞非霍奇金淋巴瘤,HER2+ 乳腺癌,胶质瘤等。
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GC68656
Andecaliximab
Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化疗效。Andecaliximab 可用于胃腺癌和特发性肺纤维化 (IPF) 的研究。
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GC62347
CMC2.24
CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂,通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂,IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。
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GC60114
CTTHWGFTLC, CYCLIC TFA
CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
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GC68925
cyclo(RLsKDK) TFA
cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8 抑制剂,IC50 值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
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GC63621
Doxycycline
Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
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GC62948
Edaravone D5
Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。
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GC60860
FSL-1 TFA
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
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GC39640
GPLGIAGQ TFA
GPLGIAGQ TFA 是一种 MMP2 可切割的多肽,在脂质体和胶束纳米载体中都被用作刺激敏感的连接物,用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。
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GC48421
GW 280264X
An ADAM17/TACE and ADAM10 inhibitor
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GC39134
Isofraxidin
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
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GC39095
Isoliquiritin apioside
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
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GP21929
MMP 1 Human
基质金属蛋白酶-1 人重组体
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GP21928
MMP 1 Human, HEK
Matrix Metalloproteinase-1 Human Recombinant, HEK
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GP21932
MMP 13 Human
Matrix Metalloproteinase-13 Human Recombinant
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GP21936
MMP 3 Human
Matrix Metalloproteinase-3 Human Recombinant
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GP21935
MMP 3 Human, GST
Matrix Metalloproteinase-3 Human Recombinant, GST Tag
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GP21934
MMP 3 Human, HEK
Matrix Metalloproteinase-3 Human Recombinant, HEK
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GP21938
MMP 7 Human
Matrix Metalloproteinase-7 Human Recombinant
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GP21937
MMP 7 Human, Active
Matrix Metalloproteinase-7 Human Recombinant, Active
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GP21939
MMP 8 Human
Matrix Metalloproteinase-8 Human Recombinant
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GP21940
MMP 8 Human, His
Matrix Metalloproteinase-8 Human Recombinant, His Tag
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GP21941
MMP 9 Human
基质金属蛋白酶 9 人重组体
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GP21946
MMP 9 Rabbit
Matrix Metalloproteinase-9 Rabbit Recombinant
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GP25563
MMP-2 Human, HEK
Matrix Metalloproteinase-2 Human Recombinant, HEK
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GC69480
MMP-7-IN-1
MMP-7-IN-1 是一种有效的、选择性 MMP-7 抑制剂 (IC50=10 nM),而对 MMP-1, -2, -3, -8, -9, -13 的 IC50>11 mM。MMP-7 是癌症和纤维化等疾病的潜在靶点。
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GP21931
MMP1 (24-207) Human
Matrix Metalloproteinase-1 (24-207 a.a) Human Recombinant, HEK
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GP21930
MMP1 Human, sf9
Matrix Metalloproteinase-1 Human Recombinant, sf9
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GP21947
MMP10 Human
Matrix Metallopeptidase 10 Human Recombinant
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GC65957
MMP13-IN-2
MMP13-IN-2 是一种有效、选择性和口服活性的 MMP-13 抑制剂。MMP13-IN-2 对 MMP-13 具有优异的效价 (IC50=0.036 nM),对 MMP-1、3、7、8、9、14 和 TACE 的选择性(大于 1500 倍)。MMP13-IN-2 在体外具有阻止软骨释放胶原蛋白的能力。MMP13-IN-2 具有胶原酶相关疾病研究的潜力。
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GC63322
MMP13-IN-3
An inhibitor of MMP-13
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GP21950
MMP14 Human
Matrix Metalloproteinase-14 Human Recombinant
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GP29001
MMP14 Human, His
MMP14 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 527 amino acids (21-538a
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GP21933
MMP2 Human
基质金属蛋白酶 2 人重组体
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GP26167
MMP2 Mouse
MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
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GC69479
MMP2-IN-1
MMP2-IN-1 是一种中度有效的 MMP2 抑制剂,IC50 为 6.8 µM。MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡 (apoptosis),在某些癌细胞中表现出显著的抗增殖活性。
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GP21948
MMP23B Human
Matrix Metallopeptidase 23B Human Recombinant
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GP21949
MMP28 Human
Matrix Metalloproteinase-28 Human Recombinant
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GP21942
MMP9 Human, HEK
Matrix Metalloproteinase-9 Human Recombinant, HEK
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GP21943
MMP9 Human, Sf9
Matrix Metalloproteinase-9 Human Recombinant, Sf9
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GP26168
MMP9 Mouse
MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
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GC69554
NFF-3 TFA
NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3 和 MMP-10 而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA,可在细胞实验中产生荧光,而检测细胞活性。
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GC63132
Otaplimastat
Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂,以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。
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GP21944
ProMatrilysin
ProMatrix Metalloproteinase-7 Recombinant
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GP21945
ProMMP 9 Human
Pro-Matrix Metalloproteinase-9 Human Recombinant
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GC46220
SD 2590 (hydrochloride)
An MMP inhibitor
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GC50353
T 26c disodium salt
A selective inhibitor of MMP-13