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Home >> Proteins >> Enzymes >> MMP

MMP(基质金属蛋白酶)

  1. Cat.No. 产品名称 Information
  2. GC64535 (S,S)-TAPI-1 A TACE inhibitor
  3. GC45978 1,10-Phenanthroline (hydrate) A metal chelator and inhibitor of metalloproteases
  4. GC46769 Abametapir A building block and an insecticide
  5. GC63661 Aderbasib Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性，可用于癌症研究，包括弥漫性大 B 细胞非霍奇金淋巴瘤，HER2+ 乳腺癌，胶质瘤等。
  6. GC68656 Andecaliximab Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化疗效。Andecaliximab 可用于胃腺癌和特发性肺纤维化 (IPF) 的研究。
  7. GC62347 CMC2.24 CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂，通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂，IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。
  8. GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
  9. GC68925 cyclo(RLsKDK) TFA cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8 抑制剂，IC50 值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
  10. GC63621 Doxycycline

    Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
  11. GC62948 Edaravone D5 Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂，能够抑制大鼠与 MMP-9 有关的脑出血。
  12. GC60860 FSL-1 TFA

    FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
  13. GC39640 GPLGIAGQ TFA

    GPLGIAGQ TFA 是一种 MMP2 可切割的多肽，在脂质体和胶束纳米载体中都被用作刺激敏感的连接物，用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。
  14. GC48421 GW 280264X An ADAM17/TACE and ADAM10 inhibitor
  15. GC39134 Isofraxidin Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
  16. GC39095 Isoliquiritin apioside Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
  17. GP21929 MMP 1 Human 基质金属蛋白酶-1 人重组体
  18. GP21928 MMP 1 Human, HEK Matrix Metalloproteinase-1 Human Recombinant, HEK
  19. GP21932 MMP 13 Human Matrix Metalloproteinase-13 Human Recombinant
  20. GP21936 MMP 3 Human Matrix Metalloproteinase-3 Human Recombinant
  21. GP21935 MMP 3 Human, GST Matrix Metalloproteinase-3 Human Recombinant, GST Tag
  22. GP21934 MMP 3 Human, HEK Matrix Metalloproteinase-3 Human Recombinant, HEK
  23. GP21938 MMP 7 Human Matrix Metalloproteinase-7 Human Recombinant
  24. GP21937 MMP 7 Human, Active Matrix Metalloproteinase-7 Human Recombinant, Active
  25. GP21939 MMP 8 Human Matrix Metalloproteinase-8 Human Recombinant
  26. GP21940 MMP 8 Human, His Matrix Metalloproteinase-8 Human Recombinant, His Tag
  27. GP21941 MMP 9 Human 基质金属蛋白酶 9 人重组体
  28. GP21946 MMP 9 Rabbit Matrix Metalloproteinase-9 Rabbit Recombinant
  29. GP25563 MMP-2 Human, HEK

    Matrix Metalloproteinase-2 Human Recombinant, HEK
  30. GC69480 MMP-7-IN-1 MMP-7-IN-1 是一种有效的、选择性 MMP-7 抑制剂 (IC50=10 nM)，而对 MMP-1, -2, -3, -8, -9, -13 的 IC50>11 mM。MMP-7 是癌症和纤维化等疾病的潜在靶点。
  31. GP21931 MMP1 (24-207) Human Matrix Metalloproteinase-1 (24-207 a.a) Human Recombinant, HEK
  32. GP21930 MMP1 Human, sf9 Matrix Metalloproteinase-1 Human Recombinant, sf9
  33. GP21947 MMP10 Human Matrix Metallopeptidase 10 Human Recombinant
  34. GC65957 MMP13-IN-2 MMP13-IN-2 是一种有效、选择性和口服活性的 MMP-13 抑制剂。MMP13-IN-2 对 MMP-13 具有优异的效价 (IC50=0.036 nM)，对 MMP-1、3、7、8、9、14 和 TACE 的选择性(大于 1500 倍)。MMP13-IN-2 在体外具有阻止软骨释放胶原蛋白的能力。MMP13-IN-2 具有胶原酶相关疾病研究的潜力。
  35. GC63322 MMP13-IN-3 An inhibitor of MMP-13
  36. GP21950 MMP14 Human Matrix Metalloproteinase-14 Human Recombinant
  37. GP29001 MMP14 Human, His MMP14 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 527 amino acids (21-538a
  38. GP21933 MMP2 Human 基质金属蛋白酶 2 人重组体
  39. GP26167 MMP2 Mouse MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
  40. GC69479 MMP2-IN-1 MMP2-IN-1 是一种中度有效的 MMP2 抑制剂，IC50 为 6.8 µM。MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡 (apoptosis)，在某些癌细胞中表现出显著的抗增殖活性。
  41. GP21948 MMP23B Human Matrix Metallopeptidase 23B Human Recombinant
  42. GP21949 MMP28 Human Matrix Metalloproteinase-28 Human Recombinant
  43. GP21942 MMP9 Human, HEK Matrix Metalloproteinase-9 Human Recombinant, HEK
  44. GP21943 MMP9 Human, Sf9 Matrix Metalloproteinase-9 Human Recombinant, Sf9
  45. GP26168 MMP9 Mouse MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
  46. GC69554 NFF-3 TFA NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3 和 MMP-10 而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA，可在细胞实验中产生荧光，而检测细胞活性。
  47. GC63132 Otaplimastat Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂，以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。
  48. GP21944 ProMatrilysin ProMatrix Metalloproteinase-7 Recombinant
  49. GP21945 ProMMP 9 Human Pro-Matrix Metalloproteinase-9 Human Recombinant
  50. GC46220 SD 2590 (hydrochloride) An MMP inhibitor
  51. GC50353 T 26c disodium salt A selective inhibitor of MMP-13

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