MMP(基质金属蛋白酶)
- Cat.No. 产品名称 Information
-
GC64535
(S,S)-TAPI-1
TAPI
A TACE inhibitor -
GC45978
1,10-Phenanthroline (hydrate)
邻菲罗啉,1,10-Phenanthroline monohydrate
A metal chelator and inhibitor of metalloproteases -
GC46769
Abametapir
55'-二甲基-2,2-联吡啶
A building block and an insecticide - GC71415 Aderamastat Aderamastat(FP-025)是一种口服活性基质金属蛋白酶12(MMP-12)抑制剂。
-
GC63661
Aderbasib
(6S,7S)-7-[(羟基氨基)甲酰基]-6-[(4-苯基-1-哌嗪基)甲酰基]-5-氮杂螺[2.5]辛烷-5-甲酸甲酯,INCB007839; INCB7839
Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性,可用于癌症研究,包括弥漫性大 B 细胞非霍奇金淋巴瘤,HER2+ 乳腺癌,胶质瘤等。 -
GC68656
Andecaliximab
Anti-MMP9 Reference Antibody (andecaliximab)
Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化疗效。Andecaliximab 可用于胃腺癌和特发性肺纤维化 (IPF) 的研究。 -
GC62347
CMC2.24
TRB-N0224
CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂,通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂,IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。 - GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
-
GC68925
cyclo(RLsKDK) TFA
BK-1361 TFA
cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8 抑制剂,IC50 值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。 -
GC63621
Doxycycline
多西环素
Doxycycline(多西环素DOX)是一种四环素衍生物的广谱抗生素,通过干扰细菌核糖体30S亚基A位点上活化的氨基酰基tRNA的结合来抑制蛋白质合成。 -
GC62948
Edaravone D5
MCI-186-d5
Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。 - GC70201 FN-439 TFA FN-439 TFA是一种选择性胶原酶-1抑制剂。
-
GC60860
FSL-1 TFA
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
-
GC39640
GPLGIAGQ TFA
GPLGIAGQ TFA 是一种 MMP2 可切割的多肽,在脂质体和胶束纳米载体中都被用作刺激敏感的连接物,用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。
-
GC48421
GW 280264X
((S)-5-((2R,3S)-3-(N-羟基甲酰胺基)-2-异丁基六氨基)-2-氧代-6-(噻唑-2-基氨基)己基)氨基甲酸苄酯
An ADAM17/TACE and ADAM10 inhibitor - GC72231 Hepcidin-1 (mouse) (TFA) Hepcidin-1 (mouse) (TFA)是一种参与调节铁稳态的内源性肽激素。
-
GC39134
Isofraxidin
异嗪皮啶
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent. -
GC39095
Isoliquiritin apioside
芹糖异甘草苷
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity. - GC72202 Mca-PLAQAV-Dpa-RSSSR-NH2 TFA Mca-PLAQAV-Dpa-RSSSR-NH2 TFA是一种荧光肽,是TNF-α转化酶(TACE)的荧光底物之一;ADAM17、ADAM9和ADAM10。
- GP21929 MMP 1 Human 基质金属蛋白酶-1 人重组体
- GP21928 MMP 1 Human, HEK Matrix Metalloproteinase-1 Human Recombinant, HEK
- GP21932 MMP 13 Human Matrix Metalloproteinase-13 Human Recombinant
- GP21936 MMP 3 Human Matrix Metalloproteinase-3 Human Recombinant
- GP21935 MMP 3 Human, GST Matrix Metalloproteinase-3 Human Recombinant, GST Tag
- GP21934 MMP 3 Human, HEK Matrix Metalloproteinase-3 Human Recombinant, HEK
- GP21938 MMP 7 Human Matrix Metalloproteinase-7 Human Recombinant
- GP21937 MMP 7 Human, Active Matrix Metalloproteinase-7 Human Recombinant, Active
- GP21939 MMP 8 Human Matrix Metalloproteinase-8 Human Recombinant
- GP21940 MMP 8 Human, His Matrix Metalloproteinase-8 Human Recombinant, His Tag
- GP21941 MMP 9 Human 基质金属蛋白酶 9 人重组体
- GP21946 MMP 9 Rabbit Matrix Metalloproteinase-9 Rabbit Recombinant
-
GP25563
MMP-2 Human, HEK
Matrix Metalloproteinase-2 Human Recombinant, HEK
- GC69480 MMP-7-IN-1 MMP-7-IN-1 是一种有效的、选择性 MMP-7 抑制剂 (IC50=10 nM),而对 MMP-1, -2, -3, -8, -9, -13 的 IC50>11 mM。MMP-7 是癌症和纤维化等疾病的潜在靶点。
- GC71251 MMP-7-IN-2 MMP-7-IN-2(化合物16)是MMP7的选择性抑制剂,IC50值为16nM。
- GC71106 MMP-9-IN-6 MMP-9-IN-6(化合物3g)是一种MMP-9抑制剂,IC50值为50 μM,具有良好的抗溃疡作用。
- GP21931 MMP1 (24-207) Human Matrix Metalloproteinase-1 (24-207 a.a) Human Recombinant, HEK
- GP21930 MMP1 Human, sf9 Matrix Metalloproteinase-1 Human Recombinant, sf9
- GP21947 MMP10 Human Matrix Metallopeptidase 10 Human Recombinant
- GC65957 MMP13-IN-2 MMP13-IN-2 是一种有效、选择性和口服活性的 MMP-13 抑制剂。MMP13-IN-2 对 MMP-13 具有优异的效价 (IC50=0.036 nM),对 MMP-1、3、7、8、9、14 和 TACE 的选择性(大于 1500 倍)。MMP13-IN-2 在体外具有阻止软骨释放胶原蛋白的能力。MMP13-IN-2 具有胶原酶相关疾病研究的潜力。
-
GC63322
MMP13-IN-3
MMP13-IN-3
An inhibitor of MMP-13 - GP21950 MMP14 Human Matrix Metalloproteinase-14 Human Recombinant
- GP29001 MMP14 Human, His MMP14 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 527 amino acids (21-538a
- GP21933 MMP2 Human 基质金属蛋白酶 2 人重组体
- GP26167 MMP2 Mouse MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
- GC69479 MMP2-IN-1 MMP2-IN-1 是一种中度有效的 MMP2 抑制剂,IC50 为 6.8 µM。MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡 (apoptosis),在某些癌细胞中表现出显著的抗增殖活性。
- GP21948 MMP23B Human Matrix Metallopeptidase 23B Human Recombinant
- GP21949 MMP28 Human Matrix Metalloproteinase-28 Human Recombinant
- GP21942 MMP9 Human, HEK Matrix Metalloproteinase-9 Human Recombinant, HEK
- GP21943 MMP9 Human, Sf9 Matrix Metalloproteinase-9 Human Recombinant, Sf9
- GP26168 MMP9 Mouse MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a