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MMP(基质金属蛋白酶)

  1. Cat.No. 产品名称 Information
  2. GC64535 (S,S)-TAPI-1

    TAPI

    A TACE inhibitor
  3. GC45978 1,10-Phenanthroline (hydrate)

    邻菲罗啉,1,10-Phenanthroline monohydrate

    A metal chelator and inhibitor of metalloproteases
  4. GC46769 Abametapir

    55'-二甲基-2,2-联吡啶

    A building block and an insecticide
  5. GC71415 Aderamastat Aderamastat(FP-025)是一种口服活性基质金属蛋白酶12(MMP-12)抑制剂。
  6. GC63661 Aderbasib

    (6S,7S)-7-[(羟基氨基)甲酰基]-6-[(4-苯基-1-哌嗪基)甲酰基]-5-氮杂螺[2.5]辛烷-5-甲酸甲酯,INCB007839; INCB7839

    Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性,可用于癌症研究,包括弥漫性大 B 细胞非霍奇金淋巴瘤,HER2+ 乳腺癌,胶质瘤等。
  7. GC68656 Andecaliximab

    Anti-MMP9 Reference Antibody (andecaliximab)

    Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化疗效。Andecaliximab 可用于胃腺癌和特发性肺纤维化 (IPF) 的研究。
  8. GC62347 CMC2.24

    TRB-N0224

    CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂,通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂,IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。
  9. GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
  10. GC68925 cyclo(RLsKDK) TFA

    BK-1361 TFA

    cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8 抑制剂,IC50 值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
  11. GC63621 Doxycycline

    多西环素

    Doxycycline(多西环素DOX)是一种四环素衍生物的广谱抗生素,通过干扰细菌核糖体30S亚基A位点上活化的氨基酰基tRNA的结合来抑制蛋白质合成。
  12. GC62948 Edaravone D5

    MCI-186-d5

    Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂,能够抑制大鼠与 MMP-9 有关的脑出血。
  13. GC70201 FN-439 TFA FN-439 TFA是一种选择性胶原酶-1抑制剂。
  14. GC60860 FSL-1 TFA

    FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

  15. GC39640 GPLGIAGQ TFA

    GPLGIAGQ TFA 是一种 MMP2 可切割的多肽,在脂质体和胶束纳米载体中都被用作刺激敏感的连接物,用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。

  16. GC48421 GW 280264X

    ((S)-5-((2R,3S)-3-(N-羟基甲酰胺基)-2-异丁基六氨基)-2-氧代-6-(噻唑-2-基氨基)己基)氨基甲酸苄酯

    An ADAM17/TACE and ADAM10 inhibitor
  17. GC72231 Hepcidin-1 (mouse) (TFA) Hepcidin-1 (mouse) (TFA)是一种参与调节铁稳态的内源性肽激素。
  18. GC39134 Isofraxidin

    异嗪皮啶

    Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
  19. GC39095 Isoliquiritin apioside

    芹糖异甘草苷

    Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
  20. GC72202 Mca-PLAQAV-Dpa-RSSSR-NH2 TFA Mca-PLAQAV-Dpa-RSSSR-NH2 TFA是一种荧光肽,是TNF-α转化酶(TACE)的荧光底物之一;ADAM17、ADAM9和ADAM10。
  21. GP21929 MMP 1 Human 基质金属蛋白酶-1 人重组体
  22. GP21928 MMP 1 Human, HEK Matrix Metalloproteinase-1 Human Recombinant, HEK
  23. GP21932 MMP 13 Human Matrix Metalloproteinase-13 Human Recombinant
  24. GP21936 MMP 3 Human Matrix Metalloproteinase-3 Human Recombinant
  25. GP21935 MMP 3 Human, GST Matrix Metalloproteinase-3 Human Recombinant, GST Tag
  26. GP21934 MMP 3 Human, HEK Matrix Metalloproteinase-3 Human Recombinant, HEK
  27. GP21938 MMP 7 Human Matrix Metalloproteinase-7 Human Recombinant
  28. GP21937 MMP 7 Human, Active Matrix Metalloproteinase-7 Human Recombinant, Active
  29. GP21939 MMP 8 Human Matrix Metalloproteinase-8 Human Recombinant
  30. GP21940 MMP 8 Human, His Matrix Metalloproteinase-8 Human Recombinant, His Tag
  31. GP21941 MMP 9 Human 基质金属蛋白酶 9 人重组体
  32. GP21946 MMP 9 Rabbit Matrix Metalloproteinase-9 Rabbit Recombinant
  33. GP25563 MMP-2 Human, HEK

    Matrix Metalloproteinase-2 Human Recombinant, HEK

  34. GC69480 MMP-7-IN-1 MMP-7-IN-1 是一种有效的、选择性 MMP-7 抑制剂 (IC50=10 nM),而对 MMP-1, -2, -3, -8, -9, -13 的 IC50>11 mM。MMP-7 是癌症和纤维化等疾病的潜在靶点。
  35. GC71251 MMP-7-IN-2 MMP-7-IN-2(化合物16)是MMP7的选择性抑制剂,IC50值为16nM。
  36. GC71106 MMP-9-IN-6 MMP-9-IN-6(化合物3g)是一种MMP-9抑制剂,IC50值为50 μM,具有良好的抗溃疡作用。
  37. GP21931 MMP1 (24-207) Human Matrix Metalloproteinase-1 (24-207 a.a) Human Recombinant, HEK
  38. GP21930 MMP1 Human, sf9 Matrix Metalloproteinase-1 Human Recombinant, sf9
  39. GP21947 MMP10 Human Matrix Metallopeptidase 10 Human Recombinant
  40. GC65957 MMP13-IN-2 MMP13-IN-2 是一种有效、选择性和口服活性的 MMP-13 抑制剂。MMP13-IN-2 对 MMP-13 具有优异的效价 (IC50=0.036 nM),对 MMP-1、3、7、8、9、14 和 TACE 的选择性(大于 1500 倍)。MMP13-IN-2 在体外具有阻止软骨释放胶原蛋白的能力。MMP13-IN-2 具有胶原酶相关疾病研究的潜力。
  41. GC63322 MMP13-IN-3

    MMP13-IN-3

    An inhibitor of MMP-13
  42. GP21950 MMP14 Human Matrix Metalloproteinase-14 Human Recombinant
  43. GP29001 MMP14 Human, His MMP14 Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 527 amino acids (21-538a
  44. GP21933 MMP2 Human 基质金属蛋白酶 2 人重组体
  45. GP26167 MMP2 Mouse MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
  46. GC69479 MMP2-IN-1 MMP2-IN-1 是一种中度有效的 MMP2 抑制剂,IC50 为 6.8 µM。MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡 (apoptosis),在某些癌细胞中表现出显著的抗增殖活性。
  47. GP21948 MMP23B Human Matrix Metallopeptidase 23B Human Recombinant
  48. GP21949 MMP28 Human Matrix Metalloproteinase-28 Human Recombinant
  49. GP21942 MMP9 Human, HEK Matrix Metalloproteinase-9 Human Recombinant, HEK
  50. GP21943 MMP9 Human, Sf9 Matrix Metalloproteinase-9 Human Recombinant, Sf9
  51. GP26168 MMP9 Mouse MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a

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