Mitochondrial Metabolism(线粒体代谢)
Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.
Products for Mitochondrial Metabolism
- Cat.No. 产品名称 Information
- GC44444 N-Oleoyl Valine A TRPV3 antagonist
- GC47739 NADH (sodium salt hydrate) A reduced form of NAD+
- GC44308 NADP+ (sodium salt hydrate) The oxidized form of NADPH
- GC47747 Napyradiomycin A1 A fungal metabolite with diverse biological activities
- GC40669 Nerol A monoterpene
- GC49511 Nicorandil N-oxide A metabolite of nicorandil
- GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
- GC31646 NIM811 ((Melle-4)cyclosporin) NIM811 ((Melle-4)cyclosporin) ((Melle-4)cyclosporin; SDZ NIM811 ((Melle-4)cyclosporin)) 是一种口服生物可利用的线粒体通透性转换和亲环素双重抑制剂,在体外对丙型肝炎病毒具有有效的活性(丙肝病毒)。
- GC39411 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.
- GC12090 Nonactin A mixture of macrotetralide antibiotics that act as ionophores
- GC52223 Nonadecanoyl-L-carnitine (chloride) A long-chain acylcarnitine
- GC52236 Nonadecanoyl-L-carnitine-d3 (chloride) An internal standard for the quantification of nonadecanoyl-L-carnitine
- GC44464 NSC 109555 An inhibitor of Chk2
- GC44488 Octanoyl Coenzyme A (sodium salt) A medium-chain acyl CoA
- GC49457 Oleoyl-Coenzyme A (sodium salt) 酰基辅酶A硫酯
- GC44506 Oligomycin D An inhibitor of mitochondrial F1FO-ATPase
- GC47868 Palmitoyl-L-carnitine-d3 (chloride) An internal standard for the quantification of palmitoyl-L-carnitine
- GC52306 Pentadecanoyl-L-carnitine (chloride) A CB receptor agonist
- GC40252 Phosphatidic Acids (egg) (ammonium salt) A mixture of phosphatidic acids
- GC18522 Phosphatidylserines (sodium salt) A mixture of phosphatidylserines isolated from soy
- GC48528 Piericidin B A bacterial metabolite with insecticidal and antimicrobial activities
- GC49192 Piracetam-d6 An internal standard for the quantification of piracetam
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GC47980
Propionyl-L-carnitine-d3 (chloride)
An internal standard for the quantification of propionyl-L-carnitine
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GC48030
RC574
An inhibitor of ferroptosis
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GC16775
Rotenone
An inhibitor of mitochondrial complex I
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GC60330
Ru360
Ru360,一种氧桥联的双核钌胺络合物,是一种选择性的线粒体钙摄取(mitochondrialcalciumuptake)抑制剂。Ru360有效抑制Ca2+吸收到线粒体中,IC50为0.184nM。Ru360以高亲和力(Kd为0.34nM)与线粒体结合。Ru360具有抗心律失常和心脏保护作用。
- GC64669 RYL-552 RYL-552 是一种线粒体电子传递链 (ETC) 抑制剂,是恶性疟原虫 NADH 脱氢酶 2 (PfNDH2) 抑制剂。
- GC44860 S1QEL1.1 A suppressor of IQ electron leak
- GC44862 S3QEL-2 A suppressor of mitochondrial electron leak
- GC48547 Sartorypyrone D A fungal metabolite
- GN10091 Schaftoside A flavonoid C-glycoside with diverse biological activities
- GC30459 Senecionine (Senecionan-11,16-dione, 12-hydroxy-) A pyrrolizidine alkaloid with hepatotoxic properties
- GC61274 Senecionine acetate Senecionineacetate(O-Acetylsenecionine)是吡咯烷核生物碱。Senecionineacetate通过使游离巯基失活来抑制线粒体和线粒体区室中Ca2+的螯合。
- GC48077 SHS4121705 A mitochondrial uncoupler
- GC48894 SIH An iron chelator
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GC31491
Speract
Speract是一种调节精子活力的海胆蛋肽,也刺激精子线粒体代谢。
- GC63669 T0467 T0467 以 PINK1 依赖的方式激活线粒体 parkin 易位。T0467 不诱导多巴胺能神经元中 PINK1 的线粒体聚集。T0467 是一种潜在的PINK1-Parkin 信号激活化合物,可用于帕金森病及相关疾病的研究。
- GC39512 Tempo Tempo 是一种经典的一氧化氮自由基,也 是一种线粒体 ROS 的选择性清除剂,可在催化循环中使超氧化物歧化。Tempo 可诱导 DNA 链断裂,并可用作将伯醇氧化为醛的有机催化剂。Tempo 具有诱变和抗氧化作用。
- GC45020 Tetrachlorohydroquinone A metabolite of pentachlorophenol
- GC48924 TFM A piscicide
- GC17228 Thiabendazole A broad-spectrum anthelmintic
- GC64688 THP104c THP104c 是线粒体分裂的抑制剂。
- GC49529 Thymidine-d4 An internal standard for the quantification of thymidine
- GC48192 trans-2-Octenoyl-L-carnitine A synthetic carnitine
- GC63238 Tricarballylic acid Tricarballylic acid (β-Carboxyglutaric acid, Propane-1,2,3-tricarboxylic acid) is an inhibitor of aconitase and therefore interferes with the Krebs cycle.
- GC13726 TRO 19622 A mitochondrial-targeted neuroprotective agent
- GC11865 UK-5099 An inhibitor of the mitochondrial pyruvate carrier
- GC30512 Vatiquinone (EPI-743) A metabolite of α-tocotrienol with antioxidant and ferroptosis inhibitory activity
- GC48398 WST-1 A water-soluble and cell-permeable tetrazolium dye