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N-Oleoyl Glutamine Sale

(Synonyms: N-Oleoyl Gln) 目录号 : GC47789

An endogenous N-acyl amine

N-Oleoyl Glutamine Chemical Structure

Cas No.:247150-73-8

规格 价格 库存 购买数量
1 mg
¥770.00
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5 mg
¥3,272.00
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10 mg
¥6,167.00
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25 mg
¥13,500.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

N-Oleoyl glutamine is an endogenous N-acyl amine.1,2 It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 µM) induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64%.3 It inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with transient receptor potential vanilloid 1 (TRPV1) and red fluorescent protein (RFP).2 N-Oleoyl glutamine (100 mg/kg) reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice.

1.Long, J.Z., Svensson, K.J., Bateman, L.A., et al.The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondriaCell166(2)1-12(2016) 2.Long, J.Z., Roche, A.M., Berdan, C.A., et al.Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociceptionProc. Natl. Acad. Sci. U.S.A.115(29)E6937-E6945(2018) 3.Lin, H., Long, J.Z., Roche, A.M., et al.Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogues that stimulate mitochondrial respirationJ. Med. Chem.61(7)3224-3230(2018)

Chemical Properties

Cas No. 247150-73-8 SDF
别名 N-Oleoyl Gln
Canonical SMILES O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](C(O)=O)CCC(N)=O
分子式 C23H42N2O4 分子量 410.6
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4355 mL 12.1773 mL 24.3546 mL
5 mM 0.4871 mL 2.4355 mL 4.8709 mL
10 mM 0.2435 mL 1.2177 mL 2.4355 mL
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