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P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for  P450

  1. Cat.No. 产品名称 Information
  2. GC44554 Pantoprazole Sulfide A pantoprazole metabolite
  3. GC44492 O-Desmethyl Metoprolol A major active metabolite of metoprolol
  4. GC44451 Norfluoxetine (hydrochloride) An active metabolite of fluoxetine
  5. GC44351 N-Desmethyl Sildenafil (citrate) A major metabolite of sildenafil
  6. GC44350 N-Desmethyl Sildenafil A major metabolite of sildenafil
  7. GC44348 N-desmethyl Bendamustine An active metabolite of bendamustine
  8. GC44345 N-Desethyl Vardenafil A vardenafil metabolite
  9. GC44299 N-Acetyl-4-benzoquinone imine A reactive CYP450 metabolite of acetaminophen
  10. GC44033 Lansoprazole sulfone A metabolite of lansoprazole
  11. GC43879 Hydroxy Ebastine An ebastine metabolite
  12. GC43743 Gemfibrozil 1-O-β-Glucuronide A major metabolite of gemfibrozil
  13. GC43627 Erythromycin lactobionate A macrolide antibiotic and water-soluble form of erythromycin
  14. GC43626 Erythromycin A N-oxide A potential impurity in commercial preparations of erythromycin
  15. GC43621 Epoxy Fluor 7 A sensitive fluorescent substrate for soluble epoxide hydrolase
  16. GC43440 Dibenzylfluorescein A fluorogenic cytochrome P450 substrate
  17. GC43401 Dehydro Nifedipine An active metabolite of nifedipine
  18. GC43400 Dehydro Aripiprazole (hydrochloride) The primary, active metabolite of aripiprazole
  19. GC43278 Clindamycin Sulfoxide An active metabolite of clindamycin
  20. GC43158 CAY10462 A potent, selective 20-HETE synthase inhibitor
  21. GC42888 Azamulin A selective CYP3A inhibitor
  22. GC42887 Axitinib Sulfoxide A major inactive metabolite of axitinib
  23. GC42879 Avanafil metabolite M4 An active metabolite of avanafil
  24. GC42878 Avanafil metabolite M16 A major inactive metabolite of avanafil
  25. GC42626 8-hydroxy Efavirenz A major metabolite of efavirenz
  26. GC42586 6α-hydroxy Paclitaxel A metabolite of paclitaxel
  27. GC42584 6-O-desmethyl Donepezil An active metabolite of donepezil
  28. GC42580 6-hydroxy Chlorzoxazone A metabolite of chlorzoxazone
  29. GC42551 5-hydroxymethyl Tolterodine (formate) An active metabolite of tolterodine and fesoterodine
  30. GC42550 5-hydroxy-6-methoxy (S)-Duloxetine A metabolite of (S)-duloxetine
  31. GC42546 5-hydroxy Diclofenac An active metabolite of diclofenac
  32. GC42405 4-hydroxy Atorvastatin (calcium salt) A metabolite of atorvastatin
  33. GC42083 20-HETE Ethanolamide A putative CYP450 metabolite of AEA
  34. GC41945 16-hydroxy Hexadecanoic Acid CYP450 metabolite of palmitic acid
  35. GC41837 1,3,7-Trimethyluric Acid A metabolite of caffeine
  36. GC41720 (R)-Omeprazole (sodium salt) An inactive isomer of a gastric proton pump inhibitor
  37. GC41694 (3S)-hydroxy Quinidine An active quinidine metabolite
  38. GC41663 (±)7(8)-DiHDPA A major metabolite of DHA
  39. GC41660 (±)4(5)-EpDPA methyl ester Stable precursor of (±)4(5)-EpDPA, a CYP450 metabolite of DHA
  40. GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol A cytochrome P450 metabolite of 2-AG
  41. GC41655 (±)19(20)-EDP Ethanolamide An ω-3 endocannabinoid epoxide and CB receptor agonist
  42. GC41653 (±)16(17)-DiHDPA An epoxygenase metabolite of DHA
  43. GC41652 (±)14(15)-EpEDE A monoepoxide derived from 8,11,14-eicosatrienoic acid
  44. GC41651 (±)14(15)-EET-SI A potent, metabolically stable analog of 14(15)-EpETrE
  45. GC41648 (±)13(14)-DiHDPA A metabolite of DHA
  46. GC41611 Curcumenol A sesquiterpene
  47. GC41480 3'-hydroxy Lidocaine A metabolite of lidocaine
  48. GC41474 20-hydroxy Prostaglandin E2 An intermediate in the metabolism of PGE2
  49. GC41380 N-desmethyl Rosiglitazone A major metabolite of rosiglitazone
  50. GC41373 Methysticin A natural kavalactone
  51. GC41339 Pioglitazone Ketone An active metabolite of pioglitazone

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