P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
Products for P450
- Cat.No. 产品名称 Information
- GC49399 N-Desbutyl Dronedarone (hydrochloride) An active metabolite of dronedarone
- GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline A food-derived carcinogen
- GC49355 Norfluoxetine-d5 (hydrochloride) An internal standard for the quantification of norfluoxetine
- GC49320 7-Ethoxy-4-(trifluoromethyl)coumarin A fluorogenic substrate for CYPs
- GC49291 rac-N-desmethyl Ivabradine-d6 (hydrochloride) An internal standard for the quantification of N-desmethyl ivabradine
- GC49288 Dolutegravir M1 A metabolite of dolutegravir
- GC49281 SPA70 A PXR antagonist
- GC49230 Ferroprotoporphyrin An iron-containing cofactor
- GC49212 trans-carboxy Glimepiride A metabolite of glimepiride
- GC49202 Desmethyl Mirtazapine (hydrochloride) A metabolite of mirtazapine
- GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide
- GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
- GC49185 Mirtazapine N-oxide A metabolite of mirtazapine
- GC49169 3,8’-Biapigenin A biflavonoid with diverse biological activities
- GC49159 2-(1-Piperazinyl)pyrimidine An α2-AR antagonist and active metabolite of azapirones
- GC49146 Colupulone A β-acid with diverse biological activities
- GC49133 N-hydroxy Riluzole A metabolite of riluzole
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GC49118
10-hydroxy Warfarin
A metabolite of (R)-warfarin
- GC49107 Rosuvastatin lactone The lactone form of rosuvastatin
- GC49096 Cobaltic Protoporphyrin IX (chloride) An inducer of HO-1 activity
- GC49055 Tebuconazole-d9 An internal standard for the quantification of tebuconazole
- GC49030 7-Ethoxycoumarin A CYP450 substrate
- GC62491 BMS-986202 BMS-986202 是一种有效的,选择性的,具有口服活性的 Tyk2 抑制剂,可与 Tyk2 JH2 结合,IC50 为 0.19 nM,Ki 为 0.02 nM。BMS-986202 对包括 Jak 家族成员在内的其他激酶具有高度选择性。BMS-986202 还是 CYP2C19 的弱抑制剂,IC50 为 14 μM。BMS-986202 可用于 IL-23 驱动的棘皮症,抗 CD40 诱导的结肠炎和自发性狼疮的研究。
- GC62476 Nampt-IN-5 Nampt-IN-5 是一种有效的烟酰胺磷酸核糖基转移酶 (NAMPT) 抑制剂。Nampt-IN-5 还抑制 CYP3A4 活性。Nampt-IN-5 可抑制 A2780 和 COR-L23 细胞,IC50 值分别为 0.7 nM 和 3.9 nM。
- GC62304 Dapaconazole Dapaconazole 作为一种抗真菌化合物,抑制 sterol 14α-demethylase cytochrome P450 活性的 IC50 值为 1.4 μM。
- GC61814 5,7-Dimethoxyflavone 5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.
- GC61811 Verapamil Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
- GC61722 2,6-Dimethylquinoline 2,6-Dimethylquinoline是一种来自Peucedantupraeruptorum根的天然成分,是CYP1A2的抑制剂,IC50为3.3µM。2,6-Dimethylquinoline也抑制CYP2B6的活性,IC50为480µM。
- GC61574 AS1810722 AS1810722是口服有效的STAT6抑制剂,IC50为1.9nM。AS1810722显示出良好的CYP3A4抑制作用。AS1810722是一种稠合双环嘧啶衍生物,具有用于过敏性疾病,例如哮喘和特应性疾病研究的潜力。
- GC61465 SDZ285428 SDZ285428是一种CYP51抑制剂。SDZ285428抑制Trypanosomacruzi(TC)CYP51,I/E2<1(5min)及I/E2=9(1h)。SDZ285428抑制Trypanosomabrucei(TB)CYP51,I/E2<1(5min)及I/E2=35(1h)。
- GC18252 Diallyl Sulfide An organosulfur compound
- GC48804 N-desmethyl Olanzapine A major metabolite of olanzapine
- GC48493 PCI 45227 An active metabolite of ibrutinib
- GC48461 rac-trans-4-hydroxy Glyburide An active metabolite of glyburide
- GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole
- GC47923 Paraxanthine-d6 An internal standard for the quantification of paraxanthine
- GC47756 N-desmethyl Rosuvastatin (sodium salt hydrate) An active metabolite of rosuvastatin
- GC47367 Fluvastatin (sodium salt hydrate) An HMG-CoA reductase inhibitor
- GC47234 Diosmetin-d3 An internal standard for the quantification of diosmetin
- GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine
- GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine
- GC47118 Colchicoside A glycoside form of 3-demethylcolchicine
- GC47064 CAY10770 An inhibitor of CYP4Z1
- GC47040 Carebastine-d5 An internal standard for the quantification of carebastine
- GC46933 Bitertanol A triazole fungicide
- GC46842 Amiodarone-d4 (hydrochloride) An internal standard for the quantification of amiodarone
- GC46835 Alyssin An isothiocyanate with diverse biological activities
- GC46678 4β-hydroxy Cholesterol-d7 An internal standard for the quantification of 4β-hydroxy cholesterol
- GC46475 19R(20S)-EpDPA A DHA metabolite
- GC46464 17R(18S)-EpETE An EPA metabolite and activator of KCa1.1/BK channels