Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O₂^-), hydrogen peroxide (H₂O₂), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for Reactive Oxygen Species

Cat.No. 产品名称 Information
GC18645 Piperitenone
NSC 667470

A monoterpene
GC71945 Piperkadsin A Piperkadsin A是ROS的强效抑制剂。
GC10282 Piperlongumine
荜茇酰胺; Piplartine
Piperlongumine是从Piper longum L.中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。
GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
GC46019 Pluviatolide
(-)-Pluviatolide
A lignan
GC44670 PPA The product of peroxidase-catalyzed reduction of PPHP
GC44672 PPHP A substrate used to quantitate peroxidase activity
GN10599 Procyanidin B2
原花青素 B2; Proanthocyanidin B2
Procyanidin B2 是一种天然黄酮类物质，具有抗肿瘤，抗氧化等作用。
GC47977 Propiconazole
丙环唑
Propiconazole是一种口服有效的N-取代三唑类丙环唑，具有抗真菌活性。
GC47978 Propiconazole-d3 (nitrate) A neuropeptide with diverse biological activities
GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole
GC47980 Propionyl-L-carnitine-d3 (chloride)
L-Propionylcarnitine-d3 chloride; ST-261-d3

An internal standard for the quantification of propionyl-L-carnitine
GC49120 Prosaptide TX14(A) (trifluoroacetate salt)
Prosaposin-derived 14-mer Peptide TX14(A)
A peptide fragment of prosaposin and GPR37L1 and GPR37 agonist
GN10805 Protopanaxdiol
20 (S)-原人参二醇; 20-Epiprotopanaxadiol; 20(S)-APPD
A sapogenin with anticancer and antibacterial activities
GN10237 Protopine
原阿片碱,Corydinine
An alkaloid with diverse biological activities
GC14847 Psoralidin
补骨脂定
A furanocoumarin with anti-cancer activity
GC40006 Pyranonigrin A
7-hydroxy Pyranonigrin S
A fungal metabolite with antioxidant activity
GC48019 Quercetin (hydrate)
槲皮素二水合物
A flavonoid with diverse biological activities
GC48020 Quercetin-d3 (hydrate) A neuropeptide with diverse biological activities
GN10814 Quercitrin
槲皮苷; Quercetin 3-rhamnoside
A flavonoid glycoside
GC62399 RA375 RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。
GC66363 Randialic acid B Randialic acid B 是一种三萜化合物，是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。
GC48029 RC363 An inhibitor of ferroptosis
GC48030 RC574
An inhibitor of ferroptosis
GC49790 Reuterin
罗氏菌素,3-Hydroxypropionaldehyde; 3-Hydroxypropanal
A bacterial glycerol metabolite with antibacterial activity
GC34758 Reynoutrin
槲皮素-3-D-木糖甙,Quercetin-3-D-xyloside; Reinutrin

A flavonoid glycoside with diverse biological activities
GN10475 Rhein
大黄酸; Rheic Acid; Rhubarb yellow; Monorhein
An anthraquinone derivative
GC37531 Riboflavin Tetrabutyrate
核黄素四丁酸酯；四丁酸核糖黄素酯
Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.
GC67903 RIDR-PI-103 RIDR-PI-103 是一种活性氧 (ROS) 诱导的药物释放前药，具有与泛 PI3K 抑制剂 (PI-103) 连接的自环化部分。Doxorubicin 和 RIDR-PI-103 在 MDA-MB-361 和 MDA-MB-231 细胞中显示出抑制癌细胞增殖的协同作用。
GC39239 Rifamycin S
利福霉素S
Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
GC48401 Risuteganib (trifluoroacetate salt)
ALG-1001
An anti-integrin peptide
GC69831 ROS-ERS inducer 1 ROS-ERS inducer 1 是一种 II 型 ICD (免疫原性细胞死亡) 诱导剂。ROS-ERS inducer 1 是一种源自 4,5-二芳基咪唑的 Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物。ROS-ERS inducer 1 成功诱导内质网应激 (ERS) 伴随活性氧 (ROS) 的产生，并最终导致 HCC 细胞中损伤相关分子模式 (DAMP) 的释放。ROS-ERS inducer 1 显示出比 Cisplatin 高得多的抗癌活性。
GC73225 ROS-generating agent 1 ROS-generating agent 1（化合物2c）共价修饰TrxR的Sec-498残基生成ROS。
GC39100 Rutaevin
吴茱萸苦素
Rutaevin 从 Euodia rutaecarpa 中分离。 Rutaevin 能够抑制 Raw 264.7 巨噬细胞中 LPS 诱导的 NO 的产生。
GN10693 Rutin
芦丁; Rutoside; Quercetin 3-O-rutinoside
芦丁 (Rutoside) 是一种在许多植物中发现的类黄酮，具有广泛的生物活性，包括抗炎、抗糖尿病、抗氧化、神经保护、肾保护、保肝和降低 Aβ 寡聚体活性。
GC44860 S1QEL1.1
S1QEL
A suppressor of I_Q electron leak
GC73031 Salpyran dihydrochloride Salpyran dihydrochloride是一种具有治疗潜力的Cu（II）选择性螯合剂。
GC12517 Sasapyrine
双水杨酸酯; Salicylsalicylic acid; Disalicylic acid
An NSAID and a prodrug form of salicylic acid
GC46219 Satratoxin H A trichothecene mycotoxin
GN10132 Schizandrin B
五味子乙素; γ-Schisandrin; Wuweizisu B
A dibenzocyclooctadiene with diverse biological activities
GC48973 Sekikaic Acid A lichen metabolite with diverse biological activities
GC73188 SFI003 SFI003是一种SRSF3抑制剂，通过SRSF3/DHCR24/ROS轴驱动CRC细胞凋亡，在体外和体内均表现出强大的抗肿瘤作用。
GC62242 Sideroxylin Sideroxylin 是一种从 Callistemon lanceolatus 中分离的 C-甲基化黄酮，对金黄色葡萄球菌具有抗菌活性。Sideroxylin 可抑制卵巢癌细胞增殖并诱导凋亡 (apoptosis)，导致 DNA 断裂，线粒体膜去极化，产生活性氧 (ROS)。
GN10292 Silibinin
水飞蓟宾,Silibinin A; Silymarin I
Silibinin是一种具有口服活性的类黄酮，具有保肝和抗癌作用。
GC70480 Simvastatin acid calcium hydrate Simvastatin acid calcium hydrate是一种强效的HMG-CoA还原酶（HMGCR）抑制剂。
GC30033 Sinapine thiocyanate
芥子碱硫氰酸盐
Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.
GC31511 Sinapinic acid (Sinapic acid)
芥子酸; Sinapic acid
A phenylpropanoid hydroxycinnamic acid with diverse biological activities
GC72573 Sodium 2-oxopropanoate-13C Sodium 2-oxopropanoate-13C是13C标记的2-氧丙酸钠。
GC13616 Sodium ascorbate
维生素C钠; Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt
抗坏血酸钠（Sodium L-ascorbate）是一种电子供体，是一种内源性抗氧化剂。抗坏血酸钠选择性抑制 Cav3.2 通道，IC50 为 6.5 μM.抗坏血酸钠也是一种胶原蛋白沉积增强剂和弹性生成抑制剂。
GC37661 Sodium formononetin-3'-sulfonate
芒柄花黄素-3'-磺酸钠,Sul-F
Sodium formononetin-3'-sulfonate (Sul-F)是formononetin的水溶性衍生物。