Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O₂^-), hydrogen peroxide (H₂O₂), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for Reactive Oxygen Species

Cat.No. 产品名称 Information
GC47477 JKE-1674 A GPX4 inhibitor and active metabolite of ML-210
GC47478 JKE-1716 A GPX4 inhibitor
GC61993 Kaempferol 3-O-β-D-glucuronide
山奈酚葡萄糖醛酸苷,Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
A flavonol glycoside and an active metabolite of kaempferol with diverse biological activities
GC48507 Kaempferol 3-O-galactoside
三叶豆苷,Trifolin
A flavonoid with diverse biological activities
GC49372 Kaempferol 7-neohesperidoside
山柰酚-7-O-新橙皮糖苷
A flavonoid glycoside with antioxidant and anticancer activities
GC11770 Ketone Ester
酮酯; (R,R)-Ketone Ester
A ketone ester with anti-obesity and anticonvulsant activities
GC49436 L-3-n-Butylphthalide
(-)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(-)-3-Butylphthalide, L-NBP
A phthalide with antiplatelet and neuroprotective activities
GC11707 L-Ascorbyl 6-palmitate
抗坏血酸棕榈酸酯; L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid
A lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities
GC47549 L-Carnosine-d4
β-Alanyl-L-histidine-d4
An internal standard for the quantification of L-carnosine
GC52283 L-Cysteine-15N-d3
L-Cys-15N-d3, L-(+)-Cysteine-15N-d3, (R)-Cysteine-15N-d3
An internal standard for the quantification of L-cysteine
GC12203 L-Glutathione Reduced
还原型谷胱甘肽; GSH; γ-L-Glutamyl-L-cysteinyl-glycine

Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases
GC49560 L6H21 An inhibitor of the MD-2 and TLR4 interaction
GC15550 Lacidipine
拉西地平
An L-type calcium channel blocker
GC18190 Lecanoric Acid
紅粉苔酸
An antioxidant
GC90655 Lentztrehalose B
一种具有多种生物活性的双糖微生物代谢产物。
GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
GC47556 Leukotriene B4-d4
LTB4-d4; 5(S),12(R)-DiHETE-d4
An internal standard for the quantification of leukotriene B₄
GC49597 Leukotriene B4-d5
LTB4-d5
An internal standard for the quantification of LTB₄
GC36443 Levomefolic acid
5-甲基四氢叶酸; 5-MTHF
Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
GC71918 Linocinnamarin Linocinnamarin是一种可以从Fragaria ananassa Duch中分离出来的天然产物。
GN10423 Lipoic acid
硫辛酸
硫辛酸 ((R)-(+)-α-硫辛酸) 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。
GN10582 Liquiritin
甘草苷
A flavonoid with diverse biological activities
GC18789 Lobaric Acid A lichen metabolite with diverse biological activities
GN10569 Lobetyolin
党参炔苷
Lobetyolin是一个由Lobetyol与葡萄糖吡喃糖基取代衍生而成的化合物。
GC49177 Loliolide
地芰普内酯
A monoterpene lactone with diverse biological activities
GC36492 Luciferase
荧光素酶
Luciferase，来自Vibrio fischeri，可用于评估生物发光细菌的光发射和氧消耗动力学。
GC63049 Luciferase-IN-1 Luciferase-IN-1 是一种荧光素酶抑制剂。
GC47582 Lupulone
蛇床酮
A beta-acid
GC61015 Luteolin 5-O-glucoside
木犀草素-5-O-葡萄糖苷
Luteolin5-O-glucoside来自Cirsiummaackii，具有抗炎活性。Luteolin5-O-glucoside抑制LPS诱导的NO生成和t-BHP诱导的ROS生成。Luteolin5-O-glucoside作用于巨噬细胞，还抑制iNOS和COX-2表达。
GN10448 Lycopene
番茄红素
番茄红素（Lycopene）是一种脂溶性类胡萝卜素分子，在红色水果和蔬菜中含量很高，具有强大的抗氧化作用。
GC46031 Malabaricone B
NSC 287967, NSC 630196
A diarylnonanoid with diverse biological activities
GC46028 Malabaricone C
马拉巴酮C
A diarylnonanoid with diverse biological activities
GC40979 Maresin 1
7(R)MaR1, 7(R)Maresin 1

A specialized pro-resolving mediator
GC49486 Meglutol-d3
氘代3-羟基-3-甲基(D3)
An internal standard for the quantification of meglutol
GC30500 Melittoside
蜜力特苷；蜜利特苷
An iridoid glycoside
GC19759 Mesotrione
硝磺草酮
甲基磺草酮是一种除草剂，属于苯甲酰环己二酮家族。
GC48889 Methazolamide-d6
L584601-d6
An internal standard for the quantification of methazolamide
GC30046 Methoxy-PMS (1-Methoxy PMS)
1-甲氧基-5-甲基酚嗪硫酸甲酯盐,1-Methoxy PMS; 1-Methoxyphenazine methosulfate
Methoxy-PMS (1-Methoxy PMS)是一种合成电子传递体，广泛用于脱氢酶活性检测等生化分析。其作为氧化还原介体，促进NAD(P)H与四唑盐之间的电子转移以生成可检测的甲臜产物。Methoxy-PMS（C₁₄H₁₃N₂O₄S）是吩嗪硫酸甲酯（PMS）的甲氧基修饰衍生物，其吩嗪环上的甲氧基显著提升了稳定性和溶解度，增强了光稳定性及水溶性，使其适用于长时间酶反应、高通量筛选以及体外实验中的高效氧化还原循环。
GC47659 Methyl 3,4-Dihydroxyphenylacetate
3,4-二羟基苯乙酸甲酯
A polyphenol with antioxidant and antiviral activities
GC32170 Methyl gallate (Gallincin)
没食子酸甲酯,Gallincin; NSC 363001
A phenol with diverse biological activities
GC91887 Methyl Salicylate-d4
Methyl 2-hydroxybenzoate-d₄
Methyl Salicylate-d4用于GC-或LC-MS定量水杨酸甲酯的内部标准。
GC31794 Methyl vanillate
香草酸甲酯

Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
GC45513 MGR1 A ROS-generating probe
GC44190 MGR2 A negative control for MGR1
GC49521 MHY553
NSC 33005
An agonist of PPARα
GC44191 MHY908 A PPARα and PPARγ dual agonist
GC62564 Mito-LND
Mito-Lonidamine
Mito-LND (Mito-Lonidamine) 是一种具有口服活性的且靶向线粒体的氧化磷酸化 (oxidative phosphorylation (OXPHOS)) 抑制剂。Mito-LND 抑制线粒体生物能，刺激活性氧 (reactive oxygen species) 的形成，并诱导肺癌细胞自噬细胞死亡。
GC44199 MitoB
MitoBoronic Acid
A probe to detect H₂O₂ in mitochondria
GC47683 MitoB-d15 A neuropeptide with diverse biological activities
GC44201 MitoP
MitoPhenol
The end product of a mitochondrial matrix H₂O₂ probe reaction