Reactive Oxygen Species(活性氧)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Products for Reactive Oxygen Species
- Cat.No. 产品名称 Information
- GC44201 MitoP The end product of a mitochondrial matrix H2O2 probe reaction
- GC44204 MitoPQ A mitochondria-targeted redox cycler
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GC44205
Mitoquinol
A mitochondria-targeted antioxidant
- GC49222 Mitoquinol-d15 An internal standard for the quantification of mitoquinol
- GC30416 Mitoquinone (MitoQ) 丝裂霉素(MitoQ)是一种泛醌衍生的抗氧化剂
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GC31292
Mitoquinone mesylate (Mitoquinone methanesulfonate)
甲磺酸对苯二酚(Mitoquinone mesylate (Mitoquinone methanesulfonate)甲磺酸对醌)是广泛使用的针对线粒体的抗氧化剂之一。
-
GC68230
MitoSOX Red
MitoSOX Red是一种靶向线粒体的活细胞荧光探针,最大激发光/发射光为510/580 nm。
- GC69487 Moracin C Moracin C,一种天然产物,是一种抗炎剂。Moracin C 抑制 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO) 从细胞中释放。
- GC62406 Moracin O Moracin O 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin O 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin O 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin O 具有神经保护和抗炎作用。
- GC38978 Moslosooflavone Moslosooflavoneone 是从雪莲中分离出来的类黄酮。 Moslofoflavone 具有抗缺氧和抗炎活性。
- GC40298 N-acetyl-5-Aminosalicylic Acid A metabolite of 5-ASA and sulfasalazine
- GC39756 N-Acetyl-D-cysteine N-Acetyl-D-cysteine 具有抗氧化活性,通过与巯基反应清除 ROS,但不能进入谷胱甘肽代谢途径。
- GC44301 N-acetyl-L-Cysteine amide N-acetyl-L-Cysteine amide (NACA) is a novel antioxidant, the amide form of N-acetylcysteine (NAC).
- GC69530 N-Acetyldopamine dimer-2 N-Acetyldopamine dimer-2 (compound 2) 是具有抗氧化和抗炎活性的 N-acetyldopamine 二聚体可以从蝉皮的黄色粉末中分离出来。N-Acetyldopamine dimer-2 抑制氧化低密度脂蛋白 (LDL) 氧化、ROS 生成、NO 生成和 NF-κB 活性。
- GC52073 N-formyl-2-Aminophenol A bacterial secondary metabolite with antioxidant activity
- GC52007 N-hydroxylamine Dapsone An active metabolite of dapsone
- GN10276 Naringenin A citrus-derived flavonoid
- GN10550 Neosperidin dihydrochalcone A semisynthetic glycoside chalcone and artificial sweetener
- GC40669 Nerol A monoterpene
- GC16889 Nisoldipine A calcium channel inhibitor
- GC62196 Nisoldipine-d7 Nisoldipine-d7 是 Nisoldipine 的氘代物。Nisoldipine(BAY-k 5552)是高效特异的 L 型 Cav1.2 通道阻断剂,IC50 为 10 nM。
- GC11660 Nitisinone An HPPD inhibitor
- GN10325 Nobiletin A flavonoid with diverse biological activities
- GC19765 Norbergenin Norbergenin 是 bergenin 的 O-去甲基衍生物,具有中等的抗氧化活性(在 DPPH 自由基清除中 IC50 为 13 μM;在超氧阴离子清除中为 32 μM)。
- GC41152 Norgestrel A synthetic progestin
- GC13345 NXY-059 A free radical spin trap
- GC18673 OBA-09 A neuroprotective agent
- GC33444 Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) An active metabolite of curcumin with diverse biological activities
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GC34694
Octyl gallate
Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.
- GC40921 Orsellinic Acid A fungal metabolite with antioxidant and neuroprotective activities
- GC38973 Osmundacetone Osmundacetone 是从 Osmundae Rhizoma 中分离出的一种天然产物。
- GC48703 Palmarumycin C3 A fungal metabolite
- GC49422 PAR2 (1-6) amide (human) (trifluoroacetate salt) A peptide agonist of PAR2
- GC44589 Pelargonidin (chloride) An anthocyanidin with diverse biological activities
- GC47932 Pelargonidin 3-O-glucoside (chloride) An anthocyanin with transporter inhibitory and antioxidant properties
- GC44594 Pentafluorobenzenesulfonyl fluorescein A selective, fluorescent probe for H2O2 detection
- GC45777 Peonidin 3-O-glucoside (chloride) An anthocyanin with diverse biological activities
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GC44602
Peroxynitrite
体内NO与超氧化物反应生成过氧亚硝酸盐。
- GC49015 Phenethyl isothiocyanate An isothiocyanate with anticancer activity
- GC30080 Phillygenin (Phillygenol) A lignan with diverse biological activities
- GC47955 Phloroglucinol A phenol with diverse biological activities
- GN10778 Picroside II A flavonoid with diverse biological activities
- GN10120 Pinocembrin A flavonoid with diverse biological activities
- GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities
- GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
- GC46019 Pluviatolide A lignan
- GC44670 PPA The product of peroxidase-catalyzed reduction of PPHP
- GC44672 PPHP A substrate used to quantitate peroxidase activity
- GN10599 Procyanidin B2 A phenol with diverse biological activities
- GC47977 Propiconazole A broad-spectrum triazole fungicide