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Sodium formononetin-3'-sulfonate Sale

(Synonyms: 芒柄花黄素-3'-磺酸钠,Sul-F) 目录号 : GC37661

Sodium formononetin-3'-sulfonate (Sul-F)是formononetin的水溶性衍生物。

Sodium formononetin-3'-sulfonate Chemical Structure

Cas No.:949021-68-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥2,533.00
现货
5mg
¥2,302.00
现货
10mg
¥4,144.00
现货
50mg 待询 待询
100mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. IC50 value:Target: Research results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defense enzymes degraded lipid peroxidn. products and improved energy metab. of cardiac mitochondrial, thus attenuating cardiocyte apoptosis. Other reaearch results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.

[1]. Zhang, Shumin; Tang, Xuexi; Tian, Jingwei et al. Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats. Basic & Clinical Pharmacology & Toxicology (2011), 108(6), 390-395. [2]. Wang, Qiuya; Meng, Qinghua; Zhang, Zunting et al. Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin. Yaoxue Xuebao (2009), 44(4), 386-389. [3]. Cardioprotective Effect of Sulfonated Formononetin on Acute Myocardial Infarction in Rats.

Chemical Properties

Cas No. 949021-68-5 SDF
别名 芒柄花黄素-3'-磺酸钠,Sul-F
Canonical SMILES [O-]S(C1=C(OC)C=CC(C2=COC3=CC(O)=CC=C3C2=O)=C1)(=O)=O.[Na+]
分子式 C16H11NaO7S 分子量 370.31
溶解度 Water: 25 mg/mL (67.51 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7004 mL 13.5022 mL 27.0044 mL
5 mM 0.5401 mL 2.7004 mL 5.4009 mL
10 mM 0.27 mL 1.3502 mL 2.7004 mL
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Research Update

[Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin]

Yao Xue Xue Bao 2009 Apr;44(4):386-9.PMID:19545056doi

A water-soluble compound, Sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of Sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of Sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that Sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.