IκB/IKK
IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.
- Cat.No. 产品名称 Information
-
GC66334
(Rac)-PF-184 hydrate
(Rac)-PF-184 hydrate 是一种有效的 inhibitory factor-κB kinase 2 (IKK-2) 抑制剂,IC50 值为 37 nM。(Rac)-PF-184 hydrate 具有抗炎作用。
-
GC17416
ACHP
An inhibitor of IKKβ and IKKα
-
GC31319
Amlexanox (AA673)
An anti-
inflammatory and anti- allergic compound -
GN10718
Andrographolide
An inhibitor of NF-κB signaling
-
GC10135
AZD3264
An inhibitor of IKK2
-
GC10345
Bay 11-7085
An irreversible inhibitor of IκBα phosphorylation
-
GC13035
Bay 11-7821
A selective and irreversible NF-κB inhibitor
-
GC35474
Bay 65-1942 free base
Bay 65-1942 free base 是一种 ATP 竞争性的选择性 IKKβ 抑制剂。
-
GC16303
Bay 65-1942 HCl salt
Bay 65-1942 HCl salt 是一种 ATP 竞争性和选择性 IKKβ;抑制剂。
-
GC35475
Bay 65-1942 R form
Bay 65-1942 R form 是 Bay 65-1942 的活性较低的 R 型异构体。Bay 65-1942 是一种 ATP 竞争性的选择性 IKKβ 抑制剂。
-
GC60624
BAY-985
A dual inhibitor of TBK1 and IKKε
-
GC18200
BI-605906
An IKKβ inhibitor
-
GC32028
BMS-066
BMS-066是IKKβ/Tyk2的抑制剂,其IC50值分别为9nM,72nM。
-
GC13926
BMS-345541(free base)
BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541(游离碱)结合在 IKK 的变构位点。
-
GC12399
BMS345541 hydrochloride
A selective inhibitor of IKKα and IKKβ
-
GC11573
BX795
A multi-kinase inhibitor
-
GC15083
Celastrol
A triterpenoid antioxidant
-
GC35674
Chicanine
Chicanine 是五味子中的木酚素类化合物,可抑制 LPS 诱导的 p38 MAPK,ERK 1/2 和 IκB-α 的磷酸化水平,具有抗炎活性。
-
GC11170
Choline Fenofibrate
非诺贝特胆碱 (ABT-335) 是一种非诺贝酸的胆碱盐,可在胃肠道中释放游离的非诺贝酸。
-
GC17873
CID-2858522
A selective inhibitor of NF-κB activation
-
GC16044
Emodin
Natural CK2 inhibitor and ER agonist
-
GC33816
Ertiprotafib (PTP 112)
Ertiprotafib (PTP 112) 是 PTP1B,IkB 激酶 β 的抑制剂; (IKK-β) 和双 PPARα;和 PPARβ;激动剂,IC50 为 1.6 μ;M 代表 PTP1B,400 nM 代表 IKK-β;EC50 约为 1 μ;M 代表 PPARα;/PPAR`;
-
GC43786
GS-143
An inhibitor of IκBα ubiquitylation
-
GC65013
GSK8612
A TBK1 inhibitor
-
GC62161
HOIPIN-1
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM for inhibiting the in vitro linear ubiquitination activity of the petit-LUBAC.
-
GN10664
Honokiol
A natural lignan with diverse physiological effects
-
GC63007
HPN-01
HPN-01 是一种有效选择性的 IKK 抑制剂,对 IKK-α、IKK-β 和 IKK-ε 的 pIC50 6.4、7.0 和 <4.8。HPN-01 比 50 多种其他激酶显示出大于50倍的选择性,包括 ALK5、CDK-2、EGFR、ErbB2、GSK3β、PLK1、Src 和 VEGFR-2。
-
GC12370
IKK-16 (hydrochloride)
A potent inhibitor of IKKs
-
GC12180
IKK-16 (IKK Inhibitor VII)
IKK-16 (IKK Inhibitor VII) 是一种选择性 IκB 激酶 (IKK) 抑制剂,作用于 IKK2、IKK 复合物和 IKK1,IC50 分别为 40 nM、70 nM 和 200 nM。
-
GC11508
IKK-2 inhibitor VIII
IKK-2 inhibitor VIII (IKK-2 Inhibitor VIII) 是一种高效和选择性的 IKK-β;抑制剂,IC50 为 8.5 nM。
-
GC10592
IKK-3 Inhibitor
A multi-kinase inhibitor
-
GC13278
IKKε-IN-1
potent IKKε inhibitor
-
GC17830
IMD 0354
An IKKβ (IKK2) inhibitor
-
GC33306
IMD-0560
IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines.
-
GC34907
INH14
INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.
-
GN10370
Luteolin
A common dietary phenolic flavone
-
GC10093
LY2409881
A selective IKK2 inhibitor
-
GC61021
Malachite green oxalate
Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity.
-
GC15942
ML 120B dihydrochloride
IKK2-selective inhibitor
-
GC14989
MLN120B
An IKKβ inhibitor
-
GC66019
MLN120B dihydrochloride
An IKKβ inhibitor
-
GC50093
MRT 68601 hydrochloride
Potent TBK inhibitor
-
GC17136
MRT67307
A kinase inhibitor
-
GC13184
PF 184
PF 184 是一种有效的抑制因子-κB 激酶 2 (IKK-2) 抑制剂,IC50 为 37 nM。
-
GC67890
PHA 408
PHA 408 (PHA-408) 是一种有效的、选择性的、具有口服活性的 IκB kinase-2 (IKK-2) 抑制剂。PHA 408 是一种抗脂多糖 (LPS) 和香烟烟雾 (CS) 介导的肺炎症的强效抗炎药。
-
GN10503
Piceatannol
Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol .
-
GC12609
PS 1145 dihydrochloride
An IKKβ inhibitor
-
GC17603
PS-1145
An IKKβ inhibitor
-
GC11751
QNZ (EVP4593)
An inhibitor of NF-κB activation
-
GC14553
Resveratrol
白藜芦醇(转-白藜芦醇;SRT501)是一种植物抗菌素,具有强大的还原剂作用