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Home >> Signaling Pathways >> Immunology/Inflammation >> IκB/IKK

IκB/IKK

IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.

  1. Cat.No. 产品名称 Information
  2. GC66334 (Rac)-PF-184 hydrate
  3. GC17416 ACHP An inhibitor of IKKβ and IKKα
  4. GC31319 Amlexanox (AA673)

    An anti-inflammatory and anti-allergic compound
  5. GN10718 Andrographolide An inhibitor of NF-κB signaling
  6. GC10135 AZD3264 An inhibitor of IKK2
  7. GC10345 Bay 11-7085 An irreversible inhibitor of IκBα phosphorylation
  8. GC13035 Bay 11-7821 A selective and irreversible NF-κB inhibitor
  9. GC35474 Bay 65-1942 free base
  10. GC16303 Bay 65-1942 HCl salt Bay 65-1942 HCl salt 是一种 ATP 竞争性和选择性 IKKβ；抑制剂。
  11. GC35475 Bay 65-1942 R form
  12. GC60624 BAY-985 A dual inhibitor of TBK1 and IKKε
  13. GC18200 BI-605906 An IKKβ inhibitor
  14. GC32028 BMS-066
  15. GC13926 BMS-345541(free base) BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
  16. GC12399 BMS345541 hydrochloride A selective inhibitor of IKKα and IKKβ
  17. GC11573 BX795 A multi-kinase inhibitor
  18. GC15083 Celastrol A triterpenoid antioxidant
  19. GC35674 Chicanine
  20. GC11170 Choline Fenofibrate 非诺贝特胆碱 (ABT-335) 是一种非诺贝酸的胆碱盐，可在胃肠道中释放游离的非诺贝酸。
  21. GC17873 CID-2858522 A selective inhibitor of NF-κB activation
  22. GC16044 Emodin Natural CK2 inhibitor and ER agonist
  23. GC33816 Ertiprotafib (PTP 112)
  24. GC43786 GS-143 An inhibitor of IκBα ubiquitylation
  25. GC65013 GSK8612 A TBK1 inhibitor
  26. GC62161 HOIPIN-1 HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM for inhibiting the in vitro linear ubiquitination activity of the petit-LUBAC.
  27. GN10664 Honokiol A natural lignan with diverse physiological effects
  28. GC63007 HPN-01
  29. GC12370 IKK-16 (hydrochloride) A potent inhibitor of IKKs
  30. GC12180 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) 是一种选择性 IκB 激酶 (IKK) 抑制剂，作用于 IKK2、IKK 复合物和 IKK1，IC50 分别为 40 nM、70 nM 和 200 nM。
  31. GC11508 IKK-2 inhibitor VIII IKK-2 inhibitor VIII (IKK-2 Inhibitor VIII) 是一种高效和选择性的 IKK-β；抑制剂，IC50 为 8.5 nM。
  32. GC10592 IKK-3 Inhibitor A multi-kinase inhibitor
  33. GC13278 IKKε-IN-1 potent IKKε inhibitor
  34. GC17830 IMD 0354 An IKKβ (IKK2) inhibitor
  35. GC33306 IMD-0560 IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines.
  36. GC34907 INH14 INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.
  37. GN10370 Luteolin A common dietary phenolic flavone
  38. GC10093 LY2409881 A selective IKK2 inhibitor
  39. GC61021 Malachite green oxalate Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity.
  40. GC15942 ML 120B dihydrochloride IKK2-selective inhibitor
  41. GC14989 MLN120B An IKKβ inhibitor
  42. GC66019 MLN120B dihydrochloride An IKKβ inhibitor
  43. GC50093 MRT 68601 hydrochloride Potent TBK inhibitor
  44. GC17136 MRT67307 A kinase inhibitor
  45. GC13184 PF 184 PF 184 是一种有效的抑制因子-κB 激酶 2 (IKK-2) 抑制剂，IC50 为 37 nM。
  46. GC67890 PHA 408
  47. GN10503 Piceatannol

    Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol .
  48. GC12609 PS 1145 dihydrochloride An IKKβ inhibitor
  49. GC17603 PS-1145 An IKKβ inhibitor
  50. GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation
  51. GC14553 Resveratrol A polyphenol with diverse biological activities

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