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AZD3264 Sale

目录号 : GC10135

An inhibitor of IKK2

AZD3264 Chemical Structure

Cas No.:1609281-86-8

规格 价格 库存 购买数量
5mg
¥956.00
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25mg
¥3,182.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Target: IKK2

IC50: N/A

AZD3264 is a novel and small molecule IKK2 inhibitor.

IKK2 serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity induces the activation of a transcription factor NF-κB. Activated IKK2 phosphorylates IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded by the ubiquitination pathway, freeing NF-κB, and allowing its entry into the cell nucleus where it activates target genes involved in inflammation and other immune responses. Suppression of IKK2 has been identified as a potential therapeutic option to treat cancer and inflammatory diseases, including asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [1].

In vitro: AZD3264, by inhibiting IKK2, was currently in preclinical development for the potential treatment of inflammatory diseases such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [2].

In vivo: N/A

References:
1.  Llona-Minguez S, Baiget J, Mackay SP. Small-molecule inhibitors of IkappaB kinase (IKK) and IKK-related kinases. Pharm Pat Anal. 2013;2(4):481-98.
2.  Murugan A, et al. Org. Process Res. Dev. 2014, 18, 646-651.

Chemical Properties

Cas No. 1609281-86-8 SDF
化学名 (S)-5-(4-(3,5-dimethylisoxazol-4-yl)-2-(pyrrolidin-3-yloxy)phenyl)-2-ureidothiophene-3-carboxamide
Canonical SMILES CC1=NOC(C)=C1C2=CC(O[C@H]3CCNC3)=C(C4=CC(C(N)=O)=C(NC(N)=O)S4)C=C2
分子式 C21H23N5O4S 分子量 441.5
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.265 mL 11.325 mL 22.6501 mL
5 mM 0.453 mL 2.265 mL 4.53 mL
10 mM 0.2265 mL 1.1325 mL 2.265 mL
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