IκB/IKK
IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.
Products for IκB/IKK
- Cat.No. 产品名称 Information
- GC12372 SC-514 Selective inhibitor of IKK2
- GC10933 Sodium 4-Aminosalicylate 4-氨基水杨酸钠(4-氨基水杨酸钠盐二水合物)是目前用于耐多药结核病的抗分枝杆菌药物之一。
- GC12013 Sodium salicylate 水杨酸钠(水杨酸钠盐)抑制环加氧酶 2(COX-2)活性,与转录因子(NF-κB)激活无关。
- GN10737 Tanshinone IIA A natural product with anti-inflammatory and anti-cancer activity
- GC69998 TBK1-IN-1 TBK1-IN-1 是一种有效的选择性 TANK 结合激酶 1 (TBK1) 抑制剂,IC50 值为 22.4 nM。TBK1-IN-1 抑制 TBK1 下游靶基因 cxcl10 和 ifnβ 的表达。TBK1-IN-1 具有抗癌活性。
- GC37747 TBK1/IKKε-IN-1 TBK1/IKKε-IN-1 是一种双重 TBK1 和 IKKε 抑制剂,IC50s 值 <100 nM。详细信息请参考专利文献 US20160376283 A1 中 Example 60 中的化合物 274。
- GC63212 TBK1/IKKε-IN-4 TBK1/IKKε-IN-4 是一种 6-氨基吡唑并嘧啶衍生物,也是一种有效的,选择性的 TBK1 和 IKKε 抑制剂,IC50 值分别为 13 nM 和 59 nM。TBK1/IKKε-IN-4 对其他蛋白质激酶(包括 PDK1,PI3K 家族成员和 mTOR)的活性降低了 100-1000 倍。
- GC37748 TBK1/IKKε-IN-5 TBK1/IKKε-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.
- GC17621 TPCA-1 A selective inhibitor of IKK2
- GC16658 Vinpocetine An inhibitor of PDE1
- GN10269 Wedelolactone A natural NF-κB inhibitor
- GC13384 WS6 A promoter of β cell proliferation