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CD Antigens(CD抗原)

Cell surface antigens of leukocytes are called CD antigens, and important for immune reactions of organisms. As lymphocytes mature, they express different protein receptors on the cell surface, which can aid in determining the type and maturation stage of the cells being examined. These proteins or antigen markers are called Clusters of Differentiation

The term CD means a cluster of differentiation OR a cluster of determinants which indicates the lineage or maturational stage of lymphocytes. During the course of development from precursor cells into functionally mature forms, lymphocytes display a complex pattern of surface antigens, some of which are acquired at certain stages while others are lost.

These surface antigens were identified initially by monoclonal antibodies and the designations of the antibodies were used often as synonyms for the cell surface proteins they detected, giving rise to a plethora of different names. CD antigens are present on some subpopulations and functional types of leukocytes. CD antigens participate in immune reaction as receptors for cell communication (e.g. adherence molecules, antigen recognizing receptors).

CD antigen nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. Numbers are assigned arbitrarily. A small letter w before the number designation stands for "workshop". It indicates that the CD designation is tentative.

CD antigens are found on practically all known cell types. In some cases CD antigens are expressed only at certain stages of development or under certain conditions, for example after cell activation or in certain disease conditions. In Hematology the morphological criteria is for the description of specific developmental stages of lymphocytes unlike in CD antigens which the use of monoclonal antibodies allows the objective and precise analysis and standardized typing of mature and immature normal and malignant cells of all hematopoietic cell lineages. The use antibodies also helps to delineate the biologic traits that distinguish normal immune and hematopoietic cells from their malignant counterparts, which is utmost important in the understanding of hematological malignancies.

The expression of CD antigens is influenced by cytokines, such as binding of ligands to CD antigens which has shown to modulate the expression of cytokines. CD antigens have been shown to be identical with receptors of cytokines such as CD25 (TAC antigen).

CD antigens appear to carry out cytokine receptor-like functions such as CD27, CD30 and CD40. CD antigens are involved in modulating the biological activities of cytokines such as CD4, CD28 and CD40. CD antigens exist also in soluble forms for example CD14, CD21, CD23, CD27, CD100 and CD137.

The CD Antigen’s designation isn’t related to the biological function, thus CD antigens include receptors, glycans, adhesion molecules, membrane-bound enzymes, etc.

The most commonly know CD antigens are CD4 and CD8 which are markers for T-helper and T-suppressor cells, respectively. CD4 binds to relatively invariant sites on class II major histocompatibility complex molecules outside the peptide-binding groove, which interacts with the T-cell receptor. CD4 is also the central docking receptor for human immunodeficiency virus. CD8 binds to relatively invariant sites on class I major histocompatibility complex molecules outside the peptide-binding groove. CD8 is also expressed on a subset of dendritic cells. Other more important CD antigens include the leukocytes integrins (CD11/CD18) and the hematopoietic stem cell marker CD34.

CD69 is homologous to members of a supergene family of type II integral membrane proteins having C-type lectin domains. Although the precise functions of the CD-69 antigen is not known, evidence suggests that these proteins transmit mitogenic signals across the plasma membrane and are up- regulated in response to lymphocyte activation

In the last decade the wide palette of monoclonal antibodies has been prepared which recognise of CD antigens on human cells. Much less monoclonal antibodies are available specific for typing of domestic animal cells. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI).

Products for  CD Antigens

  1. Cat.No. 产品名称 Information
  2. GP23044 CD300C Human, Sf9 CD300C Human Recombinant, Sf9
  3. GP23043 CD300C Human CD300C Human Recombinant
  4. GP23042 CD276 Human CD276 Human Recombinant
  5. GP23041 CD274 Mouse CD274 Mouse Recombinant
  6. GP23040 CD274 Human, Sf9 CD274 Human Recombinant, Sf9
  7. GP23039 CD274 Human CD274 Human Recombinant
  8. GP23038 CD74 Human, Sf9 CD74 Human Recombinant, Sf9
  9. GP23037 CD74 Human CD74 Human Recombinant
  10. GP23036 CD27 Human, sf9 CD27 Human Recombinant, sf9
  11. GP23035 CD27 Human CD27 Human Recombinant
  12. GP23034 CD247 Human, Sf9 CD247 Human Recombinant, Sf9
  13. GP23033 CD247 Human CD247 Human Recombinant
  14. GP23032 CD244 Human, Sf9 CD244 Human Recombinant, Sf9
  15. GP23031 CD244 Human CD244 Human Recombinant
  16. GP23030 CD226 Human, Sf9 CD226 Human Recombinant, Sf9
  17. GP23029 CD226 Human CD226 Human Recombinant
  18. GP23028 CD164L2 Human CD164 Sialomucin-Like 2 Human Recombinant
  19. GP23027 CD164 Human CD164 Human Recombinant
  20. GP23026 CD47 Human, IgG-His CD47 Human Recombinant, IgG-His Tag
  21. GP23025 CD47 Human CD47 Human Recombinant
  22. GP23024 CD44 Human CD44 Human Recombinant
  23. GP23023 CD28 Human CD28 Human Recombinant
  24. GP23022 CD23 Human, Sf9 CD23 Human Recombinant, Sf9
  25. GP23021 sCD23 Human Soluble CD23 Human Recombinant
  26. GP23020 CD22 Human CD22 Human Recombinant
  27. GP23019 CD19 Human CD19 Human Recombinant
  28. GP23018 CD9 Human CD9 Human Recombinant
  29. GP23017 CD80 Mouse CD80 Mouse Recombinant
  30. GP23016 CD8B Human, Sf9 CD8B Human Recombinant, Sf9
  31. GP23015 CD8B Human CD8B Human Recombinant
  32. GP23014 CD7 Human, Sf9 CD7 Human Recombinant, Sf9
  33. GP23013 CD7 Human CD7 Human Recombinant
  34. GP23012 CD5L Mouse CD5 Molecule-Like Mouse Recombinant
  35. GP23011 CD5L Human, HEK CD5 Molecule-Like Human Recombinant, HEK
  36. GP23010 CD5L Human CD5 Molecule-Like Human Recombinant
  37. GP23009 CD5 Human, Sf9 CD5 Human Recombinant, Sf9
  38. GP23008 CD5 Human CD5 Human Recombinant
  39. GP23007 CD38 Human CD38 Human Recombinant
  40. GP23006 CD3G Human CD3G Human Recombinant
  41. GP23005 CD3D Human CD3D Human Recombinant
  42. GP23004 CD2 Human, Sf9 CD2 Human Recombinant, sf9
  43. GP23003 CD2 Human, GST CD2 Human Recombinant, GST Tag
  44. GP23002 CD2 Human CD2 Human Recombinant
  45. GP23001 CD1E Human CD1E Human Recombinant
  46. GP23000 CD1D Human CD1D Human Recombinant
  47. GP22999 CD1B Human CD1B Human Recombinant
  48. GP22998 CD1A Human CD1A Human Recombinant
  49. GP22997 CD18 Human CD18 Human Recombinant
  50. GP22996 CD14 Mouse, Sf9 CD14 Mouse Recombinant, Sf9
  51. GP22995 CD14 Mouse CD14 Mouse Recombinant

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