CD59 Human
目录号 : GP23068CD59 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | CD59 Molecule Complement Regulatory Protein; CD59 Antigen P18-20; CD59 Glycoprotein; Surface Anitgen Recognized By Monoclonal Antibody 16.3A5; Membrane Attack Complex (MAC) Inhibition Factor; Lymphocytic Antigen CD59/MEM43; Human Leukocyte Antigen MIC11; Membrane Attack Complex Inhibition Factor; 20 KDa Homologous Restriction Factor; Membrane Inhibitor Of Reactive Lysis; MAC-Inhibitory Protein; T Cell-Activating Protein; Ly-6-Like Protein; Protectin; MIC11; MSK21; MEM43; MIN1/2/3; MIRL; MAC-IP; MACIF; HRF-20; G344; EJ16/30/32; 1F5. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSLQCYNCP NPTADCKTAV NCSSDFDACL ITKAGLQVYN KCWKFEHCNF NDVTTRLREN ELTYYCCKKD LCNFNEQLEN. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. | ||
| Formulation | The CD59 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. | ||
CD59 is a cell surface glycoprotein which regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. CD59 is an effective inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the compilation of this complex, thus inhibiting the incorporation of multiple copies of C9 into the complex, which is essential for osmolytic pore formation. In addition, CD59 has a role in signal transduction pathways in the activation of T cells. CD59 gene mutations cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.
Store at 4°C if entire vial will be used within 2-4 weeks.