CD74 Human
目录号 : GP23037CD74 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | DHLAG; HLADG; Ia-GAMMA; li; HLA-DR antigens-associatedinvariant chain; p33; Ia antigen-associated invariant chain; HLA class IIhistocompatibility antigen gamma chain; CD74; Gamma Chain Of Class II Antigens;MHC HLA-DR Gamma Chain. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSQQQGRLD KLTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP MGALPQGPMQNATKYGNMTE DHVMHLLQNA DPLKVYPPLK GSFPENLRHL KNTMETIDWK VFESWMHHWL LFEMSRHSLEQKPTDAPPKE SLELEDPSSG LGVTKQDLGP VPM | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | CD74 protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.1M NaCl, 30% glycerol and 1mM DTT. | ||
CD74(HLA class II histocompatibility antigen gamma chain isoform b), is a transmembraneprotein (on antigen presenting cells) which is the invariant chain thatchaperones MHC class II dimers from the endoplasmicreticulum to the cell surface. CD74 is expressed by cells of both T lymphocyteand B lymphocyte lineages. CD74 upregulated in several cancersand is also expressed by non immune cells during inflammation. Diseases related with CD74 include thymic epithelial neoplasm andgastroduodenitis. Among its related super-pathways are Immune System and Immuneresponse Antigen presentation by MHC class II. In addition CD74 functions ascell surface receptor for the cytokine MIF.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.