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CD Antigens(CD抗原)

Cell surface antigens of leukocytes are called CD antigens, and important for immune reactions of organisms. As lymphocytes mature, they express different protein receptors on the cell surface, which can aid in determining the type and maturation stage of the cells being examined. These proteins or antigen markers are called Clusters of Differentiation

The term CD means a cluster of differentiation OR a cluster of determinants which indicates the lineage or maturational stage of lymphocytes. During the course of development from precursor cells into functionally mature forms, lymphocytes display a complex pattern of surface antigens, some of which are acquired at certain stages while others are lost.

These surface antigens were identified initially by monoclonal antibodies and the designations of the antibodies were used often as synonyms for the cell surface proteins they detected, giving rise to a plethora of different names. CD antigens are present on some subpopulations and functional types of leukocytes. CD antigens participate in immune reaction as receptors for cell communication (e.g. adherence molecules, antigen recognizing receptors).

CD antigen nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. Numbers are assigned arbitrarily. A small letter w before the number designation stands for "workshop". It indicates that the CD designation is tentative.

CD antigens are found on practically all known cell types. In some cases CD antigens are expressed only at certain stages of development or under certain conditions, for example after cell activation or in certain disease conditions. In Hematology the morphological criteria is for the description of specific developmental stages of lymphocytes unlike in CD antigens which the use of monoclonal antibodies allows the objective and precise analysis and standardized typing of mature and immature normal and malignant cells of all hematopoietic cell lineages. The use antibodies also helps to delineate the biologic traits that distinguish normal immune and hematopoietic cells from their malignant counterparts, which is utmost important in the understanding of hematological malignancies.

The expression of CD antigens is influenced by cytokines, such as binding of ligands to CD antigens which has shown to modulate the expression of cytokines. CD antigens have been shown to be identical with receptors of cytokines such as CD25 (TAC antigen).

CD antigens appear to carry out cytokine receptor-like functions such as CD27, CD30 and CD40. CD antigens are involved in modulating the biological activities of cytokines such as CD4, CD28 and CD40. CD antigens exist also in soluble forms for example CD14, CD21, CD23, CD27, CD100 and CD137.

The CD Antigen’s designation isn’t related to the biological function, thus CD antigens include receptors, glycans, adhesion molecules, membrane-bound enzymes, etc.

The most commonly know CD antigens are CD4 and CD8 which are markers for T-helper and T-suppressor cells, respectively. CD4 binds to relatively invariant sites on class II major histocompatibility complex molecules outside the peptide-binding groove, which interacts with the T-cell receptor. CD4 is also the central docking receptor for human immunodeficiency virus. CD8 binds to relatively invariant sites on class I major histocompatibility complex molecules outside the peptide-binding groove. CD8 is also expressed on a subset of dendritic cells. Other more important CD antigens include the leukocytes integrins (CD11/CD18) and the hematopoietic stem cell marker CD34.

CD69 is homologous to members of a supergene family of type II integral membrane proteins having C-type lectin domains. Although the precise functions of the CD-69 antigen is not known, evidence suggests that these proteins transmit mitogenic signals across the plasma membrane and are up- regulated in response to lymphocyte activation

In the last decade the wide palette of monoclonal antibodies has been prepared which recognise of CD antigens on human cells. Much less monoclonal antibodies are available specific for typing of domestic animal cells. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI).

Products for  CD Antigens

  1. Cat.No. 产品名称 Information
  2. GC74624 Surzebiclimab

    BGB-A425

    Surzebiclimab (BGB-A425)是一种人源化igg1变异单克隆抗体,抗t细胞免疫球蛋白和粘蛋白结构域-3 (TIM-3)。
  3. GC74613 Eftilagimod alfa

    IMP321; LAG-3Ig

    Eftilagimod alfa(IMP321)是一种与MHC II类结合的重组LAG-3Ig融合蛋白。
  4. GC74612 Epcoritamab

    艾可瑞妥单抗; GEN3013

    Epcoritamab (GEN3013)是一种双特异性IgG1抗体,可将t细胞重定向到CD3×CD20+肿瘤细胞。
  5. GC74604 Linvoseltamab

    利伏赛坦单抗; REGN5458

    Linvoseltamab是一种针对BCMA (TNFRSF17)和CD3 epsilon的双特异性抗体。
  6. GC74593 Pasotuxizumab

    帕妥昔珠单抗; BAY 2010112; AMG 212

    Pasotuxizumab (BAY 2010112)是一种PSMA和CD3双特异性t细胞接合器(BiTE)。
  7. GC74591 Pacanalotamab

    AMG 420; BI-836909

    Pacanalotamab (amg 420;BI-836909)是一种靶向BCMA和CD3E的双特异性t细胞接合剂(BiTE)。
  8. GC74589 Ontorpacept

    TTI-621

    Ontorpacept (TTI-621)是一种可溶性融合蛋白,由与人IgG1 Fc区连接的人SIRPα n端(1-118)组成。
  9. GC74588 Plamotamab

    帕拉莫妥单抗; XmAb-13676

    Plamotamab(XmAb-13676)是一种结合CD3和CD20的人双特异性抗体(bsAb)。
  10. GC74586 Obrindatamab

    MGD009

    Obrindatamab是一种人源化抗B7-H3/CD3双特异性抗体。
  11. GC74585 Obexelimab

    奥贝利单抗; XmAb5871

    Obexelimab(XmAb5871)是一种人源化抗CD19抗体。
  12. GC74582 Nivatrotamab

    Hu3F8-BsAb

    Nivatrotamab (Hu3F8-BsAb)是人源抗gd2 /CD3双特异性抗体。
  13. GC74581 Modakafusp alfa

    TAK-573

    Modakafusp alfa (TAK-573)是一种人源化的抗cd38 IgG4单克隆抗体,与2个减毒的IFNα2b分子融合,将干扰素- α传递到表达cd38的细胞。
  14. GC74576 Mezagitamab

    迈泽妥单抗; TAK-079

    Mezagitamab(TAK-079)是一种IgG1λ抗CD38单克隆抗体。
  15. GC74571 Ligufalimab

    莱法利单抗; AK 117

    Ligufalimab(AK 117)是一种人源化IgG4抗CD47单克隆抗体。
  16. GC74548 Flotetuzumab

    伏妥珠单抗; MGD006; S80880

    Flotetuzumab(MGD006;S80880)是一种正在研究的CD123/CD3双特异性双亲和力再靶向抗体(DART)分子。
  17. GC74546 Fianlimab

    弗安利单抗; REGN3767

    Fianlimab(REGN3767)是一种针对T细胞上的免疫检查点受体LAG-3的人单克隆抗体,具有抗肿瘤活性。
  18. GC74545 Favezelimab

    玛维泽利单抗; MK-4280

    Favezelimab (MK-4280)是一种人源化抗LAG-3单克隆抗体,可阻断LAG-3与其配体MHC II类之间的相互作用。
  19. GC74539 Solitomab

    索利托单抗; AMG 110; MT110

    Solitomab(AMG 110)是一种双特异性抗CD3和抗上皮细胞粘附分子(EpCAM)抗体。
  20. GC74531 Catumaxomab

    卡妥索单抗

    Catumaxomab是一种三功能IgG2抗体,由小鼠和大鼠的重链和轻链组成,与人EpCAM和人CD3受体结合。
  21. GC74530 Ubamatamab

    乌巴妥单抗; REGN4018

    Ubamatamab(REGN4018)是一种针对粘蛋白16(MUC16)和CD3的人源化双特异性抗体。
  22. GC74528 Urabrelimab

    SRF-231; SRF231

    Urabrelimab(SRF231)是一种阻断CD47-SIRP相互作用的全人源性抗CD47单克隆抗体。
  23. GC74526 Vepsitamab

    维斯妥单抗; AMG 199

    Vepsitamab(AMG 199)是一种抗MUC17/CD3 BiTE抗体,与T细胞上的CD3和肿瘤细胞上表达的MUC17结合,介导重定向的肿瘤细胞裂解,并诱导T细胞活化和增殖。
  24. GC74525 Vibecotamab

    维克妥单抗; XmAb14045

    Vibecotamab (XmAb14045)是一种有效的针对CD123和CD3的双特异性抗体,可刺激T细胞介导的靶向杀伤表达CD123的细胞。
  25. GC74524 Voxalatamab

    沃昔莱妥单抗; JNJ-63898081

    Voxalatamab(JNJ-63898081)是一种结合PSMA和CD3的双特异性IgG4抗体,具有抗癌活性,用于癌症研究。
  26. GC74498 Teclistamab

    特立妥单抗

    Teclistamab是一种针对BCMA和CD3的人双特异性抗体,其识别靶细胞上的BCMA和T细胞上的CD3,并诱导T细胞介导的细胞毒性,导致T细胞活化和随后的靶细胞裂解。
  27. GC74497 Tepoditamab

    MCLA 117

    Tepoditamab (MCLA-117)是一种双特异性单克隆抗体,可结合骨髓细胞的clecl12a和细胞毒性T细胞的CD3。
  28. GC74494 Gresonitamab

    AMG 910; Anti-Human CD3xClaudin18 2

    Gresonitamab(AMG 910)是一种半衰期延长(HLE)双特异性T细胞接合剂(BiTE)抗体,靶向CD3阳性T细胞和CLDN18.2表达的肿瘤细胞。
  29. GC74449 Vonsetamig Vonsetamig是一种人源免疫球蛋白G4-kappa,抗tnfrsf17和CD3E单克隆抗体。
  30. GC74428 Anzurstobart

    CC-95251; BMS-986351

    Anzurstobart (cc - 95251;BMS-986351)是一种高亲和力的全人源单克隆抗SIRPα抗体,可阻断CD47与SIRPα的结合。
  31. GC73850 Ac5GalNTGc epimer Ac5GalNTGc epimer是己糖胺的类似物和Ac5GalNTGc的外消旋体。
  32. GC73849 Ac5GalNTGc Ac5GalNTGc是己糖胺的类似物。
  33. GC73846 MA3 aptamer sodium MA3 aptamer sodium是一个86碱基长的DNA适体,靶向粘蛋白MUC1。
  34. GC73334 Glutaminyl cyclases-IN-1

    IsoQC-IN-1

    Glutaminyl cyclases-IN-1(IsoQC-IN-1)是一种强效的谷氨酰胺环化酶(QC)抑制剂,对人类QC和IsoQC的IC50值分别为12 nM和73 nM。
  35. GC72443 Pavurutamab Pavurutamab (AMG-701)是一种抗cd3和抗b细胞成熟抗原(BCMA)的双特异性T细胞接合分子。
  36. GC72342 Otelixizumab Otelixizumab(ChAglyCD3)是一种抗人CD3单克隆抗体,可用于1型糖尿病的研究。
  37. GC70011 Teplizumab

    MGA-031; PRV-031

    Teplizumab (MGA-031) 是一种 Fc 受体型、非结合类型的抗-人 CD3 的单克隆抗体。Teplizumab 可缓解 β 细胞的功能丧失。Teplizumab 可用于 type 1 型糖尿病的研究。
  38. GC69985 Talquetamab

    JNJ-64407564

    Talquetamab(JNJ-64407564)是一种人源化的双特异性抗体,可与 GPRC5D (G 蛋白偶联受体家族C5组成员 D) 和 CD3 结合,通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab(JNJ-64407564)具有抗肿瘤活性。
  39. GC69894 Siplizumab

    MEDI-507

    Siplizumab (MEDI-507) 是一种抗 CD2 的人源化 IgG1 单克隆抗体。Siplizumab 可耗尽 T 细胞、降低 T 细胞活化、抑制 T 细胞增殖并富集 naÏve 和 bona fide 调节性 T 细胞。
  40. GC69512 Muromonab

    Muromonab 是一种靶向 CD3 受体的单克隆抗体。Muromonab 可以阻断所有细胞毒性 T 细胞功能。Muromonab 也作为一种免疫抑制剂用于减少急性实体器官移植排斥反应。

  41. GC69453 MethADP triammonium

    Adenosine 5'-(α,β-methylene)diphosphate triammonium

    MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium 是一种 CD73 抑制剂。MethADP 可用于 ATP-腺苷通路的研究。
  42. GC69127 Foralumab

    NI-0401

    Foralumab (NI-0401) 是一种口服有效的人源化单克隆抗体,靶向 CD3。Foralumab 可调节 NSG 小鼠中由人类造血干细胞重建的人类细胞的免疫反应。
  43. GC68858 Cevostamab

    BFCR 4350A; RG 6160; RO 7187797

    Cevostamab (BFCR4350A; RG6160; RO7187797) 是一种人源化、基于 IgG1 的 BsAb,可靶向多发性骨髓瘤 (MM) 细胞上 FcRH5 的近膜端胞外结构域,以及 T 细胞上的 CD3。此外,Cevostamab 促进有效突触的形成,提高 T 细胞对 MM 肿瘤细胞的杀伤活性。
  44. GP26285 ENTPD6 Mouse ENTPD6 Mouse Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (33-455 a
  45. GP26284 ENTPD6 Human ENTPD6 Human Recombinant produced in E
  46. GP26245 CD209 Human CD209 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 587 amino acids (60-404 a
  47. GP26244 CD200 Mouse CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 441 amino acids (31-232aa) and having a molecular mass of 49
  48. GP26243 CD86 Human CD86 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 223 amino acids (31-247a
  49. GP26242 CD72 Human, Sf9 CD72 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 485 amino acids (117-359a
  50. GP26241 CD57 Human CD57 Human Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 549 amino acids (28-334aa) and having a molecular mass of 62
  51. GP26240 CD40 Human, HEK CD40 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing 412 amino acids (21-193 a

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