Cell surface antigens of leukocytes are called CD antigens, and important for immune reactions of organisms. As lymphocytes mature, they express different protein receptors on the cell surface, which can aid in determining the type and maturation stage of the cells being examined. These proteins or antigen markers are called Clusters of Differentiation
The term CD means a cluster of differentiation OR a cluster of determinants which indicates the lineage or maturational stage of lymphocytes. During the course of development from precursor cells into functionally mature forms, lymphocytes display a complex pattern of surface antigens, some of which are acquired at certain stages while others are lost.
These surface antigens were identified initially by monoclonal antibodies and the designations of the antibodies were used often as synonyms for the cell surface proteins they detected, giving rise to a plethora of different names. CD antigens are present on some subpopulations and functional types of leukocytes. CD antigens participate in immune reaction as receptors for cell communication (e.g. adherence molecules, antigen recognizing receptors).
CD antigen nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. Numbers are assigned arbitrarily. A small letter w before the number designation stands for "workshop". It indicates that the CD designation is tentative.
CD antigens are found on practically all known cell types. In some cases CD antigens are expressed only at certain stages of development or under certain conditions, for example after cell activation or in certain disease conditions. In Hematology the morphological criteria is for the description of specific developmental stages of lymphocytes unlike in CD antigens which the use of monoclonal antibodies allows the objective and precise analysis and standardized typing of mature and immature normal and malignant cells of all hematopoietic cell lineages. The use antibodies also helps to delineate the biologic traits that distinguish normal immune and hematopoietic cells from their malignant counterparts, which is utmost important in the understanding of hematological malignancies.
The expression of CD antigens is influenced by cytokines, such as binding of ligands to CD antigens which has shown to modulate the expression of cytokines. CD antigens have been shown to be identical with receptors of cytokines such as CD25 (TAC antigen).
CD antigens appear to carry out cytokine receptor-like functions such as CD27, CD30 and CD40. CD antigens are involved in modulating the biological activities of cytokines such as CD4, CD28 and CD40. CD antigens exist also in soluble forms for example CD14, CD21, CD23, CD27, CD100 and CD137.
The CD Antigen’s designation isn’t related to the biological function, thus CD antigens include receptors, glycans, adhesion molecules, membrane-bound enzymes, etc.
The most commonly know CD antigens are CD4 and CD8 which are markers for T-helper and T-suppressor cells, respectively. CD4 binds to relatively invariant sites on class II major histocompatibility complex molecules outside the peptide-binding groove, which interacts with the T-cell receptor. CD4 is also the central docking receptor for human immunodeficiency virus. CD8 binds to relatively invariant sites on class I major histocompatibility complex molecules outside the peptide-binding groove. CD8 is also expressed on a subset of dendritic cells. Other more important CD antigens include the leukocytes integrins (CD11/CD18) and the hematopoietic stem cell marker CD34.
CD69 is homologous to members of a supergene family of type II integral membrane proteins having C-type lectin domains. Although the precise functions of the CD-69 antigen is not known, evidence suggests that these proteins transmit mitogenic signals across the plasma membrane and are up- regulated in response to lymphocyte activation
In the last decade the wide palette of monoclonal antibodies has been prepared which recognise of CD antigens on human cells. Much less monoclonal antibodies are available specific for typing of domestic animal cells. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI).
Products for CD Antigens
- Fc Fragment of IgG Receptor(5)
- Other CD Antigens(46)
- Cat.No. 产品名称 Information
- GP26285 ENTPD6 Mouse ENTPD6 Mouse Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (33-455 a
- GP26284 ENTPD6 Human ENTPD6 Human Recombinant produced in E
- GP26245 CD209 Human CD209 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 587 amino acids (60-404 a
- GP26244 CD200 Mouse CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 441 amino acids (31-232aa) and having a molecular mass of 49
- GP26243 CD86 Human CD86 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 223 amino acids (31-247a
- GP26242 CD72 Human, Sf9 CD72 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 485 amino acids (117-359a
- GP26241 CD57 Human CD57 Human Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 549 amino acids (28-334aa) and having a molecular mass of 62
- GP26240 CD40 Human, HEK CD40 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing 412 amino acids (21-193 a
- GP26239 CD276 Mouse CD276 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 226 amino acids (29-248a
- GP26238 CD27 Human, HEK CD27 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (20-191 a
- GP26237 CD21 Human CD21 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 959 amino acids (21-971aa) and having a molecular mass of 105
- GP26236 CD9 Human, HEK CD9 Human Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 93 amino acids (112-195a
- GP26235 CD9 Human, Sf9 CD9 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 326 amino acids (112-195a
- GP26234 CD8A Human CD8A Human Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 170 amino acids (22-182aa) and having a molecular mass of 18
- GP26233 CD6 Human CD6 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 627 amino acids (18-402a
- GP26202 ALCAM (CD166) Mouse ALCAM mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 739 amino acids (28-527a
- GP26070 sCD40L Human, His Active sCD40L Human Recombinant produced in E
- GC65470 Oleclumab
- GC65293 AB-680
- GC62695 OP-5244 sodium
- GC62694 OP-5244
- GC62452 CD73-IN-4
- GC62331 CD73-IN-3 LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).
- GP24134 CD163 Porcine CD163 Porcine Recombinant
- GP24133 CD163 Human CD163 Human Recombinant
- GP24070 NT5E (CD73) Mouse 5'-Nucleotidase Ecto (CD73) Mouse Recombinant
- GP24069 NT5E (CD73) Human 5'-Nucleotidase Ecto (CD73) Human Recombinant
- GP23966 MS4A1 Human Membrane Spanning 4-Domains A1 Human Recombinant
- GP23965 MSR1 Human, sf9 Macrophage Scavenger Receptor 1, sf9 Human Recombinant
- GP23964 MSR1 Human Macrophage Scavenger Receptor 1 Human Recombinant
- GP23696 IGLL1 Human Immunoglobulin Lambda-Like Polypeptide 1 Human Recombinant
- GP23483 FCGR3B Human CD16b Human Recombinant
- GP23482 FCGR3A Human, Sf9 CD16a Human Recombinant, Sf9
- GP23481 FCGR3A Human CD16a Human Recombinant
- GP23480 FCGR2B Human CD32 Human Recombinant
- GP23479 FCGR2A Human CD32a Human Recombinant
- GP23236 CRTAM Human Cytotoxic and Regulatory T Cell Molecule Human Recombinant
- GP23096 CD300E Human CD300E Human Recombinant
- GP23095 CD300A Human CD300A Human Recombinant
- GP23094 CD207 Human, sf9 CD207 Human Recombinant, sf9
- GP23093 CD207 Human CD207 Human Recombinant
- GP23092 CD200R1 Mouse CD200 Receptor 1 Mouse Recombinant
- GP23091 CD200R1 Human CD200 Receptor 1 Human Recombinant
- GP23090 CD200 Human, Sf9 CD200 Human Recombinant, sf9
- GP23089 CD200 Human CD200 Human Recombinant
- GP23088 CD160 Human CD160 Human Recombinant
- GP23087 CD100 Human HEK CD100 Human Recombinant HEK
- GP23086 CD99 Human, Sf9 CD99 Human Recombinant, Sf9
- GP23084 CD96 Human CD96 Human Recombinant
- GP23083 CD93 Mouse CD93 Mouse Recombinant