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CD Antigens(CD抗原)

Cell surface antigens of leukocytes are called CD antigens, and important for immune reactions of organisms. As lymphocytes mature, they express different protein receptors on the cell surface, which can aid in determining the type and maturation stage of the cells being examined. These proteins or antigen markers are called Clusters of Differentiation

The term CD means a cluster of differentiation OR a cluster of determinants which indicates the lineage or maturational stage of lymphocytes. During the course of development from precursor cells into functionally mature forms, lymphocytes display a complex pattern of surface antigens, some of which are acquired at certain stages while others are lost.

These surface antigens were identified initially by monoclonal antibodies and the designations of the antibodies were used often as synonyms for the cell surface proteins they detected, giving rise to a plethora of different names. CD antigens are present on some subpopulations and functional types of leukocytes. CD antigens participate in immune reaction as receptors for cell communication (e.g. adherence molecules, antigen recognizing receptors).

CD antigen nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. Numbers are assigned arbitrarily. A small letter w before the number designation stands for "workshop". It indicates that the CD designation is tentative.

CD antigens are found on practically all known cell types. In some cases CD antigens are expressed only at certain stages of development or under certain conditions, for example after cell activation or in certain disease conditions. In Hematology the morphological criteria is for the description of specific developmental stages of lymphocytes unlike in CD antigens which the use of monoclonal antibodies allows the objective and precise analysis and standardized typing of mature and immature normal and malignant cells of all hematopoietic cell lineages. The use antibodies also helps to delineate the biologic traits that distinguish normal immune and hematopoietic cells from their malignant counterparts, which is utmost important in the understanding of hematological malignancies.

The expression of CD antigens is influenced by cytokines, such as binding of ligands to CD antigens which has shown to modulate the expression of cytokines. CD antigens have been shown to be identical with receptors of cytokines such as CD25 (TAC antigen).

CD antigens appear to carry out cytokine receptor-like functions such as CD27, CD30 and CD40. CD antigens are involved in modulating the biological activities of cytokines such as CD4, CD28 and CD40. CD antigens exist also in soluble forms for example CD14, CD21, CD23, CD27, CD100 and CD137.

The CD Antigen’s designation isn’t related to the biological function, thus CD antigens include receptors, glycans, adhesion molecules, membrane-bound enzymes, etc.

The most commonly know CD antigens are CD4 and CD8 which are markers for T-helper and T-suppressor cells, respectively. CD4 binds to relatively invariant sites on class II major histocompatibility complex molecules outside the peptide-binding groove, which interacts with the T-cell receptor. CD4 is also the central docking receptor for human immunodeficiency virus. CD8 binds to relatively invariant sites on class I major histocompatibility complex molecules outside the peptide-binding groove. CD8 is also expressed on a subset of dendritic cells. Other more important CD antigens include the leukocytes integrins (CD11/CD18) and the hematopoietic stem cell marker CD34.

CD69 is homologous to members of a supergene family of type II integral membrane proteins having C-type lectin domains. Although the precise functions of the CD-69 antigen is not known, evidence suggests that these proteins transmit mitogenic signals across the plasma membrane and are up- regulated in response to lymphocyte activation

In the last decade the wide palette of monoclonal antibodies has been prepared which recognise of CD antigens on human cells. Much less monoclonal antibodies are available specific for typing of domestic animal cells. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI).

Products for  CD Antigens

  1. Cat.No. 产品名称 Information
  2. GC70011 Teplizumab Teplizumab (MGA-031) 是一种 Fc 受体型、非结合类型的抗-人 CD3 的单克隆抗体。Teplizumab 可缓解 β 细胞的功能丧失。Teplizumab 可用于 type 1 型糖尿病的研究。
  3. GC69985 Talquetamab Talquetamab(JNJ-64407564)是一种人源化的双特异性抗体,可与 GPRC5D (G 蛋白偶联受体家族C5组成员 D) 和 CD3 结合,通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab(JNJ-64407564)具有抗肿瘤活性。
  4. GC69894 Siplizumab Siplizumab (MEDI-507) 是一种抗 CD2 的人源化 IgG1 单克隆抗体。Siplizumab 可耗尽 T 细胞、降低 T 细胞活化、抑制 T 细胞增殖并富集 naÏve 和 bona fide 调节性 T 细胞。
  5. GC69512 Muromonab

    Muromonab 是一种靶向 CD3 受体的单克隆抗体。Muromonab 可以阻断所有细胞毒性 T 细胞功能。Muromonab 也作为一种免疫抑制剂用于减少急性实体器官移植排斥反应。

  6. GC69453 MethADP triammonium MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium 是一种 CD73 抑制剂。MethADP 可用于 ATP-腺苷通路的研究。
  7. GC69127 Foralumab Foralumab (NI-0401) 是一种口服有效的人源化单克隆抗体,靶向 CD3。Foralumab 可调节 NSG 小鼠中由人类造血干细胞重建的人类细胞的免疫反应。
  8. GC68858 Cevostamab Cevostamab (BFCR4350A; RG6160; RO7187797) 是一种人源化、基于 IgG1 的 BsAb,可靶向多发性骨髓瘤 (MM) 细胞上 FcRH5 的近膜端胞外结构域,以及 T 细胞上的 CD3。此外,Cevostamab 促进有效突触的形成,提高 T 细胞对 MM 肿瘤细胞的杀伤活性。
  9. GP26285 ENTPD6 Mouse ENTPD6 Mouse Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (33-455 a
  10. GP26284 ENTPD6 Human ENTPD6 Human Recombinant produced in E
  11. GP26245 CD209 Human CD209 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 587 amino acids (60-404 a
  12. GP26244 CD200 Mouse CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 441 amino acids (31-232aa) and having a molecular mass of 49
  13. GP26243 CD86 Human CD86 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 223 amino acids (31-247a
  14. GP26242 CD72 Human, Sf9 CD72 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 485 amino acids (117-359a
  15. GP26241 CD57 Human CD57 Human Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 549 amino acids (28-334aa) and having a molecular mass of 62
  16. GP26240 CD40 Human, HEK CD40 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing 412 amino acids (21-193 a
  17. GP26239 CD276 Mouse CD276 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 226 amino acids (29-248a
  18. GP26238 CD27 Human, HEK CD27 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (20-191 a
  19. GP26237 CD21 Human CD21 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 959 amino acids (21-971aa) and having a molecular mass of 105
  20. GP26236 CD9 Human, HEK CD9 Human Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 93 amino acids (112-195a
  21. GP26235 CD9 Human, Sf9 CD9 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 326 amino acids (112-195a
  22. GP26234 CD8A Human CD8A Human Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 170 amino acids (22-182aa) and having a molecular mass of 18
  23. GP26233 CD6 Human CD6 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 627 amino acids (18-402a
  24. GP26202 ALCAM (CD166) Mouse ALCAM mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 739 amino acids (28-527a
  25. GP26070 sCD40L Human, His Active sCD40L Human Recombinant produced in E
  26. GC68386 CD73-IN-5 CD73-IN-5 是一种有效且选择性的非核苷酸小分子 CD73 抑制剂(IC50 = 19 nM)。
  27. GC68346 Uliledlimab Uliledlimab 是一种有效的抗 CD73 人源单克隆抗体。Uliledlimab 抑制胞外单磷酸腺苷 (AMP) 向腺苷的转化。Uliledlimab 可用于癌症的研究。
  28. GC68344 Mupadolimab Mupadolimab (CPI-006) 是一种 IgG1κ 人源化的 FcγR 结合缺陷抗 CD73 单抗,激活 CD73POS B 细胞。
  29. GC65470 Oleclumab Oleclumab (MEDI9447) 是一种人 IgG1Λ 抗 CD73 单克隆抗体,可抑制 CD73 功能。Oleclumab 具有抗肿瘤活性。
  30. GC65293 AB-680 AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂,对 hCD73 的 Ki 值为 4.9 pM,对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。
  31. GC62695 OP-5244 sodium OP-5244 sodium 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 sodium 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
  32. GC62694 OP-5244 OP-5244 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
  33. GC62452 CD73-IN-4 CD73-IN-4 是一种高效、选择性的亚甲基膦酸 CD73 抑制剂,对人 CD73 作用的 IC50 值为 2.6 nM。CD73-IN-4 在癌症免疫学研究中具有潜在的应用价值。
  34. GC62331 CD73-IN-3 LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).
  35. GP24134 CD163 Porcine CD163 Porcine Recombinant
  36. GP24133 CD163 Human CD163 Human Recombinant
  37. GP24070 NT5E (CD73) Mouse 5'-Nucleotidase Ecto (CD73) Mouse Recombinant
  38. GP24069 NT5E (CD73) Human 5'-Nucleotidase Ecto (CD73) Human Recombinant
  39. GP23966 MS4A1 Human Membrane Spanning 4-Domains A1 Human Recombinant
  40. GP23965 MSR1 Human, sf9 Macrophage Scavenger Receptor 1, sf9 Human Recombinant
  41. GP23964 MSR1 Human Macrophage Scavenger Receptor 1 Human Recombinant
  42. GP23696 IGLL1 Human Immunoglobulin Lambda-Like Polypeptide 1 Human Recombinant
  43. GP23483 FCGR3B Human CD16b Human Recombinant
  44. GP23482 FCGR3A Human, Sf9 CD16a Human Recombinant, Sf9
  45. GP23481 FCGR3A Human CD16a Human Recombinant
  46. GP23480 FCGR2B Human CD32 Human Recombinant
  47. GP23479 FCGR2A Human CD32a Human Recombinant
  48. GP23478 FCGR1A Human CD64 Human Recombinant
  49. GP23236 CRTAM Human Cytotoxic and Regulatory T Cell Molecule Human Recombinant
  50. GP23096 CD300E Human CD300E Human Recombinant
  51. GP23095 CD300A Human CD300A Human Recombinant

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