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CD Antigens(CD抗原)

Cell surface antigens of leukocytes are called CD antigens, and important for immune reactions of organisms. As lymphocytes mature, they express different protein receptors on the cell surface, which can aid in determining the type and maturation stage of the cells being examined. These proteins or antigen markers are called Clusters of Differentiation

The term CD means a cluster of differentiation OR a cluster of determinants which indicates the lineage or maturational stage of lymphocytes. During the course of development from precursor cells into functionally mature forms, lymphocytes display a complex pattern of surface antigens, some of which are acquired at certain stages while others are lost.

These surface antigens were identified initially by monoclonal antibodies and the designations of the antibodies were used often as synonyms for the cell surface proteins they detected, giving rise to a plethora of different names. CD antigens are present on some subpopulations and functional types of leukocytes. CD antigens participate in immune reaction as receptors for cell communication (e.g. adherence molecules, antigen recognizing receptors).

CD antigen nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. Numbers are assigned arbitrarily. A small letter w before the number designation stands for "workshop". It indicates that the CD designation is tentative.

CD antigens are found on practically all known cell types. In some cases CD antigens are expressed only at certain stages of development or under certain conditions, for example after cell activation or in certain disease conditions. In Hematology the morphological criteria is for the description of specific developmental stages of lymphocytes unlike in CD antigens which the use of monoclonal antibodies allows the objective and precise analysis and standardized typing of mature and immature normal and malignant cells of all hematopoietic cell lineages. The use antibodies also helps to delineate the biologic traits that distinguish normal immune and hematopoietic cells from their malignant counterparts, which is utmost important in the understanding of hematological malignancies.

The expression of CD antigens is influenced by cytokines, such as binding of ligands to CD antigens which has shown to modulate the expression of cytokines. CD antigens have been shown to be identical with receptors of cytokines such as CD25 (TAC antigen).

CD antigens appear to carry out cytokine receptor-like functions such as CD27, CD30 and CD40. CD antigens are involved in modulating the biological activities of cytokines such as CD4, CD28 and CD40. CD antigens exist also in soluble forms for example CD14, CD21, CD23, CD27, CD100 and CD137.

The CD Antigen’s designation isn’t related to the biological function, thus CD antigens include receptors, glycans, adhesion molecules, membrane-bound enzymes, etc.

The most commonly know CD antigens are CD4 and CD8 which are markers for T-helper and T-suppressor cells, respectively. CD4 binds to relatively invariant sites on class II major histocompatibility complex molecules outside the peptide-binding groove, which interacts with the T-cell receptor. CD4 is also the central docking receptor for human immunodeficiency virus. CD8 binds to relatively invariant sites on class I major histocompatibility complex molecules outside the peptide-binding groove. CD8 is also expressed on a subset of dendritic cells. Other more important CD antigens include the leukocytes integrins (CD11/CD18) and the hematopoietic stem cell marker CD34.

CD69 is homologous to members of a supergene family of type II integral membrane proteins having C-type lectin domains. Although the precise functions of the CD-69 antigen is not known, evidence suggests that these proteins transmit mitogenic signals across the plasma membrane and are up- regulated in response to lymphocyte activation

In the last decade the wide palette of monoclonal antibodies has been prepared which recognise of CD antigens on human cells. Much less monoclonal antibodies are available specific for typing of domestic animal cells. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatidylinositol (GPI).

Products for  CD Antigens

  1. Cat.No. 产品名称 Information
  2. GC65470 Oleclumab Oleclumab (MEDI9447) 是一种人 IgG1Λ 抗 CD73 单克隆抗体,可抑制 CD73 功能。Oleclumab 具有抗肿瘤活性。
  3. GC65293 AB-680 AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂,对 hCD73 的 Ki 值为 4.9 pM,对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。
  4. GC62695 OP-5244 sodium OP-5244 sodium 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 sodium 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
  5. GC62694 OP-5244 OP-5244 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
  6. GC62452 CD73-IN-4 CD73-IN-4 是一种高效、选择性的亚甲基膦酸 CD73 抑制剂,对人 CD73 作用的 IC50 值为 2.6 nM。CD73-IN-4 在癌症免疫学研究中具有潜在的应用价值。
  7. GC62331 CD73-IN-3 CD73-IN-3 是一种有效的 CD73 抑制剂(IC50; Calu6 人细胞实验中)。CD73-IN-3,例 2 源自专利 WO2019168744 A1,具有研究癌症的潜力。
  8. GP24134 CD163 Porcine CD163 Porcine Recombinant
  9. GP24133 CD163 Human CD163 Human Recombinant
  10. GP24070 NT5E (CD73) Mouse 5'-Nucleotidase Ecto (CD73) Mouse Recombinant
  11. GP24069 NT5E (CD73) Human 5'-Nucleotidase Ecto (CD73) Human Recombinant
  12. GP23966 MS4A1 Human Membrane Spanning 4-Domains A1 Human Recombinant
  13. GP23965 MSR1 Human, sf9 Macrophage Scavenger Receptor 1, sf9 Human Recombinant
  14. GP23964 MSR1 Human Macrophage Scavenger Receptor 1 Human Recombinant
  15. GP23696 IGLL1 Human Immunoglobulin Lambda-Like Polypeptide 1 Human Recombinant
  16. GP23483 FCGR3B Human CD16b Human Recombinant
  17. GP23482 FCGR3A Human, Sf9 CD16a Human Recombinant, Sf9
  18. GP23481 FCGR3A Human CD16a Human Recombinant
  19. GP23480 FCGR2B Human CD32 Human Recombinant
  20. GP23479 FCGR2A Human CD32a Human Recombinant
  21. GP23478 FCGR1A Human CD64 Human Recombinant
  22. GP23236 CRTAM Human Cytotoxic and Regulatory T Cell Molecule Human Recombinant
  23. GP23096 CD300E Human CD300E Human Recombinant
  24. GP23095 CD300A Human CD300A Human Recombinant
  25. GP23094 CD207 Human, sf9 CD207 Human Recombinant, sf9
  26. GP23093 CD207 Human CD207 Human Recombinant
  27. GP23092 CD200R1 Mouse CD200 Receptor 1 Mouse Recombinant
  28. GP23091 CD200R1 Human CD200 Receptor 1 Human Recombinant
  29. GP23090 CD200 Human, Sf9 CD200 Human Recombinant, sf9
  30. GP23089 CD200 Human CD200 Human Recombinant
  31. GP23088 CD160 Human CD160 Human Recombinant
  32. GP23087 CD100 Human HEK CD100 Human Recombinant HEK
  33. GP23086 CD99 Human, Sf9 CD99 Human Recombinant, Sf9
  34. GP23085 CD99 Human CD99 Human Recombinant
  35. GP23084 CD96 Human CD96 Human Recombinant
  36. GP23083 CD93 Mouse CD93 Mouse Recombinant
  37. GP23082 CD93 Human CD93 Human Recombinant
  38. GP23081 CD90 Human Thy-1 Cell Surface Antigen Human Recombinant
  39. GP23080 CD84 Human, Sf9 CD84 Human Recombinant, Sf9
  40. GP23079 CD84 Human CD84 Human Recombinant
  41. GP23078 CD83 Human CD83 Human Recombinant
  42. GP23077 CD81 Human CD81 Human Recombinant
  43. GP23076 CD79B Human, Sf9 CD79B Human Recombinant, Sf9
  44. GP23075 CD79B Human CD79B Human Recombinant
  45. GP23074 CD79A Human CD79A Human Recombinant
  46. GP23073 CD72 Human CD72 Human Recombinant
  47. GP23072 CD69 Human CD69 Human Recombinant
  48. GP23071 CD68 Human, sf9 CD68 Human Recombinant, sf9
  49. GP23070 CD68 Human, 38kDa CD68 Human Recombinant, 38kDa
  50. GP23069 CD68 Human CD68 Human Recombinant
  51. GP23068 CD59 Human CD59 Human Recombinant

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