Ginkgetin
(Synonyms: 银杏双黄酮) 目录号 : GC31717
Ginkgetin一种从银杏叶中提取的双黄酮类天然化合物，能够抑制Wnt信号通路（IC₅₀=5.92μM）。
Cas No.:481-46-9
Sample solution is provided at 25 µL, 10mM.
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Ginkgetin is a natural biflavonoid compound extracted from Ginkgo biloba leaves, inhibits the Wnt signaling pathway (IC₅₀=5.92μM)[1]. Ginkgetin exhibits multiple pharmacological activities, including anticancer, anti-inflammatory, antimicrobial, antioxidant, and neuroprotective effects[2]. Ginkgetin can be used to treat coronary heart disease, angina pectoris, and hypertension[3-4].
In vitro, co-treatment of A549, NCI-H460, and SPC-A-1 non-small cell lung cancer cells with Ginkgetin (5μM) and Cisplatin (5μM) for 48 hours significantly induces ferroptosis and enhances the cytotoxic effects of Cisplatin[5]. Treatment of ovarian cancer cells A2780, SK-OV-3, and CP70 with Ginkgetin (0.625–80μM) for 24 hours significantly inhibits cell proliferation, induces apoptosis, and reduces cell migration and invasion capabilities[6].
In vivo, intraperitoneal injection of Ginkgetin (5mg/kg) every other day for 2 months in a Doxorubicin (Dox; 10mg/kg)-induced aging C57BL/6J mouse model significantly alleviates aging-related pathological changes in multiple tissues (including kidney, liver, muscle, and spleen) and improves motor function[7]. Oral administration of Ginkgetin (25, 50, 100mg/kg) twice weekly for 8 weeks in ovariectomized (OVX) C57BL/6J mice significantly attenuates bone loss[8].
References:
[1] Ye ZN, Yu MY, Kong LM, et al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91–7.
[2] Liu XG, Lu X, Gao W, et al. Structure, synthesis, biosynthesis, and activity of the characteristic compounds from Ginkgo biloba L. Nat Prod Rep. 2022 Mar 23;39(3):474-511.
[3] Xiong B, Lu JJ, Guo H, et al. Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy. Nat Prod Bioprospect. 2025 Aug 5;15(1):50.
[4] Adnan M, Rasul A, Hussain G, et al. Ginkgetin: A natural biflavone with versatile pharmacological activities. Food Chem Toxicol. 2020 Nov;145:111642.
[5] Lou JS, Zhao LP, Huang ZH, et al. Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine. 2021 Jan;80:153370.
[6] Liu Y, Ye J, Fan Z, et al. Ginkgetin Alleviates Inflammation and Senescence by Targeting STING. Adv Sci (Weinh). 2025 Jan;12(2):e2407222.
[7] Geng Z, Zuo L, Li J, et al. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB J. 2024 Jul 31;38(14):e23817.
[8] Wei G, Liang X, Wu F, et al. Ginkgetin attenuates bone loss in OVX mice by inhibiting the NF-κB/IκBα signaling pathway. PeerJ. 2024 Jul 10;12:e17722.
Ginkgetin一种从银杏叶中提取的双黄酮类天然化合物，能够抑制Wnt信号通路（IC₅₀=5.92μM）[1]。Ginkgetin有抗癌、抗炎、抗菌、抗氧化和神经保护等多种药理活性[2]。Ginkgetin可用于治疗冠心病、心绞痛以及高血压等疾病[3-4]。
在体外，Ginkgetin（5μM）与Cisplatin（5μM）联合处理A549、NCI-H460和SPC-A-1非小细胞肺癌细胞48小时，显著诱导铁死亡，同时增强Cisplatin的细胞毒性作用[5]。Ginkgetin（0.625–80μM）处理卵巢癌细胞A2780、SK-OV-3和CP70 24小时，显著抑制细胞增殖并诱导细胞凋亡，同时降低细胞迁移和侵袭能力[6]。
在体内，Ginkgetin（5mg/kg）每隔一天腹腔注射一次，持续2个月，用于处理经Doxorubicin（Dox；10mg/kg）诱导的衰老C57BL/6J小鼠。Ginkgetin显著减轻了多个组织（包括肾脏、肝脏、肌肉和脾脏）的衰老相关病理变化，并改善了小鼠的运动能力[7]。Ginkgetin（25、50、100mg/kg）每周两次口服给药，持续8周，用于处理卵巢切除（OVX）的C57BL/6J小鼠，显著减轻了小鼠的骨丢失[8]。
| Cell experiment [1]: | |
Cell lines | A2780, SK-OV-3, and CP70 (human ovarian cancer cell lines); KGN (human ovarian granulosa cell-like) and H9c2 (rat cardiomyocytes) as normal controls |
Preparation Method | OC cells and normal cells were cultured in high-glucose DMEM medium supplemented with 10% FBS at 37°C, 5% CO₂. Cells were treated with Ginkgetin at concentrations of 0.625–80μM for 24 hours. |
Reaction Conditions | 0.625–80μM; 24h |
Applications | Ginkgetin dose-dependently inhibited proliferation, migration, and invasion of OC cells, and induced apoptosis via downregulation of Bcl-2 and upregulation of Bax/p53. Ginkgetin suppressed JAK2/STAT3 and MAPK signaling pathways and reduced SIRT1 protein expression. |
| Animal experiment [2]: | |
Animal models | C57BL/6J female mice |
Preparation Method | Mice underwent ovariectomy (OVX) to induce bone loss. Ginkgetin (25–100mg/kg) was orally administered twice weekly for 8 weeks. |
Dosage form | 25–100mg/kg; orally administered; for 8 weeks |
Applications | In OVX mice, Ginkgetin attenuated bone loss by improving bone density (BMD, BV/TV) and trabecular structure, suppressing osteoclast formation via inhibition of NF-κB/IκBα signaling, and reducing osteoclast-related genes. |
References: | |
| Cas No. | 481-46-9 | SDF | |
| 别名 | 银杏双黄酮 | ||
| Canonical SMILES | OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1C4=CC(C(OC5=CC(OC)=CC(O)=C56)=CC6=O)=CC=C4OC | ||
| 分子式 | C32H22O10 | 分子量 | 566.51 |
| 溶解度 | DMSO : ≥ 83.3 mg/mL (147.04 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7652 mL | 8.826 mL | 17.6519 mL |
| 5 mM | 353 μL | 1.7652 mL | 3.5304 mL |
| 10 mM | 176.5 μL | 882.6 μL | 1.7652 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet