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Clomipramine HCl Sale

(Synonyms: 盐酸氯米帕明; Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride) 目录号 : GC15107

A tricyclic antidepressant

Clomipramine HCl Chemical Structure

Cas No.:17321-77-6

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥357.00
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50mg
¥483.00
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产品描述

Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.

Clomipramine hydrochloride is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant. Clomipramine hydrochloride is a norepinephrine-reuptake inhibitor and is an antiobsessional drug. Clomipramine hydrochloride is an antagonist/inverse agonist at the following receptors: D2 receptor (Ki=162 nM), D3 receptor (Ki=30 nM), α1-adrenergic receptor (Ki=3.2 nM), α2-adrenergic receptor (Ki=525 nM), H1 receptor (Ki=31 nM), mACh receptors (Ki=37 nM), 5-HT2A receptor (Ki=36 nM), 5-HT2C receptor (Ki=65 nM), 5-HT3 receptor (Ki=85 nM), 5-HT6 receptor (Ki=54 nM), 5-HT7 receptor (Ki=127 nM), D1 receptor (Ki=219 nM)[1][2][3].

References:
[1]. McTavish, D. and P. Benfield, Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs, 1990. 39(1): p. 136-53.
[2]. Ortiz, J. and F. Artigas, Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. Br J Pharmacol, 1992. 105(4): p. 941-6.
[3]. Owens, M.J., et al., Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther, 1997. 283(3): p. 1305-22.

Chemical Properties

Cas No. 17321-77-6 SDF
别名 盐酸氯米帕明; Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride
化学名 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Canonical SMILES CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
分子式 C19H23ClN2.HCl 分子量 351.31
溶解度 ≥ 17.6mg/mL in DMSO 储存条件 Store at RT
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1 mg 5 mg 10 mg
1 mM 2.8465 mL 14.2324 mL 28.4649 mL
5 mM 0.5693 mL 2.8465 mL 5.693 mL
10 mM 0.2846 mL 1.4232 mL 2.8465 mL
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