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Bis(2-bromoethyl) ether Sale

(Synonyms: 2,2'-二溴二乙醚) 目录号 : GC61418

Bis2-bromoethylether是一种PROTAClinker,属于alkylchain类。可用于合成PROTAC分子。

Bis(2-bromoethyl) ether Chemical Structure

Cas No.:5414-19-7

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500 mg
¥315.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical Properties

Cas No. 5414-19-7 SDF
别名 2,2'-二溴二乙醚
Canonical SMILES BrCCOCCBr
分子式 C4H8Br2O 分子量 231.92
溶解度 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.3118 mL 21.5592 mL 43.1183 mL
5 mM 0.8624 mL 4.3118 mL 8.6237 mL
10 mM 0.4312 mL 2.1559 mL 4.3118 mL
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Research Update

An amino alcohol ligand for highly enantioselective addition of organozinc reagents to aldehydes: serendipity rules

Org Lett 2002 Jun 27;4(13):2133-6.PMID:12074650DOI:10.1021/ol0259488

[reaction: see text] Amino alcohol 4 (or its enantiomer) is prepared in two simple steps. Commercial (1R,2S)-2-amino-1,2-diphenylethanol is dialkylated with Bis(2-bromoethyl) ether. Subsequent hydrogenation over 5% Rh on alumina in the presence of morpholine unexpectedly stops at the hexahydro derivative 4. Amino alcohol 4 promotes the enantioselective addition of diethylzinc to aldehydes at room temperature in up to 99% enantiomeric excess.