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L-Cysteinesulfinic Acid (hydrate) Sale

(Synonyms: L-半胱氨酸亚磺酸一水合物) 目录号 : GC46165

An excitatory amino acid and mGluR agonist

L-Cysteinesulfinic Acid (hydrate) Chemical Structure

Cas No.:207121-48-0

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25mg
¥428.00
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50mg
¥823.00
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100mg
¥1,542.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs).1,2 It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively).2 It selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS).1 L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.3

|1. Takemoto, Y. Cardiovascular actions of L-cysteine and L-cysteine sulfinic acid in the nucleus tractus solitarius of the rat. Amino Acids 46(7), 1707-1713 (2014).|2. Shi, Q., Savage, J.E., Hufeisen, S.J., et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J. Pharmacol. Exp. Ther. 305(1), 131-142 (2003).|3. Keng, C.-L., Lin, Y.-C., Tseng, W.-L., et al. Design of peptide-based probes for the microscale detection of reactive oxygen species. Anal. Chem. 89(20), 10883-10888 (2017).

Chemical Properties

Cas No. 207121-48-0 SDF
别名 L-半胱氨酸亚磺酸一水合物
Canonical SMILES OC([C@@H](N)CS(O)=O)=O.O
分子式 C3H7NO4S • H2O 分子量 171.2
溶解度 DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 5.8411 mL 29.2056 mL 58.4112 mL
5 mM 1.1682 mL 5.8411 mL 11.6822 mL
10 mM 0.5841 mL 2.9206 mL 5.8411 mL
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