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Artemisinine Sale

(Synonyms: 青蒿素; Qinghaosu; NSC 369397) 目录号 : GN10647

An antimalarial agent with anticancer activity

Artemisinine Chemical Structure

Cas No.:63968-64-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥516.00
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200mg
¥469.00
现货
500mg
¥781.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells[1]. Artemisinin (1-100 μM; 24  hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC50 values of 31.30 ± 0.73 μM in UMRC-2 cells and 23.97 ± 0.92 CAKI-2 cells[2]. Artemisinin (25, 50 μM; 24 hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner[2].

Artemisinin (gavage; 20 mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth[2].

References:
[1]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.
[2]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

Chemical Properties

Cas No. 63968-64-9 SDF
别名 青蒿素; Qinghaosu; NSC 369397
化学名 (5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(12H)-one
Canonical SMILES O=C1O[C@]2([H])OC3(C([H])([H])[H])OO[C@]42[C@](C([H])([H])C3([H])[H])([H])[C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])[C@@]4([H])[C@@]1([H])C([H])([H])[H]
分子式 C15H22O5 分子量 282.33
溶解度 ≥ 13.7mg/mL in DMSO 储存条件 Store at 2-8°C
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1 mg 5 mg 10 mg
1 mM 3.542 mL 17.7098 mL 35.4195 mL
5 mM 0.7084 mL 3.542 mL 7.0839 mL
10 mM 0.3542 mL 1.771 mL 3.542 mL
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