Home >> Signaling Pathways >> Proteases >> MMP


Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

  1. Cat.No. Product Name Information
  2. GC41552 ω-3 Arachidonic Acid ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources.
  3. GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS.
  4. GC17242 (-)-epigallocatechin green tea epicatechin
  5. GN10783 (R) Ginsenoside Rh2 Extracted from Panax ginseng C. A. Mey. dried roots;Store the product in sealed, cool and dry condition
  6. GC45978 1,10-Phenanthroline (hydrate)
  7. GC41776 1,2,3-Trioleoyl-rac-glycerol 1,2,3-Trioleoyl-rac-glycerol is a triacylglycerol that contains oleic acid at the sn-1, sn-2, and sn-3 positions.
  8. GC45341 4-Amino-6-chloro-1,3-benzenedisulfonamide  
  9. GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
  10. GC41642 9(E),11(E),13(E)-Octadecatrienoic Acid 9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid.
  11. GC42665 AAF-CMK (trifluoroacetate salt) Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.
  12. GC46769 Abametapir
  13. GC46779 Acequinocyl
  14. GC16350 Actinonin Peptidomimetic antibiotic that inhibits aminopeptidases
  15. GC46820 AHU377-d4
  16. GC35300 Aloin(mixture of A&B) Aloin (mixture of A&B) 是从芦荟中分离出来的蒽醌衍生物。Aloin (mixture of A&B) 具有多种生物活性,如抗炎、免疫、抗糖尿病、抗氧化、抗菌、抗真菌和抗肿瘤活性。Aloin (mixture of A&B) 是刺激性粒细胞基质金属蛋白酶 (MMPs) 的有效抑制剂。
  17. GP10057 Amyloid β-Peptide (10-20) (human)

    Initiates neurodegeneration in Alzheimer disease

  18. GC46854 Anastrozole-d12
  19. GC35369 Apigenin-7-glucuronide Apigenin-7-glucuronide 能够抑制基质金属蛋白酶 (MMP) 的活性,其对 MMP-3,MMP-8,MMP-9,MMP-13 的IC50 值分别为 12.87,22.39,17.52,0.27 μM。
  20. GC35377 Apratastat

    Apratastat 是一种口服活性,有效且可逆的肿瘤坏死因子-α 转换酶 TACE 和基质金属蛋白酶 MMPs 的双重抑制剂。Apratastat 可以在体外,离体和体内有效抑制 TNF-α 的释放,体外和离体的 IC50 分别为 144 ng/mL和 81.7 ng/mL。

  21. GN10063 Arctigenin Anti-inflammatory, antiproliferative

Items 1 to 20 of 157 total

per page
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction