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MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

Products for  MMP

  1. Cat.No. 产品名称 Information
  2. GC15005 ONO 4817 An inhibitor of MMP-2 and MMP-9
  3. GC12157 CP 471474 A broad-spectrum MMP inhibitor
  4. GC15952 CL 82198 hydrochloride An inhibitor of MMP-13
  5. GC12465 ARP 101 ARP 101 是一种有效的选择性抑制剂基质金属蛋白酶 2 (MMP-2)。 ARP 101 在癌细胞中诱导自噬相关的细胞死亡。 ARP 101 可有效诱导自噬体的形成和 LC3I 转化为 LC3II。
  6. GC13487 ARP 100 A selective inhibitor of MMP-2
  7. GC18144 CTS-1027 An inhibitor of MMPs
  8. GC13456 Doxycycline hyclate

    A broad-spectrum tetracycline antibiotic

  9. GC14210 NSC 405020 N/A
  10. GC14523 GM 6001 A broad spectrum inhibitor of zinc-containing proteases
  11. GC14099 Marimastat A broad-spectrum inhibitor of MMPs and TACE
  12. GN10342 Chondroitin sulfate 硫酸软骨素是五类糖胺聚糖之一,已广泛用于治疗骨关节炎。
  13. GN10810 Cordycepin A nucleoside analog that inhibits polyadenylation
  14. GN10063 Arctigenin A plant lignan with antioxidant, anti-inflammatory, antiproliferative, and antiviral activity
  15. GN10783 (R) Ginsenoside Rh2 A steroid glycoside with diverse biological activities
  16. GN10473 Ginkgolide C A PAF receptor antagonist
  17. GN10211 Salvianolic acid A An antioxidant and free radical scavenger
  18. GN10494 Astragaloside IV A bioactive saponin from Astragalus
  19. GN10578 Polygalacic acid A triterpenoid saponin with antioxidant and neuroprotective activities
  20. GN10360 Morroniside A mixture of iridoid glucosides
  21. GN10359 Stigmasterol

    Stigmasterol豆甾醇是一种天然的甾醇。Stigmasterol具有显著的抗关节炎和抗炎作用。

  22. GC16530 Batimastat (BB-94) A potent broad spectrum inhibitor of MMPs
  23. GP10057 Amyloid β-Peptide (10-20) (human)

    Amyloid β-Peptide (10-20) (human) 是 Amyloid-&#946 的片段;肽,可用于神经系统疾病的研究。

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