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Home >> Signaling Pathways >> Proteases >> MMP

MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

Products for  MMP

  1. Cat.No. 产品名称 Information
  2. GC43912 Isoapoptolidin Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
  3. GC43780 GM 1489 An MMP inhibitor
  4. GC43725 Gallocyanine

    花菁

     A Dkk1 inhibitor
  5. GC43188 CAY10680 A dual inhibitor of monoamine oxidase B and adenosine A2A receptors
  6. GC43146 Caspase-9 Inhibitor III (trifluoroacetate salt)

    Ac-LEHD-CMK

     A caspase-9 inhibitor
  7. GC43114 Caffeic Acid-13C3 An internal standard for the quantification of caffeic acid
  8. GC43051 C18 L-threo Ceramide (d18:1/18:0)

    N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)

     A synthetic ceramide
  9. GC43050 C18 L-erythro Ceramide (d18:1/18:0)

    L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine

     A naturally occurring ceramide
  10. GC42873 Auraptene

    橙皮油素

     A coumarin derivative with anti-inflammatory and chemopreventative activity
  11. GC42665 AAF-CMK (trifluoroacetate salt)

    NAlaAlaPheCMK, Tripeptidyl Peptidase Inhibitor II

     An inhibitor of TPPII
  12. GC41776 Triolein (1,2,3-Trioleoyl-rac-glycerol)

    三油酸甘油酯

     Triolein (1,2,3-Trioleoyl-rac-glycerol)是一种甘油三酯，被用于研究脂质代谢相关过程。Triolein可作为模型底物来探究脂肪在体内的消化、吸收以及转运等情况。
  13. GC41642 9(E),11(E),13(E)-Octadecatrienoic Acid

    β-Eleostearic Acid, β-ESA

     A polyunsaturated fatty acid
  14. GC41552 ω-3 Arachidonic Acid

    ω3 AA

     A rare, natural 20:4 ω-3 polyunsaturated fatty acid
  15. GC41258 Spiroxamine

    螺噁茂胺

     A fungicide
  16. GC41251 Pirlindole

    坡尔吲哚

     A selective and reversible MAO-A inhibitor
  17. GC40624 MMP-3 Inhibitor VIII

    Matrix Metalloproteinase-3 Inhibitor VIII, Stromelysin-1 Inhibitor VIII

     A selective inhibitor of MMP-3
  18. GC40538 Decylubiquinone

    癸基泛醌

     An analog of ubiquinone (coenzyme Q10)
  19. GC40234 Ramipril-d5

    雷米普利 d5

     An internal standard for the quantification of ramipril
  20. GC40229 (±)-Warfarin-d5

    4-羟基-3-[3-氧代-1-(苯基-D5)丁基]-2H-1-苯并吡喃-2-酮,WARF-42-d5; Athrombine-K-d5

     An internal standard for the quantification of warfarin
  21. GC40221 Ritonavir-d6

    利托那韦 d6

     An internal standard for the quantification of ritonavir
  22. GC40220 Pravastatin-d3 (sodium salt) An internal standard for the quantification of pravastatin
  23. GC33881 Ro 31-9790 (GI4747)

    GI4747

     Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。
  24. GC33365 BR351 precursor BR351precursor是BR351的前体。BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。
  25. GC33330 Cynaropicrin

    菜蓟苦素

     A sesquiterpene lactone
  26. GC33164 PNU-248686A PNU-248686A是一种新型的基质金属蛋白酶(MMP)抑制剂。
  27. GC32951 Prinomastat (AG3340)

    普啉司他; AG3340; KB-R9896

     An inhibitor of MMP-2, -3, -9, -13, and -14
  28. GC32938 S 3304 S-3304是一个新型的基质金属蛋白酶(MMP)抑制剂,且对MMP-2和MMP-9有特异的抑制活性。
  29. GC32823 Incyclinide (CMT-3)

    CMT-3; COL-3

     An inhibitor of MMP-13, MMP-1, and MMP-8
  30. GC32792 JNJ0966 An inhibitor of MMP-9 zymogen activation
  31. GC32758 Isoginkgetin

    异银杏素

     A biflavonoid inhibitor of pre-mRNA splicing
  32. GC32505 XL-784

    XL-784是MMP的一个选择性抑制剂，其对MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别约为1900，0.81，120，10.8，18，0.56nM。
  33. GC32442 BR351 BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。
  34. GC31898 Histatin 5

    富组蛋白5

     Histatin 5可抑制基质金属蛋白酶MMP-2和MMP-9的活性，IC50值分别为0.57μM和0.25μM。
  35. GC31862 T-26c A selective inhibitor of MMP-13
  36. GC31734 S-methyl-KE-298 (M-2)

    M-2

    S-methyl-KE-298 (M-2) 是 KE-298 的活性代谢物。
  37. GC19483 MS-PPOH A potent, selective inhibitor of microsomal CYP450 epoxidase activity
  38. GC19347 TAPI-2

    TNF Protease Inhibitor 2

     An inhibitor of TACE and MMPs
  39. GC18791 Prostaglandin H1

    前列腺素H1

     The precursor to all 1-series prostaglandins and thromboxanes
  40. GC18709 D-NMMA (acetate)

    NG-单甲基-D-精氨酸醋酸盐

     A control compound for studying NOS inhibition
  41. GC18706 SR 9186

    ML368

     A selective inhibitor of CYP3A4
  42. GC18659 Ribavirin 5'-monophosphate (lithium salt)

    利巴韦林5'-单磷酸二锂盐

     A potent, broad-spectrum antiviral agent
  43. GC18616 MMP-8 Inhibitor I

    Matrix Metalloproteinase-8 Inhibitor I

     A selective inhibitor of MMP-8
  44. GC18612 MMP-9/MMP-13 Inhibitor I

    Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I

     An MMP inhibitor
  45. GC18608 MMP-2/MMP-9 Inhibitor II

    Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II

     A dual inhibitor of MMP-2 and MMP-9
  46. GC18517 Diapocynin An inhibitor of NADPH-oxidase
  47. GC18510 Siccanin

    西卡宁

     An inhibitor of mitochondrial complex II
  48. GC18359 4-Epianhydrochlortetracycline (hydrochloride)

    4-差向四环素盐酸盐

     An inhibitor of MMP-9
  49. GC16165 T-5224

    T-5224 是一种非肽类小分子 AP-1 抑制剂，特异性抑制 AP-1 与启动子区 AP-1 结合位点的结合，最初开发为抗炎药用于治疗类风湿性关节炎 (RA) 抑制炎症细胞因子和 MMPs 而没有任何副作用。
  50. GC13005 MMP-2 Inhibitor II

    ​Matrix Metalloproteinase-2 Inhibitor II

     A selective MMP-2 inhibitor
  51. GC17738 MMP-2 Inhibitor I

    ​Matrix Metalloproteinase-2 Inhibitor I,cis-9-Octadecenoyl-N-hydroxylamide,Oleylhydroxamate

     A selective MMP-2 inhibitor

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