MMP(基质金属蛋白酶)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
Products for MMP
- Cat.No. 产品名称 Information
- GC40221 Ritonavir-d6 An internal standard for the quantification of ritonavir
- GC40220 Pravastatin-d3 (sodium salt) An internal standard for the quantification of pravastatin
- GC33881 Ro 31-9790 (GI4747) Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。
- GC33365 BR351 precursor BR351precursor是BR351的前体。BR351是可渗透血脑屏障的MMP抑制剂,抑制MMP2,MMP8,MMP9,MMP13的IC50分别为4,2,11,50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。
- GC33330 Cynaropicrin A sesquiterpene lactone
- GC33164 PNU-248686A PNU-248686A是一种新型的基质金属蛋白酶(MMP)抑制剂。
- GC32951 Prinomastat (AG3340) An inhibitor of MMP-2, -3, -9, -13, and -14
- GC32938 S 3304 S-3304是一个新型的基质金属蛋白酶(MMP)抑制剂,且对MMP-2和MMP-9有特异的抑制活性。
- GC32823 Incyclinide (CMT-3) An inhibitor of MMP-13, MMP-1, and MMP-8
- GC32792 JNJ0966 An inhibitor of MMP-9 zymogen activation
- GC32758 Isoginkgetin A biflavonoid inhibitor of pre-mRNA splicing
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GC32505
XL-784
XL-784是MMP的一个选择性抑制剂,其对MMP-1,MMP-3,MMP-8,MMP-9,MMP-13的IC50值分别约为1900,0.81,120,10.8,18,0.56nM。
- GC32442 BR351 BR351是可渗透血脑屏障的MMP抑制剂,抑制MMP2,MMP8,MMP9,MMP13的IC50分别为4,2,11,50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。
- GC31898 Histatin 5 An antimicrobial peptide
- GC31862 T-26c A selective inhibitor of MMP-13
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GC31734
S-methyl-KE-298 (M-2)
S-methyl-KE-298 (M-2) 是 KE-298 的活性代谢物。
- GC19483 MS-PPOH A potent, selective inhibitor of microsomal CYP450 epoxidase activity
- GC19347 TAPI-2 An inhibitor of TACE and MMPs
- GC18791 Prostaglandin H1 The precursor to all 1-series prostaglandins and thromboxanes
- GC18709 D-NMMA (acetate) A control compound for studying NOS inhibition
- GC18706 SR 9186 A selective inhibitor of CYP3A4
- GC18659 Ribavirin 5'-monophosphate (lithium salt) A potent, broad-spectrum antiviral agent
- GC18616 MMP-8 Inhibitor I A selective inhibitor of MMP-8
- GC18612 MMP-9/MMP-13 Inhibitor I An MMP inhibitor
- GC18608 MMP-2/MMP-9 Inhibitor II A dual inhibitor of MMP-2 and MMP-9
- GC18517 Diapocynin An inhibitor of NADPH-oxidase
- GC18510 Siccanin An inhibitor of mitochondrial complex II
- GC18359 4-Epianhydrochlortetracycline (hydrochloride) An inhibitor of MMP-9
- GC16165 T-5224 An inhibitor of c-fos/AP-1
- GC13005 MMP-2 Inhibitor II A selective MMP-2 inhibitor
- GC17738 MMP-2 Inhibitor I A selective MMP-2 inhibitor
- GC11038 MMP-2/MMP-9 Inhibitor I An inhibitor of MMP-2 and MMP-9
- GC10149 cis-ACCP A matrix metalloproteinase inhibitor
- GC17245 MMP-13 Inhibitor A selective MMP-13 inhibitor
- GC11764 MMP Inhibitor II A broad-range inhibitor of MMPs
- GC16350 Actinonin An aminopeptidase inhibitor
- GC15726 NNGH A broad-spectrum MMP inhibitor
- GC17702 K-Ras(G12C) inhibitor 9 An allosteric inhibitor of oncogenic K-Ras(G12C)
- GC15206 DC_AC50 An inhibitor of Atox1 and CCS
- GC17242 (-)-epigallocatechin A green tea polyphenol
- GC16577 SB-3CT A selective inhibitor of MMP-2 and MMP-9
- GC12344 TAPI-1 A TACE inhibitor
- GC13750 Doxycycline HCl Doxycycline HCl 是一种抗生素,是一种具有口服活性的广谱金属蛋白酶 (MMP) 抑制剂。
- GC12838 Edaravone A free radical scavenger
- GC15954 UK 356618 An inhibitor of MMP-3
- GC14578 GI 254023X An ADAM10 inhibitor
- GC13707 WAY 170523 WAY 170523 是一种有效的选择性 MMP-13(基质金属蛋白酶 13)抑制剂,IC50 为 17 nM。 WAY 170523 可以直接减弱 ERK1/2 磷酸化。 WAY 170523抑制PC-3细胞的侵袭,可用于前列腺癌研究。
- GC16579 UK 370106 UK 370106 是一种有效且高度选择性的 MMP-3(IC50 为 23 nM)和 MMP-12(IC50 为 42 nM)抑制剂,其效力比 MMP-1、MMP-2、MMP-9 和 MMP 高 1200 倍以上-14,大约是 MMP-13 和 MMP-8 的 100 倍。
- GC10805 Ro 32-3555 Ro 32-3555 是一种有效的、竞争性的人类胶原酶 1、2 和 3 抑制剂,Kis 分别为 3.0、4.4 和 3.4 nM。
- GC12111 PD 166793 An broad-spectrum MMP inhibitor