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Oxamyl Sale

(Synonyms: 杀线威) 目录号 : GC47847

A carbamate pesticide

Oxamyl Chemical Structure

Cas No.:23135-22-0

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50 mg
¥770.00
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100 mg
¥1,234.00
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产品描述

Oxamyl is a carbamate pesticide and an inhibitor of acetylcholinesterase (AChE; IC50 = 1.67 μM for C. gigas enzyme).1 It is nematocidal, decreasing the number of P. penetrans and M. hapla per gram of alfalfa (M. sativa) root when applied to seeds at a concentration of 50 mg/ml.2 Oxamyl (50 and 100 μg/ml) is also toxic to citrus nematode (T. semipenetrans) larvae.3 In vivo, oxamyl (2.1 and 3.5 mg/kg) inhibits plasma and brain AChE, as well as liver glucose-6-phosphatase and succinic acid dehydrogenase, and reduces body weight gain in rats.4 Formulations containing oxamyl have been used to control nematode infestation of field crops.

1.Anguiano, G.A., Amador, A., Moreno-Legorreta, M., et al.Effects of exposure to oxamyl, carbofuran, dichlorvos, and lindane on acetylcholinesterase activity in the gills of the Pacific oyster Crassostrea gigasEnviron. Toxicol.25(4)327-332(2010) 2.Townshend, J.L., and Chiba, M.Control of Pratylenchus penetrans and Meloidogyne hapla and yield response of alfalfa due to oxamyl seed treatmentsJ. Nematol.19(4)454-458(1987) 3.Baines, R.C., and Small, R.H.Effects of oxamyl on the citrus nematode, Tylenchulus semipenetrans, and on infection of sweet orangeJ. Nematol.8(2)122-130(1976) 4.Fayez, V., and Kilgore, W.W.Acute toxic effects of oxamyl in the ratFundam. Appl. Toxicol.18(1)155-159(1992)

Chemical Properties

Cas No. 23135-22-0 SDF
别名 杀线威
Canonical SMILES CN(C)C(/C(SC)=N/OC(NC)=O)=O
分子式 C7H13N3O3S 分子量 219.3
溶解度 Chloroform: Slightly Soluble,Methanol: Slightly Soluble 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 4.56 mL 22.7998 mL 45.5996 mL
5 mM 0.912 mL 4.56 mL 9.1199 mL
10 mM 0.456 mL 2.28 mL 4.56 mL
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Research Update

Peer review of the pesticide risk assessment of the active substance Oxamyl

EFSA J 2022 May 18;20(5):e07296.PMID:35600268DOI:10.2903/j.efsa.2022.7296.

The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Italy, and co-rapporteur Member State, France, for the pesticide active substance Oxamyl and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative uses of Oxamyl as a nematicide on potato and tobacco (field use), on tomato (permanent greenhouse), on cucurbits (edible and inedible peel), pepper, aubergine and plants nurseries of the above-mentioned crops on soil bed preparation (permanent greenhouse). The reliable end points, appropriate for use in regulatory risk assessment and the proposed MRLs, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

Oxamyl exerts developmental toxic effects in zebrafish by disrupting the mitochondrial electron transport chain and modulating PI3K/Akt and p38 Mapk signaling

Sci Total Environ 2023 Feb 10;859(Pt 2):160458.PMID:36435248DOI:10.1016/j.scitotenv.2022.160458.

Oxamyl, a carbamate insecticide, is mainly used to control nematodes in the agricultural field. Although Oxamyl is a widely used insecticide that is associated with ecological concerns, limited studies have examined the toxic effects of Oxamyl on the developmental stage and the underlying mechanisms. In this study, the developmental toxicity of Oxamyl was demonstrated using zebrafish, which is a representative model as it is associated with rapid embryogenesis and a toxic response similar to that of other vertebrates. The morphological alteration of zebrafish larvae was analyzed to confirm the sub-lethal toxicity of Oxamyl. Analysis of transgenic zebrafish (olig2:dsRED and flk1:eGFP line) and mRNA levels of genes associated with individual organ development revealed that Oxamyl exerted toxic effects on the development of neuron, notochord, and vascular system. Next, the adverse effect of Oxamyl on the mitochondrial electron transport chain was examined. Treatment with Oxamyl altered the PI3K/Akt signaling and p38 Mapk signaling pathways in zebrafish. Thus, this study elucidated the mechanisms underlying the developmental toxicity of Oxamyl and provided information on the parameters to assess the developmental toxicity of other environmental contaminants.

Assessment of the effects of Oxamyl on the bacterial community of an agricultural soil exhibiting enhanced biodegradation

Sci Total Environ 2019 Feb 15;651(Pt 1):1189-1198.PMID:30360251DOI:10.1016/j.scitotenv.2018.09.255.

Modern agricultural practices largely rely on pesticides to protect crops against various pests and to ensure high yields. Following their application to crops a large amount of pesticides ends up in soil where they may affect non-target organisms, among which microorganisms. We assessed the effects of the carbamate nematicide Oxamyl on the whole bacterial diversity of an agricultural soil exhibiting enhanced biodegradation of Oxamyl through 16S rRNA amplicon next generation sequencing (NGS) and on the oxamyl-degrading bacterial community through cehA q-PCR analysis and 14C-oxamyl mineralization assays. Oxamyl was rapidly mineralized by the indigenous microorganisms reaching >70% within a month. Concomitantly, a significant increase in the number of oxamyl-degrading microorganisms was observed. NGS analysis of the total (DNA) and active (RNA) bacterial community showed no changes in α-diversity indices in response to Oxamyl exposure. Analysis of the β-diversity revealed significant changes in the composition of the soil bacterial community after 13 and 30 days of Oxamyl exposure only when the active fraction of the bacterial community was considered. These changes were associated with seven OTUs related to Proteobacteria (5), Acidobacteria (1) and Actinobacteria (1). The relative abundance of the dominant bacterial phyla were not affected by Oxamyl, except of Bacteroidetes and Gemmatimonadetes which decreased after 13 and 30 days of Oxamyl exposure respectively. To conclude, Oxamyl induced changes in the abundance of oxamyl-degrading microorganisms and on the diversity of the soil bacterial community. The latter became evident only upon RNA-based NGS analysis emphasizing the utility of such approaches when the effects of pesticides on the soil microbial community are explored.

Toxicity evaluation of Oxamyl against tomato russet mite, Aculops lycopersici (Massee) (Acari: Eriophyideae) and two spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) under greenhouse conditions

Braz J Biol 2022 Mar 14;84:e253469.PMID:35293530DOI:10.1590/1519-6984.253469.

Agriculture sector of Saudi Arabia is growing swiftly and tomato is an important crop cultivated mostly under green houses. Unfortunately, it is facing severe infestation due to divers mite species. Present study, relates to evaluation of toxicity of Oxamyl against two phytophagous mites; Aculops lycopersici and Tetranychus urticae, isolated from tomato plants suffering from infestation. Simultaneous effect of Oxamyl on two predatory mites; Neosiulus cucumeris and Euseius scutalis, was also evaluated. Three concentrations of Oxamyl; half of the recommended dose (HRD), recommended dose (RD) and double recommended dose (DRD), were used against each mite specie to observe mortality within seven days as compared to the control. Significant mortality of 97.91% and 93.92% was observed in A. lycopersici and T. urticae, respectively at RD. In case of predatory mites; N. cucumeris and E. scutalis, mortality was 60.61% and 64.48%, respectively, under same conditions. Mortality of mites observed at HRD was insignificant and there was negligible increase in mortality at DRD. Oxamyl being less toxic to predatory mites and significantly mortal to phytophagous mites is recommended as a tool to as a tool to achieve biological control parallel to pesticidal effect.

Isolation of Oxamyl-degrading Bacteria and Identification of cehA as a Novel Oxamyl Hydrolase Gene

Front Microbiol 2016 Apr 29;7:616.PMID:27199945DOI:10.3389/fmicb.2016.00616.

Microbial degradation is the main process controlling the environmental dissipation of the nematicide Oxamyl. Despite that, little is known regarding the microorganisms involved in its biotransformation. We report the isolation of four oxamyl-degrading bacterial strains from an agricultural soil exhibiting enhanced biodegradation of Oxamyl. Multilocus sequence analysis (MLSA) assigned the isolated bacteria to different subgroups of the genus Pseudomonas. The isolated bacteria hydrolyzed Oxamyl to Oxamyl oxime, which was not further transformed, and utilized methylamine as a C and N source. This was further supported by the detection of methylamine dehydrogenase in three of the four isolates. All oxamyl-degrading strains carried a gene highly homologous to a carbamate-hydrolase gene cehA previously identified in carbaryl- and carbofuran-degrading strains. Transcription analysis verified its direct involvement in the hydrolysis of Oxamyl. Selected isolates exhibited relaxed degrading specificity and transformed all carbamates tested including the oximino carbamates aldicarb and methomyl (structurally related to Oxamyl) and the aryl-methyl carbamates carbofuran and carbaryl which share with Oxamyl only the carbamate moiety.