FXR & LXR
FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.
LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.
Products for FXR & LXR
- Cat.No. 产品名称 Information
- GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂,在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。
- GC34965 (20S)-Protopanaxatriol An active ginsenoside metabolite
- GC14972 22(R)-hydroxy Cholesterol An endogenous agonist for LXRα
- GC18270 22(S)-hydroxy Cholesterol A synthetic oxysterol and LXR modulator
- GC17827 24(R)-hydroxy Cholesterol A synthetic enantiomer of a brain-derived oxysterol
- GC40571 24(S),25-epoxy Cholesterol An oxysterol
- GC18076 24(S)-hydroxy Cholesterol An agonist of LXR receptors
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GC33673
24-Hydroxycholesterol
24-Hydroxycholesterol是一种天然的固醇类物质,是n-甲基-d-天门冬氨酸受体(NMDA)和转录因子LXR的激活剂。
- GC13431 24α-methyl Cholesterol A phytosterol
- GC13887 25(R)-27-hydroxy Cholesterol An endogenous agonist for LXR
- GC11700 25(S)-27-hydroxy Cholesterol An endogenous agonist for LXR
- GC40053 5α,6α-epoxy Cholestanol An oxysterol
- GC17059 Acetyl Podocarpic Acid Anhydride An endogenous LXR agonist
- GC40024 Altenusin A fungal metabolite with diverse biological activities
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GC30842
Androsterone (5α-Androstan-3α-ol-17-one)
An androgenic steroid
- GC32801 AZ876 An LXR agonist
- GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
- GC42943 Bischloroanthrabenzoxocinone An inhibitor of FAS-II
- GC31372 BMS-779788 (EXEL04286652) An LXR agonist
- GC48426 CAY10771 A dual agonist of FXR and PPARδ
- GC17985 Chenodeoxycholic Acid A primary bile acid
- GC48424 Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide A metabolite of CDCA
- GC49853 Chenodeoxycholic Acid 3-Glucuronide A metabolite of CDCA
- GC48595 Chenodeoxycholic Acid MaxSpec® Standard A primary bile acid
- GC68212 Chenodeoxycholic acid-13C Chenodeoxycholic acid-13C (CDCA-13C) 是一种 13C 标记的 Chenodeoxycholic Acid。Chenodeoxycholic Acid 是一种疏水初级胆汁酸,能够活化核受体 FXR,该受体与胆固醇代谢有关。
- GC47076 Chenodeoxycholic Acid-d4 An internal standard for the quantification of chenodeoxycholic acid
- GC18212 Cilofexor An FXR ligand
- GC65260 EDP-305 EDP-305 是一种口服有效且选择性的 farnesoid X 受体 (FXR) 激动剂,其 EC50 值为 34 nM (CHO 细胞嵌合性 FXR) 和 8 nM (HEK 细胞全长 FXR)。EDP-305 显示出强大而持久的抗纤维化作用。EDP-305 可用于原发性胆道胆管炎 (PBC) 和非酒精性脂肪性肝炎 (NASH) 研究。
- GC10755 Fexaramine A selective FXR agonist
- GC69138 FXR agonist 5 FXR agonist 5 (compound 1) 是一种 FXR 激动剂。FXR agonist 5 可用于研究代谢性炎症引起的疾病或紊乱。
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GC40911
Glycine-β-muricholic Acid
An intestine-selective FXR antagonist
- GC45466 Glyco-Obeticholic Acid An active metabolite of obeticholic acid
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GC31331
GSK2033
An antagonist of LXRα and LXRβ
- GC48610 GSK3987 A dual agonist of LXRα and LXRβ
- GC17658 Guggulsterone Guggulsterone 是一种植物甾醇,来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物(IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin),调节细胞周期蛋白(cyclin D1 和c-Myc),激活半胱天冬酶和 JNK,抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂,可降低 CDCA 诱导的 FXR 活化,对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
- GC16964 GW3965 An orally-active agonist of LXRα and LXRβ
- GC17696 GW3965 HCl An orally-active agonist of LXRα and LXRβ
- GC10975 GW4064 A potent, selective agonist of farnesoid X receptor
- GC32742 INT-767 INT-767是法尼醇X受体/TGR5双激动剂,平均EC50分别为30和630nM。
- GC65936 Larsucosterol (trimethylamine) Larsucosterol (DUR-928) trimethylamine 是一种胆固醇代谢物,是一种有效的肝 X 受体 (LXR) 拮抗剂。Larsucosterol trimethylamine 是一种有效的内源性脂肪生成调节剂。Larsucosterol trimethylamine 通过降低 mRNA 水平和抑制 SREBP-1 的激活抑制胆固醇的生物合成。
- GC36499 LXRβ agonist-2 LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂,EC50为 7 nM,其选择性是 LXRα (EC50=200 nM) 的 28.5 倍,用于治疗动脉粥样硬化。
- GC13954 LXR-623 An LXR modulator
- GC19421 LY2562175 An FXR agonist
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GC31314
Nagilactone B
NagilactoneB,是从Podocarpusnagi根皮中提取的,是一种肝X受体(LXR)激动剂。
- GC69541 NDB NDB 是一种选择性人 FXRα (hFXRα) 拮抗剂,可有效调节 FXRα 下游基因的转录。NDB可用于抗糖尿病研究。
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GC34686
Nidufexor
An FXR partial agonist
- GC14158 Obeticholic Acid Agonist of farnesoid X receptor (FXR)
- GC31395 PX20606 trans racemate (PX-102 trans racemate) PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂,在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。
- GC19448 RGX-104 RGX-104 是一种小分子 LXR 激动剂,通过 ApoE 基因的转录激活来调节先天免疫。
- GC37525 RGX-104 free Acid RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂,通过ApoE基因的转录激活调节先天免疫。