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Theobromine-d6 Sale

(Synonyms: 可可碱-D6(二甲基-D6),3,7-Dimethylxanthine-d6) 目录号 : GC48162

An internal standard for the quantification of theobromine

Theobromine-d6 Chemical Structure

Cas No.:117490-40-1

规格 价格 库存 购买数量
500 μg
¥1,696.00
现货
1 mg
¥3,221.00
现货
5 mg
¥10,175.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities.1,2,3 It is an adenosine A1 receptor antagonist (IC50s = 200-280 μM in radioligand binding assays using rat brain membranes).2 Theobromine (150 μg/ml) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.1 It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day.3 Theobromine is toxic to dogs with an LD50 value of 250 to 500 mg/kg.4

1.Jang, Y.J., Koo, H.J., Sohn, E.-H., et al.Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathwaysFood Funct.6(7)2365-2374(2015) 2.Daly, J.W., Butts-Lamb, P., and Padgett, W.Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthinesCell. Mol. Neurobiol.3(1)69-80(1983) 3.Papadimitriou, A., Silva, K.C., Peixoto, E.B.M.I., et al.Theobromine increases NAD?/Sirt-1 activity and protects the kidney under diabetic conditionsAm. J. Physiol. Renal Physiol.308(3)F209-F225(2015) 4.Lawrence, L.P.Chocolate toxicosisThe 5-minute veterinary consult: Canine and feline(2004)

Chemical Properties

Cas No. 117490-40-1 SDF
别名 可可碱-D6(二甲基-D6),3,7-Dimethylxanthine-d6
Canonical SMILES O=C(C(N(C([2H])([2H])[2H])C=N1)=C1N2C([2H])([2H])[2H])NC2=O
分子式 C7H2D6N4O2 分子量 186.2
溶解度 DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.3706 mL 26.8528 mL 53.7057 mL
5 mM 1.0741 mL 5.3706 mL 10.7411 mL
10 mM 0.5371 mL 2.6853 mL 5.3706 mL
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