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SIH Sale

(Synonyms: 2-异丙基噻吨酮) 目录号 : GC48894

An iron chelator

SIH Chemical Structure

Cas No.:495-84-1

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50mg
¥892.00
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100mg
¥1,693.00
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250mg
¥4,022.00
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500mg
¥7,137.00
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产品描述

SIH is a lipophilic cell-permeable iron chelator.1,2 It stimulates iron release from, and inhibits iron uptake by, SK-N-MC human neuroblastoma cells when used at a concentration of 25 µM.3 SIH inhibits cumene hydroperoxide-induced membrane lipid peroxidation but not ABAP-induced formation of cytosolic peroxyl radicals in HepG2 human hepatocellular carcinoma cells (IC50s = 0.833 and >4,000 µM, respectively).1 It inhibits hydrogen peroxide-induced mitochondrial membrane depolarization in H9c2 rat cardiomyocytes (EC50 = 0.8 µM).2 SIH (1.0 mg/kg) completely prevents mortality in a rabbit model of cardiotoxicity induced by chronic administration of daunorubicin .4

1.Hofer, T., JØrgensen, T.Ø., and Olsen, R.L.Comparison of food antioxidants and iron chelators in two cellular free radical assays: Strong protection by luteolinJ. Agric. Food Chem.62(33)8402-8410(2014) 2.šim?nek, T., Boer, C., Bouwman, R.A., et al.SIH—a novel lipophilic iron chelator—protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell deathJ. Mol. Cell. Cardiol.39(2)345-354(2005) 3.Wu, Z., Palanimuthu, D., Braidy, N., et al.Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+ /NADH ratiosBr. J. Pharmacol.177(9)1967-1987(2019) 4.št?rba, M., PopelovÁ, O., šim?nek, T., et al.Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)Toxicology235(3)150-166(2007)

Chemical Properties

Cas No. 495-84-1 SDF
别名 2-异丙基噻吨酮
Canonical SMILES O=C(C1=CC=NC=C1)NN=CC2=C(O)C=CC=C2
分子式 C13H11N3O2 分子量 241.2
溶解度 DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.23 mg/ml,DMSO: 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.1459 mL 20.7297 mL 41.4594 mL
5 mM 0.8292 mL 4.1459 mL 8.2919 mL
10 mM 0.4146 mL 2.073 mL 4.1459 mL
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Research Update

Andrew SIH

Curr Biol 2021 Aug 9;31(15):R934-R936.PMID:34375592DOI:10.1016/j.cub.2021.07.001.

Interview with Andrew SIH, who studies the evolution and ecological impacts of behavior on population patterns at the University of California, Davis.

Spontaneous intracranial hypotension: review and expert opinion

Acta Neurol Belg 2020 Feb;120(1):9-18.PMID:31215003DOI:10.1007/s13760-019-01166-8.

Spontaneous intracranial hypotension (SIH) results from spinal cerebrospinal fluid (CSF) leaking. An underlying connective tissue disorder that predisposes to weakness of the dura is implicated in spontaneous spinal CSF leaks. During the last decades, a much larger number of spontaneous cases are identified and a far broader clinical SIH spectrum is recognized. Orthostatic headache is the main presentation symptom of SIH; some patients also have other manifestations, mainly cochlear-vestibular signs and symptoms. Differential diagnosis with other syndromes presenting with orthostatic headache is crucial. Brain CT, brain MR, spine MRI, and MRI myelography are the imaging modalities of first choice for SIH diagnosis. Invasive imaging techniques, such as myelography, CT myelography, and radioisotopic cisternography, are progressively being abandoned. No randomized clinical trials have assessed the treatment of SIH. In a minority of cases, SIH resolved spontaneously or with only conservative treatment. If orthostatic headache persists after conservative treatment, a lumbar epidural blood patch (EBP) without previous leak identification (so-called "blind" EBP) is a widely used initial intervention and may be repeated several times. If EBPs fail, after the CSF leak sites identification using invasive imaging techniques, other therapeutic approaches include: a targeted epidural patch, surgical reduction of dural sac volume, or direct surgical closure. The prognosis is generally good after intervention, but serious complications may occur. More research is needed to better understand SIH pathophysiology to refine imaging modalities and treatment approaches and to evaluate clinical outcomes.

Translational aspects of pharmacological research into anxiety disorders: the stress-induced hyperthermia (SIH) paradigm

Eur J Pharmacol 2008 May 13;585(2-3):407-25.PMID:18420191DOI:10.1016/j.ejphar.2008.02.097.

In anxiety research, the search for models with sufficient clinical predictive validity to support the translation of animal studies on anxiolytic drugs to clinical research is often challenging. This review describes the stress-induced hyperthermia (SIH) paradigm, a model that studies the activation of the autonomic nervous system in response to stress by measuring body temperature. The reproducible and robust SIH response, combined with ease of testing, make the SIH paradigm very suitable for drug screening. We will review the current knowledge on the neurobiology of the SIH response, discuss the role of GABA(A) and serotonin (5-HT) pharmacology, as well as how the SIH response relates to infectious fever. Furthermore, we will present novel data on the SIH response variance across different mice and their sensitivity to anxiolytic drugs. The SIH response is an autonomic stress response that can be successfully studied at the level of its physiology, pharmacology, neurobiology and genetics and possesses excellent animal-to-human translational properties.

[Stress-induced hyperalgesia (SIH) as a consequence of emotional deprivation and psychosocial traumatization in childhood : Implications for the treatment of chronic pain]

Schmerz 2016 Dec;30(6):526-536.PMID:27324753DOI:10.1007/s00482-016-0107-8.

It is now widely recognized that in many chronic pain syndromes the intensity and severity of individually perceived pain does not correlate consistently with the degree of peripheral nervous system tissue damage or with the intensity of primary afferent or spinal nociceptive neurone activity. In particular, stress and anxiety exert modulatory influences on pain depending on the nature, duration and intensity of the stressor and developmental influences on the maturation of the stress as well as the pain system. In some chronic pain syndromes, e. g. fibromyalgia, TMD or somatoform disorders, no nociceptive or neuropathic input is detectable. We summarise the studies investigating the neural substrates and neurobiological mechanisms of stress-induced hyperalgesia (SIH) in animals and humans. The review provides new perspectives and challenges for the current and future treatment of chronic pain.

A novel design of SIH/CeO2(111) van der Waals type-II heterojunction for water splitting

Phys Chem Chem Phys 2021 Feb 4;23(4):2812-2818.PMID:33470254DOI:10.1039/d0cp05238h.

Searching for economical low-dimensional materials to construct the highly efficient type-II heterojunction photocatalysts for splitting water into hydrogen is very strategic. In this study, using the first-principles calculations, we construct a novel SIH/CeO2(111) type-II heterojunction with a very small lattice mismatch of less than 1%. Based on AIMD simulation and phonon dispersion calculations, the SIH/CeO2(111) heterojunction reveals sufficient stability, and is easy to synthesize. Due to the vdW interaction between SIH and CeO2(111) components, electron and hole accumulation regions form at the heterojunction interface, which is very conducive to the separation of photoexcited electron-hole pairs. Besides, the SIH/CeO2(111) heterojunction has good visible light response, and even a strong absorption peak of up to 8.7 × 105 cm-1 in the high-energy visible region. More importantly, the SIH/CeO2(111) heterojunction exhibits good OER and HER performance because its oxidation and reduction potentials well meet the requirements of water splitting. Consequently, SIH/CeO2(111) is a potential photocatalyst for splitting water to hydrogen.