Home>>Montelukast-d6 (sodium salt)

Montelukast-d6 (sodium salt) Sale

(Synonyms: MK-476-d6) 目录号 : GC47701

A neuropeptide with diverse biological activities

Montelukast-d6 (sodium salt) Chemical Structure

规格 价格 库存 购买数量
500 μg
¥2,381.00
现货
1 mg
¥4,523.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Montelukast-d6 (sodium salt) is intended for use as an internal standard for the quantification of montelukast (sodium salt) by GC- or LC-MS. Montelukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor).1 It is selective for CysLT1 over CysLT2 receptors (IC50 = >10,000 nM in COS-7 cell membranes expressing the human receptor).2 Montelukast inhibits bronchoconstriction induced by leukotriene D4 in anesthetized guinea pigs (ED50 = 69 nmol/kg, p.o.).3 It inhibits ovalbumin-induced airway hyperresponsiveness and increases in the number of total cells and eosinophils in bronchoalveolar lavage fluid (BALF) in a mouse model of allergic asthma when administered at doses of 3 and 10 mg/kg.4 Formulations containing montelukast have been used in the treatment of asthma, allergic rhinitis, and exercise-induced bronchoconstriction.

1.Sarau, H.M., Ames, R.S., Chambers, J., et al.Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptorMol. Pharmacol.56(3)657-663(1999) 2.Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al.Characterization of the human cysteinyl leukotriene 2 receptorJ. Biol. Chem.275(39)30531-30536(2000) 3.CabrÉ, F., Carabaza, A., GarcÍa, A.M., et al.Pharmacological profile of MEN91507, a new CysLT1 receptor antagonistEur. J. Pharmacol.451(3)317-326(2002) 4.Eum, S.Y., Maghni, K., Hamid, Q., et al.Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouseAm. J. Respir. Cell Mol. Biol.28(1)25-32(2003)

Chemical Properties

Cas No. N/A SDF
别名 MK-476-d6
Canonical SMILES OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(C=CC=C1)=C1CC[C@@H](SCC2(CC2)CC([O-])=O)C3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3.[Na+]
分子式 C35H29ClD6NO3S.Na 分子量 614.2
溶解度 Water: Soluble 储存条件 Store at 4°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.6281 mL 8.1407 mL 16.2813 mL
5 mM 0.3256 mL 1.6281 mL 3.2563 mL
10 mM 0.1628 mL 0.8141 mL 1.6281 mL
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