EGFR(表皮生长因子受体)

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

Products for EGFR

Cat.No. 产品名称 Information
GC13213 WZ3146 An inhibitor of mutant EGFR
GC14259 HKI 357 An irreversible dual inhibitor of EGFR and HER2
GC15950 CGP 52411 A phthalimide with diverse biological activities
GC18030 JNJ 28871063 hydrochloride JNJ 28871063 hydrochloride 是一种具有口服活性、高选择性和 ATP 竞争性的 pan-ErbB 激酶抑制剂，对 ErbB1、ErbB2 和 ErbB4 的 IC50 值分别为 22 nM、38 nM 和 21 nM。 JNJ 28871063 hydrochloride 抑制 EGFR 和 ErbB2 中功能重要的酪氨酸残基的磷酸化。 JNJ 28871063 hydrochloride 可穿过血脑屏障，在过度表达 EGFR 和 ErbB2 的人类肿瘤异种移植模型中具有抗肿瘤活性。
GC15674 HDS 029 HDS 029 (compound 29) 是一种有效的酪氨酸激酶抑制剂，对 erbB1、erbB2、erbB4、EGF、HER 的 IC50 分别为 0.3、1.1、0.5、2.5、24 nM。
GC15925 PD 158780 An ErbB receptor family inhibitor
GC10815 BIBU 1361 dihydrochloride EGFR inhibitor
GC15927 GW 583340 dihydrochloride dual EGFR/ErbB2 tyrosine kinase inhibitor
GC13168 AG 825 An inhibitor of Her2/Neu tyrosine kinase activity
GC17489 AG 494 An inhibitor of EGF receptor kinase
GC11744 AG 555 A tyrphostin EGFR inhibitor
GC12233 AG 556 An EGFR inhibitor
GC15038 Tyrphostin B44, (+) enantiomer Tyrphostin B44, (+) enantiomer (Tyrphostin AG 835) (Compound B50) 是一种具有抗肿瘤活性的 EGRF 抑制剂。
GC12977 Tyrphostin B44, (-) enantiomer EGFR-kinase inhibitor
GC12069 Methyl 2,5-dihydroxycinnamate An EGFR tyrosine kinase inhibitor
GC14494 AG 99 An inhibitor of EGF receptor kinase
GC14136 BMS 599626 dihydrochloride EGFR and ErbB2 inhibitor,potent and selective
GC16021 Lavendustin A A selective inhibitor of EGF receptor-associated tyrosine kinase
GC15271 Tyrphostin AG 879 A non-specific tyrphostin ErbB2 inhibitor
GC10250 Mubritinib (TAK 165) A selective inhibitor of HER2
GC13854 AG-490 (Tyrphostin B42) AG-490是EGFR抑制剂,IC50为0.1 µM, AG-490对JAK2也有抑制作用。.
GC16698 AZD-9291 mesylate
An inhibitor of mutant EGFR
GC16308 AZD-9291
An inhibitor of mutant EGFR
GC17982 Icotinib An EGFR inhibitor
GC11126 Mutant EGFR inhibitor Mutant EGFR inhibitor 是从专利WO 2013014448 A1中提取的一种有效的选择性突变EGFR抑制剂；抑制 EGFRL858R、EGFRExon 19 缺失和 EGFRT790M。
GC15669 AST-1306 TsOH An irreversible inhibitor of EGFR, HER2, and HER4
GC17530 OSI-420 OSI-420 (OSI-420) 是厄洛替尼的活性代谢物。厄洛替尼是一种有效的 EGFR 酪氨酸激酶抑制剂。
GC11264 CNX-2006 An irreversible inhibitor of mutant EGFRs
GC16000 WHI-P180 A multi-kinase inhibitor
GC11172 TAK-285 A dual inhibitor of EGFR and HER2
GC13761 AZD8931 (Sapitinib) A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3
GC11691 AST-1306 An irreversible inhibitor of EGFR, HER2, and HER4
GC12478 ARRY-380 An inhibitor of EGFR
GC12249 Varlitinib (ARRY334543) An inhibitor of EGFR and HER2
GC17226 AG-1478 An inhibitor of EGF receptor kinase
GC10362 Neratinib (HKI-272) A dual inhibitor of EGFR and HER2
GC10225 Dacomitinib (PF299804, PF299) A pan-ErbB receptor tyrosine kinase inhibitor
GC17283 AP26113 A potent ALK inhibitor
GC10944 Butein A plant polyphenol
GC17647 AG-18 An inhibitor of EGF receptor kinase
GC11015 PD168393 An irreversible EGFR kinase inhibitor
GC11892 AEE788 (NVP-AEE788) An inhibitor of EGFR and VEGFR tyrosine kinases
GC12910 Canertinib (CI-1033) Canertinib (CI-1033) (CI-1033;PD-183805) 是一种有效且不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自磷酸化，IC50 为 7.4 和 9 nM。
GC13257 AC480 (BMS-599626) A dual inhibitor of EGFR and HER2
GC11250 WZ8040 An inhibitor of mutant EGFR
GC17473 Pelitinib (EKB-569) An EGFR receptor tyrosine kinase inhibitor
GC13091 CP-724714 A selective HER2/ErbB2 tyrosine kinase inhibitor
GC15494 WZ4002 A potent inhibitor of EGFR-T790M kinase activity
GC14102 Genistein An isoflavonoid phytoestrogen
GC13296 Afatinib(BIBW2992) A selective dual inhibitor of EGFR/HER2