Carbonic Anhydrase(碳酸酐酶)
Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton. Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).
Products for Carbonic Anhydrase
- Cat.No. 产品名称 Information
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GC34186
2-Aminobenzenesulfonamide (Orthanilamide)
邻氨基苯磺酰胺,Orthanilamide
2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX. -
GC49337
4-Acetamidobenzenesulfonamide
对乙酰胺基苯磺酰胺
A metabolite of asulam and sulfanilamide -
GC20095
5,7-Dihydroxy-4-methylcoumarin
NSC 5302
A synthetic coumarin with diverse biological activities -
GC11567
Acetazolamide
乙酰唑胺
An Analytical Reference Standard -
GC33491
Acetazolamide D3
乙酰唑胺 d3
AcetazolamideD3是Acetazolamide氘代化合物标准品。 -
GC65612
Acetazolamide sodium
乙酰唑胺钠
An Analytical Reference Standard - GC64734 Benzenesulphonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) ia an inhibitor of carbonic anhydrases.
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GC62864
Benzolamide
CL11366
Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂,抑制hCA I,hCA II,EcoCAγ 和 VchCAγ 的 Ki 值分别为15 nM,9 nM,94 nM 和 78 nM。Benzolamide 还抑制 CAS3,Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。 -
GC32634
Benzthiazide
苄噻嗪
Benzthiazide是一种长效的利尿剂和抗高血压剂。Benzthiazide为碳酸酐酶9(carbonicanhydrase9(CA9))的抑制剂,对CA9,CA2和CA1的Ki值分别为8.0,8.8和10nM。Benzthiazide能够抑制肿瘤细胞增殖。 -
GC10737
Brinzolamide
布林佐胺; AL-4862
A potent carbonic anhydrase inhibitor -
GC46101
Brinzolamide-d5
布林佐胺杂质,AL-4862-d5
An internal standard for the quantification of brinzolamide
- GC71502 CA/MAO-B-IN-1 CA/MAO-B-IN-1(化合物78)是人脑碳酸酐酶(CA)和单胺氧化酶-B(MAO-B)的双重抑制剂,IC50分别为8.8和7.0 nM。
- GP26134 CA1 E.Coli CA1 E
- GP26133 CA1 Human, Active CA1 Human Recombinant produced in E
- GP26135 CA8 Human, Active CA8 Human Recombinant produced in E
- GC71498 Carbonic anhydrase inhibitor 16 Carbonic anhydrase inhibitor 16(化合物1)是一种登革热蛋白酶抑制剂,对碳酸酐酶hCA I和hCA II具有抑制活性(Ki:28.5 nM,2.2 nM)。
- GC68830 Carbonic anhydrase inhibitor 2 Carbonic anhydrase inhibitor 2 (compound 7c) 是一种碳酸酐酶 II (carbonic anhydrase II) 抑制剂,可降低青光眼兔的眼压。
- GP26141 CTSE Mouse CTSE Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 385 amino acids ( 21-397 a
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GC17454
Dichlorphenamide
二氯苯二磺胺; Diclofenamide
A carbonic anhydrase inhibitor -
GC47210
Dichlorphenamide-13C6
Diclofenamide-13C6
An internal standard for the quantification of dichlorphenamide -
GN10531
Dimethylfraxetin
二甲基白蜡树亭,6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether
A coumarin with anti-inflammatory activity -
GC13932
Dorzolamide
多佐胺; L671152; MK507
An Analytical Reference Standard -
GC17748
Dorzolamide HCl
盐酸多佐胺; L671152 hydrochloride; MK507 hydrochloride
A carbonic anhydrase inhibitor -
GC47267
Dorzolamide-d5 (hydrochloride)
L-671,152-d5, MK-507-d5
A neuropeptide with diverse biological activities -
GC31710
Ethoxzolamide (Redupresin)
乙氧苯噻唑胺,Redupresin; L-643786; PNU-4191
Ethoxzolamide (Redupresin) 是一种碳酸酐酶抑制剂,Ki 为 1 nM。 -
GC12992
Fluorometholone Acetate
氟米龙醋酸酯
A synthetic glucocorticoid -
GC47385
Furosemide-d5
呋塞米 D5
An internal standard for the quantification of furosemide -
GC66360
Girentuximab
G250; cG250
Girentuximab (G250) 是一种嵌合单克隆抗体,可与碳酸酐酶 IX (CAIX) 结合,碳酸酐酶 IX 是一种在透明细胞肾细胞癌 (ccRCC) 中广泛表达的细胞表面糖蛋白。 -
GC39792
Halazone
哈拉宗
Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water. - GC66029 hCAI/II-IN-6 hCAI/II-IN-6 是一种具有口服活性的 human carbonic anhydrase (CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII,对 hCA I,hCA II,hCA VII 和 hCA XII 的 Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。
- GC69209 hCAII-IN-8 hCAII-IN-8 是一种酰胺,是一种高选择性碳酸酐酶 (CA) 抑制剂,对 hCA II 的 IC50 值为 0.18 μM。
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GC43874
Hydroflumethiazide
氢氟噻嗪,Methforylthiazidine; Rontyl
A thiazide diuretic -
GC47441
Hydroflumethiazide-13C-d2
Methforylthiazidine-13C,d2; Rontyl-13C,d2
An internal standard for the quantification of hydroflumethiazide - GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide
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GC65549
Indisulam
N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺,E 7070
A sulfonamide with anticancer activity -
GC14226
Methazolamide
醋甲唑胺; L584601
A carbonic anhydrase inhibitor -
GC48889
Methazolamide-d6
L584601-d6
An internal standard for the quantification of methazolamide -
GC14046
Methyclothiazide
甲氯噻嗪
A thiazide diuretic -
GC49194
Metolazone-d7
SR-720-22-d7
An internal standard for the quantification of metolazone -
GC49210
N-desethyl Brinzolamide (oxalate)
AL 8520
An active metabolite of brinzolamide -
GC91667
NSC 44625
Bendroflumethiazide Impurity A,2,4-Disulfamyl-5-trifluoromethylaniline
NSC 44625 is an inhibitor of carbonic anhydrase II (CAII; Ki = 63 nM for the human enzyme). - GC49211 O-desmethyl Brinzolamide (hydrochloride) An active metabolite of brinzolamide
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GC91296
p-Carboxyphenyl Sulfate
Benzoic Acid-4-sulfate, 4-Carboxyphenyl Sulfate, para-Carboxyphenyl Sulfate, 4-Hydroxybenzoic Acid Sulfate, p-Hydroxybenzoic Acid Sulfate, para-Hydroxybenzoic Acid Sulfate
一种硫酸化的酚酸。
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GC18271
Polmacoxib
帕马考昔,CG100649
An inhibitor of COX-2 and carbonic anhydrase -
GC48895
Rufinamide-15N-d2
[15N,2H2]-卢非酰胺
An internal standard for the quantification of rufinamide -
GC30899
Sultiame
舒噻嗪
A pan-CA inhibitor and an anticonvulsant
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GC15158
Tioxolone
噻克索酮
A carbonic anhydrase I inhibitor -
GC16149
Topiramate
托吡酯; McN 4853; RWJ 17021
An anticonvulsant -
GC50198
Topiramate - d12
托吡酯-D12,McN 4853 D12 ; RWJ 17021 D12
An internal standard for the quantification of topiramate -
GC17378
U-104
SLC-0111
A carbonic anhydrase inhibitor