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Carbonic Anhydrase(碳酸酐酶)

Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton.  Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).

  1. Cat.No. 产品名称 Information
  2. GC34186 2-Aminobenzenesulfonamide (Orthanilamide) 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
  3. GC49337 4-Acetamidobenzenesulfonamide A metabolite of asulam and sulfanilamide
  4. GC11567 Acetazolamide An Analytical Reference Standard
  5. GC33491 Acetazolamide D3 AcetazolamideD3是Acetazolamide氘代化合物标准品。
  6. GC65612 Acetazolamide sodium An Analytical Reference Standard
  7. GC64734 Benzenesulphonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) ia an inhibitor of carbonic anhydrases.
  8. GC62864 Benzolamide Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂,抑制hCA I,hCA II,EcoCAγ 和 VchCAγ 的 Ki 值分别为15 nM,9 nM,94 nM 和 78 nM。Benzolamide 还抑制 CAS3,Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。
  9. GC32634 Benzthiazide Benzthiazide是一种长效的利尿剂和抗高血压剂。Benzthiazide为碳酸酐酶9(carbonicanhydrase9(CA9))的抑制剂,对CA9,CA2和CA1的Ki值分别为8.0,8.8和10nM。Benzthiazide能够抑制肿瘤细胞增殖。
  10. GC10737 Brinzolamide A potent carbonic anhydrase inhibitor
  11. GC46101 Brinzolamide-d5 An internal standard for the quantification of brinzolamide
  12. GP26134 CA1 E.Coli CA1 E
  13. GP26133 CA1 Human, Active CA1 Human Recombinant produced in E
  14. GP26135 CA8 Human, Active CA8 Human Recombinant produced in E
  15. GC68830 Carbonic anhydrase inhibitor 2 Carbonic anhydrase inhibitor 2 (compound 7c) 是一种碳酸酐酶 II (carbonic anhydrase II) 抑制剂,可降低青光眼兔的眼压。
  16. GP26141 CTSE Mouse CTSE Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 385 amino acids ( 21-397 a
  17. GC17454 Dichlorphenamide A carbonic anhydrase inhibitor
  18. GC47210 Dichlorphenamide-13C6 An internal standard for the quantification of dichlorphenamide
  19. GN10531 Dimethylfraxetin A coumarin with anti-inflammatory activity
  20. GC13932 Dorzolamide An Analytical Reference Standard
  21. GC17748 Dorzolamide HCl A carbonic anhydrase inhibitor
  22. GC31710 Ethoxzolamide (Redupresin) Ethoxzolamide (Redupresin) 是一种碳酸酐酶抑制剂,Ki 为 1 nM。
  23. GC12992 Fluorometholone Acetate A synthetic glucocorticoid
  24. GC47385 Furosemide-d5 An internal standard for the quantification of furosemide
  25. GC66360 Girentuximab Girentuximab (G250) 是一种嵌合单克隆抗体,可与碳酸酐酶 IX (CAIX) 结合,碳酸酐酶 IX 是一种在透明细胞肾细胞癌 (ccRCC) 中广泛表达的细胞表面糖蛋白。
  26. GC39792 Halazone Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water.
  27. GC66029 hCAI/II-IN-6 hCAI/II-IN-6 是一种具有口服活性的 human carbonic anhydrase (CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII,对 hCA I,hCA II,hCA VII 和 hCA XII 的 Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。
  28. GC69209 hCAII-IN-8 hCAII-IN-8 是一种酰胺,是一种高选择性碳酸酐酶 (CA) 抑制剂,对 hCA II 的 IC50 值为 0.18 μM。
  29. GC43874 Hydroflumethiazide A thiazide diuretic
  30. GC47441 Hydroflumethiazide-13C-d2 An internal standard for the quantification of hydroflumethiazide
  31. GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide
  32. GC65549 Indisulam A sulfonamide with anticancer activity
  33. GC14226 Methazolamide A carbonic anhydrase inhibitor
  34. GC48889 Methazolamide-d6 An internal standard for the quantification of methazolamide
  35. GC14046 Methyclothiazide A thiazide diuretic
  36. GC49194 Metolazone-d7 An internal standard for the quantification of metolazone
  37. GC49210 N-desethyl Brinzolamide (oxalate) An active metabolite of brinzolamide
  38. GC49211 O-desmethyl Brinzolamide (hydrochloride) An active metabolite of brinzolamide
  39. GC18271 Polmacoxib An inhibitor of COX-2 and carbonic anhydrase
  40. GC48895 Rufinamide-15N-d2 An internal standard for the quantification of rufinamide
  41. GC30899 Sultiame

    A pan-CA inhibitor and an anticonvulsant

  42. GC15158 Tioxolone A carbonic anhydrase I inhibitor
  43. GC16149 Topiramate An anticonvulsant
  44. GC50198 Topiramate - d12 An internal standard for the quantification of topiramate
  45. GC17378 U-104 A carbonic anhydrase inhibitor
  46. GC45802 Zonisamide-13C2,15N An internal standard for the quantification of zonisamide

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