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Palmitoleoyl 3-carbacyclic Phosphatidic Acid Sale

(Synonyms: 3carbacyclic PA, 3ccPA 16:1) 目录号 : GC44545

Inhibitor of autotaxin

Palmitoleoyl 3-carbacyclic Phosphatidic Acid Chemical Structure

Cas No.:910228-13-6

规格 价格 库存 购买数量
500μg
¥1,044.00
现货
1mg
¥1,987.00
现货
5mg
¥8,361.00
现货
10mg
¥14,629.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce lysophosphatidic acid (LPA). Palmitoleoyl 3-carbacyclic phosphatidic acid (3-ccPA 16:1) is a cyclic LPA analog that contains the 16:1 fatty acid, palmitoleate, at the sn-1 position of the glycerol backbone. At 25 μM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (86.9%) or LPA (99.9%) without affecting proliferation. 3-ccPA 16:1 significantly inhibits autotaxin (IC50 = 620 nM), an enzyme that is important in cancer cell survival, growth, migration, invasion and metastasis. When delivered intraperitoneally, 3-ccPA 16:1 significantly reduces the number of lung metastases formed in mice injected with B16F10 melanoma cells in the tail vein.

Chemical Properties

Cas No. 910228-13-6 SDF
别名 3carbacyclic PA, 3ccPA 16:1
Canonical SMILES CCCCCC/C=C\CCCCCCCC(=O)OCC1CCP(=O)(O)O1
分子式 C20H37O5P 分子量 388.5
溶解度 PBS (pH 7.2): 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.574 mL 12.87 mL 25.74 mL
5 mM 0.5148 mL 2.574 mL 5.148 mL
10 mM 0.2574 mL 1.287 mL 2.574 mL
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