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p-Hydroxyphenethyl trans-ferulate Sale

目录号 : GC65271

p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 (酵母α-葡萄糖苷酶,IC50 19.24 ± 1.73 µmol L-1),抗氧化,抗炎活性。p-Hydroxyphenethyl trans-ferulate 具有抗癌活性和血清素能活性。

p-Hydroxyphenethyl trans-ferulate Chemical Structure

Cas No.:84873-15-4

规格 价格 库存 购买数量
1mg
¥1,142.00
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5mg
¥2,475.00
现货
10mg
¥3,960.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic(yeast α-glucosidase,IC50 19.24 ± 1.73 µmol L-1), antioxidant, and anti-inflammatory activities[1]. p-Hydroxyphenethyl trans-ferulate shows inhibiting cancer preve

[1]. Arciniegas A ,et al. Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia[J]. QuÍmica Nova, 2017, 40(2).
[2]. Park H Y , et al. Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity[J]. Journal of the Korean Society for Applied Biological Chemistry, 2011, 54(2):194-199.

Chemical Properties

Cas No. 84873-15-4 SDF Download SDF
分子式 C18H18O5 分子量 314.33
溶解度 DMSO : 100 mg/mL (318.14 mM; Need ultrasonic) 储存条件 4°C, away from moisture and light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1814 mL 15.9068 mL 31.8137 mL
5 mM 0.6363 mL 3.1814 mL 6.3627 mL
10 mM 0.3181 mL 1.5907 mL 3.1814 mL
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Research Update

Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds

Phytochemistry 2022 Oct;202:113300.PMID:35798090DOI:10.1016/j.phytochem.2022.113300.

Thirty-three natural products were isolated from the aerial parts of Antidesma bunius, Euphorbiaceae, a plant used in Vietnamese traditional medicine against rheumatoid arthritis. All compounds were reported the first time for this species, and nine constituents resembled undescribed natural products, noticeably three coumarinolignans with 2,2-dimethyl-1,3-dioxolane moiety, two cyclopeptides, and two furofuran-type lignans connected with a phenylpropanoid moiety. The individual structures were elucidated by combining NMR and MS data, and their configuration was established by NOESY and ECD experiments and NMR calculations. Compounds with sufficient amount were analyzed for their inhibition of advanced glycation endproducts (AGEs) formation, metabolites involved in many diseases like Alzheimer, joint diseases or diabetes. With IC50 values below 0.2 mM rutin and p-Hydroxyphenethyl trans-ferulate showed to be moderately active, both still being 10-times more active than the positive control aminoguanidine.

Isolation and identification of phase II enzyme-inducing agents from nonpolar extracts of green onion (Allium spp.)

J Agric Food Chem 2006 Nov 1;54(22):8417-24.PMID:17061815DOI:10.1021/jf061582s.

The objective of the study was to isolate and identify potential cancer preventive constituents from green onion based on the ability to induce quinone reductase (QR, a representative phase II enzyme) in murine hepatoma cells (Hepa 1c1c7). Crude nonpolar solvent extracts were prepared from freeze-dried green onion by sequential refluxing with hexane and then ethyl acetate, followed by liquid-liquid extraction. Active fractions were subjected to the Hepa 1c1c7 bioassay-guided steps of flash chromatography, thin layer chromatography (TLC), and high-pressure preparative liquid chromatography (HPLC) to afford pure isolates capable of inducing QR. Multiple fractions were active in inducing QR. Five pure compounds were isolated from active fractions and identified using spectroscopic methods; these were p-Hydroxyphenethyl trans-ferulate (1), 5,6-dimethyl-2-pyridinecarboxylic acid (2), ferulic acid (3), 1-(6-hydroxy-[3]pyridyl)-propan-1-one (4), and N-trans-feruloyl 3-O-methyldopamine (5). p-Hydroxyphenethyl trans-ferulate (1) doubled QR specific activity in Hepa 1c1c7 cells at a level of 2.1 microg/mL (6.6 microM).

Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis

J Nat Prod 2006 Apr;69(4):536-41.PMID:16643021DOI:10.1021/np050301s.

Serotonin receptor (5-HT(7)) binding assay-directed fractionation of a methanol extract of the dried roots of Angelica sinensis led to the isolation and identification of 21 compounds including a new phenolic ester, angeliferulate (1), and three new phthalides, 10-angeloylbutylphthalide (2), sinaspirolide (3), and ansaspirolide (4), along with 17 known compounds, p-Hydroxyphenethyl trans-ferulate (5), Z-ligustilide (6), Z-butylidenephthalide (7), senkyunolide I (8), Z-6-hydroxy-7-methoxydihydroligustilide (9), N-butylbenzenesulfonamide (10), 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate (11), (3R,8S)-falcarindiol (12), heptadeca-1-en-9,10-epoxy-4,6-diyne-3,8-diol (13), oplopandiol (14), 8-hydroxy-1-methoxy-, Z-9-heptadecene-4,6-diyn-3-one (15), imperatorin, ferulic acid, vanillin, stigmasterol, sucrose, and 1,3-dilinolenin. This is the first report of a sulfonamide (10) identified from a higher plant source, although its presence needs further investigation. Biosynthetic pathways for dimeric phthalides 3 and 4 are proposed. Compounds 5, 7, 11, 12, 15, and imperatorin exhibited affinity toward 5-HT(7) receptors in a competitive binding assay.

Highly oxygenated triterpenes from the roots of Atropa acuminata

Nat Prod Lett 2002 Dec;16(6):371-6.PMID:12462340DOI:10.1080/10575630290033097.

Two new oleanane triterpenes; 2alpha,3alpha,24-trihydroxyolean-12-ene-28,30-dioic acid ([structure: see text]) and 2alpha,3alpha,24,28-tetrahydroxyolean-12-ene ([structure: see text]) have been isolated from the roots of Atropa acuminata. Anti-oxidant p-Hydroxyphenethyl trans-ferulate ([structure: see text]), beta-sitosterol-3-O-beta-D-glucopyranoside ([structure: see text]) and oleanolic acid ([structure: see text]) have also been reported for the first time from this species. The structures were determined by spectroscopic studies including 2D-NMR.