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Home >> Signaling Pathways >> Others >> Glucosidase

Glucosidase(葡萄糖苷酶)

Glucosidases are glycoside hydrolase enzymes.

α-glucosidase is a glucosidase located in the brush border of the small intestine that acts upon α(1→4) bonds. α-Glucosidase inhibitor is a new type of antidiabetics. By reducing the postprandial blood sugar concentration, it can effectively control the blood sugar levels, thereby reducing the occurrence of diabetic complications.

β-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in β-D-glucosides and oligosaccharides, with release of glucose. β-Glucosidase has attracted substantial attention in the scientific community because of its pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. β-glucosidases catalyze the final step of cellulose hydrolysis and are essential in cellulose degradation.

  1. Cat.No. 产品名称 Information
  2. GC70181 α-Glucosidase-IN-22 α-Glucosidase-IN-22 (compound 7i) 是一种苯并咪唑，一种有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂，IC50 为 0.64 μM。α-Glucosidase-IN-22 是一种有效的抗糖尿病活性分子，具有用于 2 型糖尿病 (T2DM) 研究的潜力。
  3. GC62551 β-Hydroxypropiovanillone β-Hydroxypropiovanillone 是一种天然化合物，对 α-葡萄糖苷酶 (α-glucosidase) 具有明显的浓度依赖性抑制作用 (IC50=257.8 μg/mL)。
  4. GC39795 (+)-Afzelechin (+)-Afzelechin 是从佛手根的根茎中分离出来的，是一种 α-葡萄糖苷酶 (alpha-glucosidase) 活性抑制剂，ID50 值为 0.13 mM。(+)-Afzelechin 可以延迟食物中碳水化合物的吸收，从而抑制餐后高血糖和高胰岛素血症。
  5. GC68525 (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 是一种可从 Rubus ellipticus var. obcordatus 中分离得到的皂苷。(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 抑制 α-Glucosidase，其 IC50 为 1.68 mM。
  6. GN10317 1-Deoxynojirimycin An iminosugar with diverse biological activities
  7. GC41992 1-Deoxynojirimycin (hydrochloride) An iminosugar with diverse biological activities
  8. GC30277 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
  9. GC35553 Brevifolincarboxylic acid A phenol with anticancer and anti-inflammatory activities
  10. GC39233 Butyl isobutyl phthalate Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
  11. GC38279 Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
  12. GC31580 Cefetrizole Ceftezole是一种α-Glucosidase抑制剂，其IC50和Ki值分别为2.1μM和0.578μM。
  13. GC32191 Celgosivir (MBI 3253) Celgosivir (MBI 3253) (MBI 3253; MDL 28574; MX3253) 是一种 α-葡萄糖苷酶 I 抑制剂；体外试验中抑制牛病毒性腹泻病毒 (BVDV)，IC50 为 1.27 μM。
  14. GC32074 Celgosivir hydrochloride (MBI 3253 (hydrochloride)) Celgosivir hydrochloride (MBI 3253 (hydrochloride)) (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) 是一种 α-葡萄糖苷酶 I 抑制剂；体外试验中抑制牛病毒性腹泻病毒 (BVDV)，IC50 为 1.27 μM。
  15. GC60706 Chrysophanol triglucoside Chrysophanoltriglucoside是一种从决明子中分离出的蒽醌类化合物，可抑制蛋白酪氨酸磷酸酶1B(PTP1B)和α-glucosidase，IC50值分别为80.17和197.06µM。Chrysophanoltriglucoside具有糖尿病研究的潜力。
  16. GC18058 Conduritol B epoxide An irreversible inhibitor of glucocerebrosidase
  17. GC60802 Eleutherol Eleutherol是从E.americana中分离得到的萘类化合物，具有抗真菌(antifungal)活性。Eleutherol抑制白假丝酵母菌，白色念珠菌，酿酒酵母和新型隐球菌的MIC值在7.8-250µg/mL之间。Eleutherol具有α-葡萄糖苷酶(α-glucosidase)抑制活性，IC50>1.00mM。
  18. GC62984 Ganoderic acid Y Ganoderic acid Y 是一种 α-葡萄糖苷酶 (α-glucosidase) 抑制剂，对酵母 α-葡萄糖苷酶的 IC50 为170 μM。Ganoderic acid Y 通过阻止肠道病毒 71 (EV71) 的脱膜而抑制其复制。
  19. GC64202 Ganoderlactone D Ganoderlactone D 对酵母中的α-葡萄糖苷酶有抑制活性，IC50 为 41.7 μM。
  20. GC69155 Gcase activator 2 Gcase activator 2 (compound 14) 是一种吡咯 [2,3-b] 吡嗪，也是一种 β-葡萄糖脑苷酶 ( Gcase ) 激活剂(EC50=3.8 μM)。Gcase activator 2 诱导 Gcase 二聚化 (包括 k 型和 v 型)。Gcase activator 2 在人和小鼠中具有较低的代谢清除率。
  21. GC38046 Gitogenin A sapogenin with enzyme inhibitory and hormone-releasing activities
  22. GC36165 Glycyrrhisoflavone Glycyrrhisoflavone，一种活性异戊二烯类黄酮化合物，主要来源于 Glycyrrhiza uralensis Fisch. 的根部提取物。Glycyrrhisoflavone 抑制 α-葡萄糖苷酶 (α-glucosidase)。
  23. GC36347 Isotanshinone I Isotanshinone I 能够抑制α-葡萄糖苷酶 (α-glucosidase) 和糖基化终产物 (AGE)，其对 α-glucosidase 和 AGE 的 IC50 值分别为 1.13, 0.432 μM。
  24. GC36375 Kaempferol 3-O-gentiobioside Kaempferol 3-O-gentiobioside 是一种从 C. alata 叶中分离得到的黄酮类化合物，具有抗糖尿病活性。Kaempferol 3-O-gentiobioside 有抗 α-glucosidase 活性，并具有对碳水化合物酶的抑制作用，其 IC50 值为 50.0 ?M。
  25. GC64519 Kaempferol-3,7-di-O-β-glucoside Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种黄酮醇，对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有酶抑制作用。Kaempferol-3,7-di-O-β-glucoside 保护分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 具有用于研究阿尔茨海默氏症的潜力。
  26. GC61635 Kaempferol-7-O-rhamnoside Kaempferol-7-O-rhamnoside是从ChimonanthusnitensOliv叶子中分离的，一种有效的α-葡萄糖苷酶活性抑制剂。Kaempferol-7-O-rhamnoside有用于糖尿病的潜力。
  27. GN10551 Licochalcone C Licochalcone C 可以抑制 α-葡萄糖苷酶，对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B (PTP1B) 的 IC50 值分别为 <100 nM 和 92.43 μM。
  28. GC64507 ML198 ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
  29. GC63442 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
  30. GC30637 N-Methylmoranoline (MOR 14)

    An inhibitor of glycoprotein processing and α-glucosidases
  31. GC61697 Naringinase Naringinase是一种水解酶复合物，具有α-L-鼠李糖苷酶和β-D-葡萄糖苷酶的活性。Naringinase在自然界中广泛存在。Naringinase可用于类固醇，抗生素的生物转化，主要用于糖苷的水解。
  32. GC63099 NCGC00092410 NCGC00092410 是一种有效，选择性和非糖性葡萄糖脑苷脂酶 (glucocerebrosidase, GC) 抑制剂，IC50 值为 31 nM。NCGC00092410 对相关水解酶没有活性。NCGC00092410 是一种 GC 分子伴侣，可提高突变型细胞株中葡萄糖脑苷脂酶的活性和溶酶体定位。NCGC00092410可用于戈谢病的研究。
  33. GC67983 Norathyriol Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase )，IC50 为 3.12 μM。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ，IC50 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。
  34. GN10114 Oroxin A A flavonoid glycoside
  35. GC65271 p-Hydroxyphenethyl trans-ferulate p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 （酵母α-葡萄糖苷酶，IC50 19.24 ± 1.73 µmol L-1），抗氧化，抗炎活性。p-Hydroxyphenethyl trans-ferulate 具有抗癌活性和血清素能活性。
  36. GC38995 Panasenoside Panasenoside 是一种从 Lilium pumilum D. C 分离的类黄酮。 Panasenoside 具有 α-葡萄糖苷酶 (α-glucosidase) 抑制活性。
  37. GN10011 Rebaudioside A A natural non-caloric sweetener
  38. GC61242 Resveratroloside Resveratroloside是一种α-glucosidase的竞争新抑制剂，能调节血糖水平。Resveratroloside具有心脏保护作用。
  39. GC34835 Terphenyllin

    A fungal metabolite with antibacterial properties
  40. GC18007 Voglibose An α-glucosidase inhibitor

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