Glucosidase(葡萄糖苷酶)
Glucosidases are glycoside hydrolase enzymes.
α-glucosidase is a glucosidase located in the brush border of the small intestine that acts upon α(1→4) bonds. α-Glucosidase inhibitor is a new type of antidiabetics. By reducing the postprandial blood sugar concentration, it can effectively control the blood sugar levels, thereby reducing the occurrence of diabetic complications.
β-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in β-D-glucosides and oligosaccharides, with release of glucose. β-Glucosidase has attracted substantial attention in the scientific community because of its pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. β-glucosidases catalyze the final step of cellulose hydrolysis and are essential in cellulose degradation.
- Cat.No. 产品名称 Information
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GC70181
α-Glucosidase-IN-22
α-Glucosidase-IN-22 (compound 7i) 是一种苯并咪唑,一种有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂,IC50 为 0.64 μM。α-Glucosidase-IN-22 是一种有效的抗糖尿病活性分子,具有用于 2 型糖尿病 (T2DM) 研究的潜力。
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GC62551
β-Hydroxypropiovanillone
β-Hydroxypropiovanillone 是一种天然化合物,对 α-葡萄糖苷酶 (α-glucosidase) 具有明显的浓度依赖性抑制作用 (IC50=257.8 μg/mL)。
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GC39795
(+)-Afzelechin
(+)-Afzelechin 是从佛手根的根茎中分离出来的,是一种 α-葡萄糖苷酶 (alpha-glucosidase) 活性抑制剂,ID50 值为 0.13 mM。(+)-Afzelechin 可以延迟食物中碳水化合物的吸收,从而抑制餐后高血糖和高胰岛素血症。
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GC68525
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid
(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 是一种可从 Rubus ellipticus var. obcordatus 中分离得到的皂苷。(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 抑制 α-Glucosidase,其 IC50 为 1.68 mM。
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GN10317
1-Deoxynojirimycin
An iminosugar with diverse biological activities
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GC41992
1-Deoxynojirimycin (hydrochloride)
An iminosugar with diverse biological activities
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GC30277
4',5-Dihydroxyflavone
4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
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GC35553
Brevifolincarboxylic acid
A phenol with anticancer and anti-inflammatory activities
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GC39233
Butyl isobutyl phthalate
Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
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GC38279
Cedryl acetate
Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
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GC31580
Cefetrizole
Ceftezole是一种α-Glucosidase抑制剂,其IC50和Ki值分别为2.1μM和0.578μM。
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GC32191
Celgosivir (MBI 3253)
Celgosivir (MBI 3253) (MBI 3253; MDL 28574; MX3253) 是一种 α-葡萄糖苷酶 I 抑制剂;体外试验中抑制牛病毒性腹泻病毒 (BVDV),IC50 为 1.27 μM。
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GC32074
Celgosivir hydrochloride (MBI 3253 (hydrochloride))
Celgosivir hydrochloride (MBI 3253 (hydrochloride)) (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) 是一种 α-葡萄糖苷酶 I 抑制剂;体外试验中抑制牛病毒性腹泻病毒 (BVDV),IC50 为 1.27 μM。
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GC60706
Chrysophanol triglucoside
Chrysophanoltriglucoside是一种从决明子中分离出的蒽醌类化合物,可抑制蛋白酪氨酸磷酸酶1B(PTP1B)和α-glucosidase,IC50值分别为80.17和197.06µM。Chrysophanoltriglucoside具有糖尿病研究的潜力。
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GC18058
Conduritol B epoxide
An irreversible inhibitor of glucocerebrosidase
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GC60802
Eleutherol
Eleutherol是从E.americana中分离得到的萘类化合物,具有抗真菌(antifungal)活性。Eleutherol抑制白假丝酵母菌,白色念珠菌,酿酒酵母和新型隐球菌的MIC值在7.8-250µg/mL之间。Eleutherol具有α-葡萄糖苷酶(α-glucosidase)抑制活性,IC50>1.00mM。
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GC62984
Ganoderic acid Y
Ganoderic acid Y 是一种 α-葡萄糖苷酶 (α-glucosidase) 抑制剂,对酵母 α-葡萄糖苷酶的 IC50 为170 μM。Ganoderic acid Y 通过阻止肠道病毒 71 (EV71) 的脱膜而抑制其复制。
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GC64202
Ganoderlactone D
Ganoderlactone D 对酵母中的α-葡萄糖苷酶有抑制活性,IC50 为 41.7 μM。
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GC69155
Gcase activator 2
Gcase activator 2 (compound 14) 是一种吡咯 [2,3-b] 吡嗪,也是一种 β-葡萄糖脑苷酶 ( Gcase ) 激活剂(EC50=3.8 μM)。Gcase activator 2 诱导 Gcase 二聚化 (包括 k 型和 v 型)。Gcase activator 2 在人和小鼠中具有较低的代谢清除率。
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GC38046
Gitogenin
A sapogenin with enzyme inhibitory and hormone-releasing activities
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GC36165
Glycyrrhisoflavone
Glycyrrhisoflavone,一种活性异戊二烯类黄酮化合物,主要来源于 Glycyrrhiza uralensis Fisch. 的根部提取物。Glycyrrhisoflavone 抑制 α-葡萄糖苷酶 (α-glucosidase)。
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GC36347
Isotanshinone I
Isotanshinone I 能够抑制α-葡萄糖苷酶 (α-glucosidase) 和糖基化终产物 (AGE),其对 α-glucosidase 和 AGE 的 IC50 值分别为 1.13, 0.432 μM。
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GC36375
Kaempferol 3-O-gentiobioside
Kaempferol 3-O-gentiobioside 是一种从 C. alata 叶中分离得到的黄酮类化合物,具有抗糖尿病活性。Kaempferol 3-O-gentiobioside 有抗 α-glucosidase 活性,并具有对碳水化合物酶的抑制作用,其 IC50 值为 50.0 ?M。
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GC64519
Kaempferol-3,7-di-O-β-glucoside
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种黄酮醇,对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有酶抑制作用。Kaempferol-3,7-di-O-β-glucoside 保护分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 具有用于研究阿尔茨海默氏症的潜力。
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GC61635
Kaempferol-7-O-rhamnoside
Kaempferol-7-O-rhamnoside是从ChimonanthusnitensOliv叶子中分离的,一种有效的α-葡萄糖苷酶活性抑制剂。Kaempferol-7-O-rhamnoside有用于糖尿病的潜力。
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GN10551
Licochalcone C
Licochalcone C 可以抑制 α-葡萄糖苷酶,对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B (PTP1B) 的 IC50 值分别为 <100 nM 和 92.43 μM。
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GC64507
ML198
ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
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GC63442
N-Caffeoyl O-methyltyramine
N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
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GC30637
N-Methylmoranoline (MOR 14)
An inhibitor of glycoprotein processing and α-glucosidases
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GC61697
Naringinase
Naringinase是一种水解酶复合物,具有α-L-鼠李糖苷酶和β-D-葡萄糖苷酶的活性。Naringinase在自然界中广泛存在。Naringinase可用于类固醇,抗生素的生物转化,主要用于糖苷的水解。
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GC63099
NCGC00092410
NCGC00092410 是一种有效,选择性和非糖性葡萄糖脑苷脂酶 (glucocerebrosidase, GC) 抑制剂,IC50 值为 31 nM。NCGC00092410 对相关水解酶没有活性。NCGC00092410 是一种 GC 分子伴侣,可提高突变型细胞株中葡萄糖脑苷脂酶的活性和溶酶体定位。NCGC00092410可用于戈谢病的研究。
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GC67983
Norathyriol
Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase ),IC50 为 3.12 μM。Norathyriol 还抑制 PPARα、PPARβ 和 PPARγ,IC50 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。
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GN10114
Oroxin A
A flavonoid glycoside
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GC65271
p-Hydroxyphenethyl trans-ferulate
p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 (酵母α-葡萄糖苷酶,IC50 19.24 ± 1.73 µmol L-1),抗氧化,抗炎活性。p-Hydroxyphenethyl trans-ferulate 具有抗癌活性和血清素能活性。
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GC38995
Panasenoside
Panasenoside 是一种从 Lilium pumilum D. C 分离的类黄酮。 Panasenoside 具有 α-葡萄糖苷酶 (α-glucosidase) 抑制活性。
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GN10011
Rebaudioside A
A natural non-caloric sweetener
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GC61242
Resveratroloside
Resveratroloside是一种α-glucosidase的竞争新抑制剂,能调节血糖水平。Resveratroloside具有心脏保护作用。
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GC34835
Terphenyllin
A fungal metabolite with antibacterial properties
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GC18007
Voglibose
An α-glucosidase inhibitor