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Neuromedin U-25 (human) (trifluoroacetate salt) Sale

(Synonyms: NMU-25) 目录号 : GC47768

A neuropeptide with diverse roles

Neuromedin U-25 (human) (trifluoroacetate salt) Chemical Structure

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500 μg
¥1,679.00
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1 mg
¥2,518.00
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5 mg
¥10,073.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1 Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated roles in vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2 NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.3 NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.4

1.Mitchell, J.D., Maguire, J.J., and Davenport, A.P.Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin SBritish Journal of Pharmacology15887-103(2009) 2.Greenwood, H.C., Bloom, S.R., and Murphy, K.G.Peptides and their potential role in the treatment of diabetes and obesityRev.Diabet.Stud.8(3)355-368(2011) 3.Mitchell, J.D., Maguire, J.J., Kuc, R.E., et al.Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular systemCardiovascular Research81353-361(2009) 4.Alfa, R.W., Park, S., Skelly, K.R., et al.Suppression of insulin production and secretion by a decretin hormoneCell Metabolism21(2)323-333(2015)

Chemical Properties

Cas No. N/A SDF
别名 NMU-25
Canonical SMILES NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])CC3=CC=CC=C3)=O)=O)=O)CC(O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CC5=CC=CC=C5)=O)C)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)CC7=CC=CC=C7)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
分子式 C141H203N41O38.XCF3COOH 分子量 3080.4
溶解度 DMF: 5 mg/ml,DMSO: 1 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.3246 mL 1.6232 mL 3.2463 mL
5 mM 0.0649 mL 0.3246 mL 0.6493 mL
10 mM 0.0325 mL 0.1623 mL 0.3246 mL
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