Gibberellic acid
(Synonyms: 赤霉素; Gibberellin A3) 目录号 : GC38309
Gibberellic acid是一种属于赤霉素类的植物激素，广泛存在于植物中，并且能够促进植物的生长和发育。Gibberellic acid还会诱导大鼠肝肾功能损伤并产生氧化应激。
Cas No.:77-06-5
Sample solution is provided at 25 µL, 10mM.
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Gibberellic acid is a plant hormone belonging to the gibberellins, which are widely present in plants and can promote plant growth and development[1]. Gibberellic acid can also induce liver and kidney dysfunction in rats and generate oxidative stress.
The application of different levels of nitrogen alone and in combination with Gibberellic acid (60g/ha) and the urease inhibitor (NBPT) significantly increased the yield of corn[2]. Gibberellic acid (0.05µM) alleviates cadmium toxicity in rice by regulating NO accumulation and cell wall fixation capacity of cadmium[3]. Gibberellic acid (0 and 0.05μM; 14 days) mitigates nickel stress in soybean by cell wall fixation and regulating oxidative stress metabolism and glyoxalase system[4]. Gibberellic acid (100mg/L; 14 days)-induced generation of hydrogen sulfide alleviates boron toxicity in tomato (Solanum lycopersicum L.) plants[5]. Pre-treatment with Gibberellic acid (600μM; 1h) improved the viability of LPS-stimulated BV2 microglial cells[6].
In animal experiments, Gibberellic acid (5mg/kg; 10 days; i.g.) significantly reduced the expression of multiple inflammatory factors in the hippocampus of sepsis mice[6]. Gibberellic acid (55mg/kg; i.g.) induces dysfunction of liver and kidney and oxidative stress in male albino rats[7].
References:
[1] Huang YP, Chen IH, Kao YS, et al. The gibberellic acid derived from the plastidial MEP pathway is involved in the accumulation of Bamboo mosaic virus. New Phytol. 2022 Aug;235(4):1543-1557.
[2] Ullah I, Dawar K, Tariq M, et al. Gibberellic acid and urease inhibitor optimize nitrogen uptake and yield of maize at varying nitrogen levels under changing climate. Environ Sci Pollut Res Int. 2022 Jan;29(5):6568-6577.
[3] Liu YS, Tao Y, Yang XZ, et al. Gibberellic acid alleviates cadmium toxicity in rice by regulating NO accumulation and cell wall fixation capacity of cadmium. J Hazard Mater. 2022 Oct 5;439:129597.
[4] Bhat JA, Basit F, Alyemeni MN, et al. Gibberellic acid mitigates nickel stress in soybean by cell wall fixation and regulating oxidative stress metabolism and glyoxalase system. Plant Physiol Biochem. 2023 May;198:107678.
[5] Kaya C, Sarıoğlu A, Ashraf M, et al. Gibberellic acid-induced generation of hydrogen sulfide alleviates boron toxicity in tomato (Solanum lycopersicum L.) plants. Plant Physiol Biochem. 2020 Aug;153:53-63.
[6] Xu HJ, Lin YY, Yu JJ, et al. Gibberellic acid targeting ZBTB16 reduces NF-κB dependent inflammatory stress in sepsis-induced neuroinflammation. Eur J Pharmacol. 2024 Aug 5;976:176665.
[7] Soliman MM, Gaber A, Alsanie WF, et al. Gibberellic acid-induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti-inflammatory, and antiapoptotic activities. J Food Biochem. 2022 Feb;46(2):e14069.
Gibberellic acid是一种属于赤霉素类的植物激素，广泛存在于植物中，并且能够促进植物的生长和发育[1]。Gibberellic acid还会诱导大鼠肝肾功能损伤并产生氧化应激。
单独使用不同水平的氮肥以及与Gibberellic acid（60g/ha）和脲酶抑制剂（NBPT）联合使用，显著提高了玉米的产量[2]。Gibberellic acid（0.05µM）通过调节NO积累和镉的细胞壁固定能力，缓解了水稻中的镉毒性[3]。Gibberellic acid（0和0.05µM; 14天）通过细胞壁固定和调节氧化应激代谢及乙二醛酶系统来缓解大豆中的镍胁迫[4]。Gibberellic acid（100mg/L; 14天）诱导的硫化氢生成可缓解番茄（Solanum lycopersicum L.）植株的硼毒性[5]。预先用Gibberellic acid（600µM; 1小时）处理，可提高LPS刺激的BV2小胶质细胞的存活率[6]。
在动物体内实验中，Gibberellic acid（5mg/kg; 10天; 灌胃）显著降低了脓毒症小鼠海马体中多种炎症因子的表达[6]。Gibberellic acid（55mg/kg; 灌胃）在雄性白化大鼠中诱导了肝肾功能障碍和氧化应激[7]。
| Plant experiment [1]: | |
Plant lines | OxABF1–6 and OxABF1–9 (OsABF1 overexpression lines) |
Preparation Method | First, seeds were soaked in a 2% sodium hypochlorite (NaClO, v/v) solution for disinfection. After 20min, the seeds were rinsed with deionized water and then germinated in darkness at 30°C. Subsequently, the seedlings were transferred to 1/2 Kimura B nutrient solution for another 6 days. Finally, uniform seedlings were selected and transferred into the following solutions: complete nutrient solution without cadmium (-Cd), -Cd solution supplemented with 0.05µM Gibberellic acid (GA) (-Cd+Gibberellic acid), solution containing 1µM cadmium (+Cd), +Cd solution with 0.05µM Gibberellic acid (+Cd+Gibberellic acid), +Cd solution with 10µM nitric oxide scavenger cPTIO (+Cd+cPTIO), and +Cd+Gibberellic acid solution with 10µM cPTIO (+Cd+Gibberellic acid+cPTIO). The Gibberellic acid-deficient lines and their wild-type (WT, Nip) seedlings were subjected to -Cd and +Cd solutions for 5 days, after which the seedlings were harvested for analysis. The treatment solutions were changed every two days. |
Reaction Conditions | 0.05µM |
Applications | Gibberellic acid alleviates cadmium toxicity in rice by regulating NO accumulation and cell wall fixation capacity of cadmium. |
| Animal experiment [2]: | |
Animal models | male C57BL/6J mice |
Preparation Method | Mice were randomly divided into four groups (6-8 mice per group) and were administered lipopolysaccharide (LPS) via intraperitoneal injection or Gibberellic acid (GA₃, dissolved in a 1% ethanol solution) via gavage, along with different reagents as follows: control group, saline (8µl/g); Gibberellic acid group, Gibberellic acid (5mg/kg); LPS group, LPS (10mg/kg); LPS + Gibberellic acid group, Gibberellic acid (5mg/kg) + LPS (10mg/kg) dissolved in saline, with LPS injected 60min after Gibberellic acid administration. Mouse survival was monitored for 10 days (n = 20). In a parallel experiment, mice received the same treatments, and their blood and brains were collected at various time points after injection of LPS or saline. Serum and brain tissue samples were stored at −80°C or fixed with formalin for future use. Mice were euthanized by cervical dislocation after intraperitoneal injection of an overdose of 2% pentobarbital sodium (50mg/kg). |
Dosage form | 5mg/kg; 10 days; i.g. |
Applications | Gibberellic acid significantly reduced the expression of multiple inflammatory factors in the hippocampus of sepsis mice. |
References: | |
| Cas No. | 77-06-5 | SDF | |
| 别名 | 赤霉素; Gibberellin A3 | ||
| Canonical SMILES | OC([C@H]1[C@@]([C@]23C)([H])[C@@](OC2=O)(C=C[C@@H]3O)[C@@](CC4)([H])[C@]1(C5)C[C@]4(O)C5=C)=O | ||
| 分子式 | C19H22O6 | 分子量 | 346.37 |
| 溶解度 | DMSO: 250 mg/mL (721.77 mM) | 储存条件 | Store at 2-8°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8871 mL | 14.4354 mL | 28.8709 mL |
| 5 mM | 0.5774 mL | 2.8871 mL | 5.7742 mL |
| 10 mM | 0.2887 mL | 1.4435 mL | 2.8871 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >98.00%
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