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Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) Sale

(Synonyms: Aβ (1-40), Aβ40) 目录号 : GC46850

A neuropeptide with diverse biological activities

Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) Chemical Structure

规格 价格 库存 购买数量
500 μg
¥1,850.00
现货
1 mg
¥3,512.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Amyloid-β (1-40) (Aβ40) peptide is a 40-residue protein fragment of Aβ42 , a neurotoxic peptide found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2 Aβ40 is more abundant, less neurotoxic, and does not form oligomers as easily as Aβ42.3,4 Aβ40 inhibits in vitro fibrillization of Aβ42 in a concentration-dependent manner.5 It also inhibits Aβ42-induced cell death in cultured rat embryonic cortical neurons in a concentration-dependent manner. Aβ40 prevents Aβ42-induced increases in the number of GFAP-positive astrocytes in rat entorhinal cortex.

1.Wolfe, M.S.Therapeutic strategies for Alzheimer's diseaseNat. Rev. Drug Discov.1(11)859-866(2002) 2.Iwatsubo, T., Odaka, A., Suzuki, N., et al.Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron13(1)45-53(1994) 3.Bitan, G., Kirkitadze, M.D., Lomakin, A., et al.Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathwaysProc. Natl. Acad. Sci. USA100(1)330-335(2003) 4.Murphy, M.P., and LeVinne, H., IIIAlzheimer's disease and the β-amyloid peptideJ. Alzheim. Dis.19(1)311(2010) 5.Zou, K., Kim, D., Kakio, A., et al.Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brainJ. Neurochem.87(3)609-619(2003)

Chemical Properties

Cas No. N/A SDF
别名 Aβ (1-40), Aβ40
Canonical SMILES [H]N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(O)=O)=O)CC6=CN=CN6)=O)=O)CC7=CC=CC=C7)=O)=O)C)=O)CC(O)=O.FC(F)(C(O)=O)F
分子式 C194H295N53O58S.XCF3COOH 分子量 4329.8
溶解度 DMSO: 2 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.231 mL 1.1548 mL 2.3096 mL
5 mM 0.0462 mL 0.231 mL 0.4619 mL
10 mM 0.0231 mL 0.1155 mL 0.231 mL
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