Monensin sodium salt
(Synonyms: 莫能菌素钠盐,Monensin A sodium salt) 目录号 : GC16995
Monensin sodium salt是一种聚醚类离子载体抗生素，对多种革兰氏阳性菌具有抗菌活性。Monensin sodium salt用于治疗和预防家禽及其他家畜的球虫病。
Cas No.:22373-78-0
Sample solution is provided at 25 µL, 10mM.
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Monensin sodium salt is a polyether ionophore antibiotic that exhibits antibacterial activity against a variety of Gram-positive bacteria. Monensin sodium salt is used for the treatment and prevention of coccidiosis in poultry and other livestock [1]. Monensin sodium salt is an ionophore that mediates Na+/H+ exchange and is used as a tool to study ionophore mechanisms[2]. Additionally, Monensin sodium salt is an effective inhibitor of Wnt signaling[3]. Monensin sodium salt also has the potential to inhibit cancer development[4].
In vitro, treatment of human colorectal cancer cells RKO and HCT-116 with Monensin sodium salt (4μM) significantly inhibits cell proliferation, migration, and cell cycle progression, while inducing apoptosis and G1 arrest. Moreover, Monensin sodium salt can suppress the expression of IGF1R by increasing the expression of IGF1[5]. Monensin sodium salt (0.1–10μM) treatment of human peripheral blood eosinophils for 2 hours induces apoptosis-like cell death, with minimal effects on neutrophils[6].
In vivo, Monensin sodium salt (1mg/kg) was administered intraperitoneally to BALB/c mice sensitized with house dust mite (HDM) for 6 weeks. Monensin sodium salt significantly reduced the infiltration of eosinophils and lymphocytes into the airway lumen and decreased the lung tissue inflammation score[7]. Monensin sodium salt (10mg/kg) was administered intraperitoneally in a xenograft tumor model established with the pancreatic cancer cell line Panc-1. Monensin sodium salt significantly inhibited tumor growth, reduced tumor volume, and decreased the expression of proliferating cell nuclear antigen (PCNA) and epidermal growth factor receptor (EGFR) in the tumor tissues[8].
References:
[1] Rajendran V, Ilamathi HS, Dutt S, et al. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent. Curr Top Med Chem. 2018;18(22):1976-1986.
[2] Dias SADN, Divyasorubini S, Gamage KTJ, et al. Na+/K+ carrier ionophore antibiotics valinomycin and monensin enhance the antibacterial activity of fluoride. J Antibiot (Tokyo). 2023 Jul;76(7):425-429.
[3] Fu B, Fang L, Wang R, et al. Inhibition of Wnt/β-catenin signaling by monensin in cervical cancer. Korean J Physiol Pharmacol. 2024 Jan 1;28(1):21-30.
[4] Markowska A, Kaysiewicz J, Markowska J, et al. Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1549-1554.
[5] Zhou Y, Deng Y, Wang J, et al. Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 Dec;55(1):954-964.
[6] Vraila M, Asp E, Melo FR, et al. Monensin induces secretory granule-mediated cell death in eosinophils. J Allergy Clin Immunol. 2023 Nov;152(5):1312-1320.e3.
[7] Allam VSRR, Akula S, Waern I, et al. Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice. Inflammation. 2025 Apr;48(2):806-819.
[8] Wang X, Wu X, Zhang Z, et al. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep. 2018 Dec 17;8(1):17914.
Monensin sodium salt是一种聚醚类离子载体抗生素，对多种革兰氏阳性菌具有抗菌活性。Monensin sodium salt用于治疗和预防家禽及其他家畜的球虫病[1]。Monensin sodium salt是一种介导Na+/H+交换的离子载体，被用于研究离子载体机制的工具[2]。此外，Monensin sodium salt是一种有效的Wnt信号传导抑制剂[3]。Monensin sodium salt还具备抑制癌症发展的作用 [4]。
Monensin sodium salt是一种聚醚类离子载体抗生素，对多种革兰氏阳性菌具有抗菌活性。Monensin sodium salt用于治疗和预防家禽及其他家畜的球虫病[1]。Monensin sodium salt是一种介导Na+/H+交换的离子载体，被用于研究离子载体机制的工具[2]。此外，Monensin sodium salt是一种有效的Wnt信号传导抑制剂[3]。Monensin sodium salt还具备抑制癌症发展的作用 [4]。
在体外，Monensin sodium salt（4μM）处理人结直肠癌细胞RKO和HCT-116，Monensin sodium salt显著抑制细胞增殖、迁移以及细胞周期进程，并诱导细胞凋亡和G1期阻滞。此外，Monensin sodium salt还可通过增加IGF1的表达来抑制IGF1R的表达[5]。Monensin sodium salt（0.1–10μM）处理人外周血嗜酸性粒细胞2小时，可诱导细胞凋亡样死亡，而对中性粒细胞影响较小[6]。
在体内，Monensin sodium salt（1mg/kg）通过腹腔注射给药，用于处理经屋尘螨（HDM）致敏的BALB/c小鼠，持续6周。Monensin sodium salt显著减少了嗜酸性粒细胞和淋巴细胞向气道腔的浸润，降低了肺组织炎症评分[7]。Monensin sodium salt（10mg/kg）通过腹腔注射给药，用于处理胰腺癌细胞系Panc-1建立的裸鼠皮下移植瘤模型。Monensin sodium salt显著抑制了移植瘤的生长，降低了肿瘤体积，并减少了肿瘤组织中增殖细胞核抗原（PCNA）和表皮生长因子受体（EGFR）的表达[8]。
| Cell experiment [1]: | |
Cell lines | Human colorectal cancer cell lines RKO and HCT-116 |
Preparation Method | RKO and HCT-116 cells were maintained in complete Dulbecco's Modified Eagle's Medium (DMEM) containing 10% fetal bovine serum (FBS), 100 units of penicillin, and 100μg of streptomycin at 37°C in a humidified atmosphere with 5% CO₂. Cells were treated with varied concentrations of Monensin sodium salt (0–8μM) for 24–48 hours. |
Reaction Conditions | 0–8μM; 24–48h. |
Applications | Monensin sodium salt effectively inhibited cell proliferation and migration in a dose-dependent and time-dependent manner. Monensin sodium salt also induced apoptosis and G1 arrest in both cell lines. Monensin sodium salt targeted multiple cancer-related signaling pathways, including Elk1, AP1, and Myc/max, and suppressed IGF1R expression via increasing IGF1 in colorectal cancer cells. |
| Animal experiment [2]: | |
Animal models | Nude mice |
Preparation Method | Firefly luciferase-tagged Panc-1 cells were subcutaneously injected into the flanks of athymic nude mice. After 3 days, the mice were randomly divided into two groups and treated with Monensin sodium salt (10mg/kg) or vehicle control. Tumor progression was monitored through whole body Xenogen bioluminescence imaging at 7, 11, 16, and 26 days post-treatment. Mice were sacrificed after 4 weeks. |
Dosage form | 10mg/kg; i.p. |
Applications | Monensin effectively suppressed tumor growth, reduced tumor volume, and decreased the expression of the cell proliferation marker PCNA and EGFR in the tumor samples. |
References: | |
| Cas No. | 22373-78-0 | SDF | |
| 别名 | 莫能菌素钠盐,Monensin A sodium salt | ||
| Canonical SMILES | O[C@H]1C[C@]2(O[C@H]([C@H](C)[C@@H]([C@@H](C([O-])=O)C)OC)[C@@H]1C)O[C@@](CC2)(C)[C@@H]3O[C@](CC3)(CC)[C@H]4O[C@H]([C@H]([C@@H](C)C[C@H]5C)O[C@]5(CO)O)C[C@H]4C.[Na+] | ||
| 分子式 | C36H61NaO11 | 分子量 | 692.85 |
| 溶解度 | ≥ 69.3mg/mL in EtOH with ultrasonic, <6.93mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4433 mL | 7.2166 mL | 14.4331 mL |
| 5 mM | 0.2887 mL | 1.4433 mL | 2.8866 mL |
| 10 mM | 0.1443 mL | 0.7217 mL | 1.4433 mL |
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| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
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| % DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
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2.
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Quality Control & SDS
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- Purity: >98.00%
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