Stigmasterol glucoside
(Synonyms: 豆甾醇葡萄糖苷) 目录号 : GC37691
Stigmasterol glucoside 是从 P. urinaria 分离出的一种甾醇，具有高抗氧化和高抗炎活性，能作为抑制剂 5α-reductase 的抑制剂，IC50 值为 27.2 ?M。
Cas No.:19716-26-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Stigmasterol glucoside is a sterol isolated from P. urinaria with high antioxidant and anti-inflammatory activities[1], act as an inhibitor of 5α-reductase with an IC50 of 27.2 µM[2]. IC50:27.2 µM (5α-reductase)[2]
[1]. Musarat Amina, et al. Sequential injection-chemiluminescence evaluation of stigmasterol glucoside and luteolin via green synthesis of silver nanoparticles using biomass of plectranthus asirensis. 2018, Nov 09, 11(4): 523-533. [2]. Kamei H, et al. Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase. Biol Pharm Bull. 2018;41(8):1307-1310.
| Cas No. | 19716-26-8 | SDF | |
| 别名 | 豆甾醇葡萄糖苷 | ||
| Canonical SMILES | OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@@]1([H])O[C@H](C2)CC[C@@]3(C)C2=CC[C@]4([H])[C@]3([H])CC[C@@]5(C)[C@]4(CC[C@]5([H])[C@H](C)/C=C/[C@@H](CC)C(C)C)[H] | ||
| 分子式 | C35H58O6 | 分子量 | 574.83 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7396 mL | 8.6982 mL | 17.3964 mL |
| 5 mM | 0.3479 mL | 1.7396 mL | 3.4793 mL |
| 10 mM | 0.174 mL | 0.8698 mL | 1.7396 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Effects of Fermentation Conditions Using Lactobacillus plantarum on the Charantin, Stigmasterol glucoside and β-sitosterol Glucoside Contents of Bitter Gourd (Momordica charantia L.) Juice
Plant Foods Hum Nutr 2020 Dec;75(4):656-658.PMID:33009632DOI:10.1007/s11130-020-00860-w.
Bitter gourd fruits contain high amounts of charantin, Stigmasterol glucoside and β-sitosterol glucoside, which have been shown to provide health benefits for humans. However, the bitterness of the fruit means they are rarely consumed. This study aimed to assess the effects of Lactobacillus plantarum fermentation, which has previously been reported to effectively reduce bitterness, on the contents of these compounds. The current results suggest that Lactobacillus plantarum fermentation should be considered as a potential approach to enhance the levels of these compounds in bitter gourd juice.
Secondary metabolites from Detarium microcarpum Guill. and Perr. (Fabaceae)
Z Naturforsch C J Biosci 2022 Feb 23;77(5-6):253-261.PMID:35212491DOI:10.1515/znc-2021-0239.
The chemical investigation of the ethanol/water (7:3) extract of the roots of Detarium microcarpum (Fabaceae) led to the isolation of one new labdane diterpenoid, microcarpin (1) and one new ceramide derivative, microcarpamide (2), along with eight known secondary metabolites (3-10) including, 5-(carboxymethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid (3), microcarposide (4), rhinocerotinoic acid (5), 1,7-dihydroxy-6-methylxanthone (6), ursolic acid (7), 3β,23-dihydroxylup-20(29)-en-28-oic acid (8), alphitolic acid (9), and Stigmasterol glucoside (10). The structures of these compounds were elucidated based on their spectroscopic data. Although compounds 3 and 4 are known, their crystalline structures are reported here for the first time. These compounds were evaluated in vitro for their antisalmonella activity. The results obtained showed that, microcarpamide (2), microcarposide (4), and rhinocerotinoic acid (5) were moderately active against three salmonella strains: Salmonella typhi, Salmonella enteritidis and Salmonella typhimirium, with minimum inhibition concentration values of 76.7 and 153.5 μM.
Withanolides from Withania somnifera roots
Phytochemistry 2008 Feb;69(4):1000-4.PMID:18061221DOI:10.1016/j.phytochem.2007.10.024.
Two new and seven known withanolides along with beta-sitosterol, stigmasterol, beta-sitosterol glucoside, Stigmasterol glucoside, alpha+beta glucose were isolated from the roots of Withania somnifera. Among the known compounds, Viscosa lactone B, stigmasterol, Stigmasterol glucoside and alpha+beta glucose are being reported from the roots of W. somnifera for the first time. One of the new compounds contained the rare 16beta-acetoxy-17(20)-ene the other contained unusual 6alpha-hydroxy-5,7alpha-epoxy functional groups in the withasteroid skeleton. The structures were elucidated by spectroscopic methods and chemical transformations.
Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase
Biol Pharm Bull 2018;41(8):1307-1310.PMID:30068884DOI:10.1248/bpb.b18-00283.
In our research program to find novel agents for alopecia from natural plant resources, we screened Euphorbiaceae plant extracts using an anti-5α-reductase assay. Among the samples tested, the extract of Phyllanthus urinaria showed the most potent activity with 24.3 and 64.6% inhibition at 50 and 200 µg/mL against the enzyme, respectively. The extract also suppressed the androgen activity of dihydrotestosterone in LNCaP cell line. These results show that the extract of P. urinaria may be a multi-potent agent for androgen-derived alopecia. We tested for activity on a hair regrowth model using mice. The extract of P. urinaria showed hair regrowth activity at 5 mg/mouse/d administration. Furthermore, the active principle for anti-5α-reductase activity was determined as Stigmasterol glucoside from activity-guided fractionation and the IC50 was 27.2 µM. These results suggest that extract of P. urinaria may be a promising candidate anti-alopecia agent.
Simultaneous analysis of free phytosterols and phytosterol glycosides in rice bran by SPE/GC-MS
Food Chem 2022 Sep 1;387:132742.PMID:35398677DOI:10.1016/j.foodchem.2022.132742.
In this study, free phytosterols and phytosterol glycosides in rice bran were successfully separated and analyzed using solid-phase extraction (SPE) combined with gas chromatography-mass spectrometry (GC-MS). The results showed that free phytosterols in rice bran included ergosterol (129 ± 8 μg/g rice bran), campesterol (126 ± 9 μg/g rice bran), stigmasterol (106 ± 9 μg/g rice bran), β-sitosterol (305 ± 10 μg/g rice bran), cycloartenol (80.5 ± 3.9 μg/g rice bran) and 24-methylenecycloartenol (87.1 ± 2.2 μg/g rice bran), while phytosterol glycosides included campesterol glucoside (16.0 ± 1.3 μg/g rice bran), Stigmasterol glucoside (99.0 ± 4.9 μg/g rice bran) and β-sitosterol glucoside (133 ± 7 μg/g rice bran). The methodological validation indicated that this method could accurately quantify free phytosterols and phytosterol glycosides in rice bran. This study provided a new direction to establish a rapid and simple method for the simultaneous determination of different forms of phytosterols in foods.