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Emamectin Benzoate Sale

(Synonyms: 甲胺基阿维菌素苯甲酸盐; MK-244) 目录号 : GC35975

Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.

Emamectin Benzoate Chemical Structure

Cas No.:155569-91-8

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10mM (in 1mL DMSO)
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100mg
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500mg
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产品描述

Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.

[1] Mohamed A Kandil, et al. J Econ Entomol. 2020 Feb 8;113(1):385-389. [2] Shaorong Luan, et al. Chem Biol Interact. 2017 Aug 1;273:90-98.

Chemical Properties

Cas No. 155569-91-8 SDF
别名 甲胺基阿维菌素苯甲酸盐; MK-244
分子式 C56H81NO15 分子量 1008.24
溶解度 DMSO: ≥ 31 mg/mL (16.49 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 0.9918 mL 4.9591 mL 9.9183 mL
5 mM 0.1984 mL 0.9918 mL 1.9837 mL
10 mM 0.0992 mL 0.4959 mL 0.9918 mL
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Research Update

Dissipation of Emamectin Benzoate Residues in Rice and Rice-Growing Environments

Molecules 2020 Jan 23;25(3):483.PMID:31979297DOI:10.3390/molecules25030483.

The experiment developed the ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) method for testing Emamectin Benzoate, and studied the metabolism of Emamectin Benzoate in rice plants and rice-growing environments via application of this testing method. The dissipation curve of Emamectin Benzoate standard substance was good at 0.5-200 μg L-1, and its correlation coefficient was greater than 0.99. In the concentration range of 0.1-50 μg kg-1, the average recovery rate of plants, soil, and field water was 82 %-102 %, and relative standard deviation (RSD) was between 0.3 % and 15.9 %. Half-lives in rice plants and soil were 0.8-2.8 days and 1.9-3.8 days, respectively, and Emamectin Benzoate was not detected in rice or rice hull. The experiment showed that Emamectin Benzoate is harmless to human health at the concentration recommended by the manufacturer.

Emamectin Benzoate nanogel suspension constructed from poly(vinyl alcohol)-valine derivatives and lignosulfonate enhanced insecticidal efficacy

Colloids Surf B Biointerfaces 2022 Jan;209(Pt 1):112166.PMID:34739877DOI:10.1016/j.colsurfb.2021.112166.

To reduce the negative impact of nanopesticide carriers of on the environment, a greener nanodelivery system is necessary. Nanogels are nontoxic and degradable carriers, however, the potential of nanogels for delivering pesticides has not been proven. In this study, poly(vinyl alcohol)-valine, an ecofriendly polymer, was synthesized and used to fabricate Emamectin Benzoate nanogel suspension (EB NS). The nanoformulation showed favorable stability at low temperature, high temperature or one year storage, and in water with different hardnesses. The retention of the EB NS solution on leaves was higher than that of an EB emulsifiable concentrate (EC) by approximately 9% at a concentration of 10 mg L-1. The half-life of EB nanogels under Ultra Violet irradiation was prolonged by 3.3-fold. Moreover, the bioactivity of the EB NS against Plutella xylostella was higher than that of the EB EC. These advantages resulted in a relatively long duration of pest control. The response of nanogels to laccase, a digestive enzyme in the digestive tract of lepidopteran pests, enables pesticide release on demand. Nanogels have the advantages of being ecofriendly carriers, exhibiting higher utilization, and prolonged pest control periods, and they have a brilliant future in pesticide delivery.

An accidental Emamectin Benzoate poisoning in child: A case report

Clin Case Rep 2022 Jul 25;10(7):e6133.PMID:35898734DOI:10.1002/ccr3.6133.

We report a case of accidental Emamectin Benzoate poisoning in a six-year-old child resulting in nausea, vomiting, abdominal pain, and confusion. We did vigorous gastric lavage with saline, activated charcoal, and coconut oil. The other supportive treatment improved the outcome of the patient with complete resolution of symptoms.

Emamectin Benzoate as a potential molluscicide against white garden snail, Theba pisana in association with biochemical defects

Pest Manag Sci 2022 Apr;78(4):1657-1664.PMID:34989113DOI:10.1002/ps.6785.

Background: The white garden snail, Theba pisana, is distributed worldwide and is a serious molluscan pest of different crops. Emamectin Benzoate (EMB) 'an avermectin derivative' is a novel biorational agent and highly effective pesticide. This study focused on the lethal and in vivo sublethal toxic effect of EMB on the energy reserves (glycogen, lipids and proteins), total energy reserves and activities of glutathione S-transferase (GST), γ-glutamyl transferase (γ-GT), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the hepatopancreas of T. pisana for up to 7 days of exposure. Results: The median lethal dose (LD50 ) at 48 h of EMB treatment was 5.34 μg g-1 body weight (b.w.). Sublethal doses of 1.07 and 3.20 μg g-1 b.w. (i.e., 20% and 60% of the LD50 ) led to significant dose- and time-dependent decreases in glycogen and lipids; these doses increased the total protein level. Overall, the tested sublethal doses significantly decreased the total energy reserves. Moreover, GST and γ-GT activities were elevated, whereas the activities of AST and ALT were inhibited in the exposed snails. A decrease in LDH activity after 1 and 3 days of exposure and an increase after 7 days of exposure were seen in snails treated with EMB. Conclusion: EMB exerted lethal toxicity on T. pisana and consequently caused changes in energy reserve levels and enzyme activities in the animal. © 2022 Society of Chemical Industry.

Sublethal effects and reproductive hormesis of Emamectin Benzoate on Plutella xylostella

Front Physiol 2022 Oct 19;13:1025959.PMID:36338483DOI:10.3389/fphys.2022.1025959.

The diamondback moth (DBM), Plutella xylostella L., is an important pest of cruciferous vegetables, and population control mainly depends on chemical pesticides. Emamectin Benzoate is a highly effective insecticide used for controlling DBM. However, it is unknown how the sublethal effects of low concentration residues of Emamectin Benzoate on DBM. So the population development sublethal effects of Emamectin Benzoate, at LC5, LC10, and LC20 with concentrations of 0.014 mg/L, 0.024 mg/L and 0.047 mg/L, respectively, on adult DBM and their progeny were investigated in this study. The pupal weight, pupal period, female fecundity, and vitellin content of the F0 DBM generation increased significantly compared to the control. And the single female oviposition number of DBM was increased by 20.21% with LC20 treatment. The pupation rate, adult longevity and ovariole length of the treatment groups decreased significantly. The fecundity of DBM in the treatment groups increased, and this increased the population by a presumptive 13.84%. Treatment also led to the shortening of ovarioles and the reduction of egg hatching, and increased pupal weight in the F1 generation. We concluded that the effects of sublethal/low concentration Emamectin Benzoate on the different life stages of DBM were variable, and the reproductive hormesis on DBM adults were attractive findings.