Fluroxypyr-meptyl
(Synonyms: 氟草烟1-甲基庚基酯,Fluroxypyr-1-methylheptyl ester) 目录号 : GC61428
Fluroxypyr-meptyl(Fluroxypyr-1-methylheptylester)是一种合成植物激素，被用作除草剂。
Cas No.:81406-37-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fluroxypyr-meptyl (Fluroxypyr-1-methylheptyl ester), a synthetical phytohormone, is used as herbicide agent[1][2].
[1]. Wang L, et, al. Dissipation and residues of fluroxypyr-meptyl in rice and environment. Bull Environ Contam Toxicol. 2011 Apr;86(4):449-53. [2]. Hewitt PG, et, al. Metabolism of fluroxypyr, fluroxypyr methyl ester, and the herbicide fluroxypyr methylheptyl ester. II: in rat skin homogenates. Drug Metab Dispos. 2000 Jul;28(7):755-9.
| Cas No. | 81406-37-3 | SDF | |
| 别名 | 氟草烟1-甲基庚基酯,Fluroxypyr-1-methylheptyl ester | ||
| Canonical SMILES | O=C(OC(C)CCCCCC)COC1=NC(F)=C(Cl)C(N)=C1Cl | ||
| 分子式 | C15H21Cl2FN2O3 | 分子量 | 367.24 |
| 溶解度 | DMSO: 100 mg/mL (272.30 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.723 mL | 13.6151 mL | 27.2301 mL |
| 5 mM | 0.5446 mL | 2.723 mL | 5.446 mL |
| 10 mM | 0.2723 mL | 1.3615 mL | 2.723 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Dissipation and residues of Fluroxypyr-meptyl in rice and environment
Bull Environ Contam Toxicol 2011 Apr;86(4):449-53.PMID:21340457DOI:10.1007/s00128-011-0218-y.
A simple and reliable analytical method for analysis of Fluroxypyr-meptyl residue in rice, soil and water was investigated. The residue levels and dissipation rates of Fluroxypyr-meptyl (34% AS) were determined by GC-MSD in selected ion monitoring mode. In the supervised field trials, the half-life of fluroxypyr- meptyl in rice plant was in the range 1.25-4.13 days. The half-lives of Fluroxypyr-meptyl in soil and water were 2.29 and 1.73 days, respectively. In order to assess the dissipation of Fluroxypyr-meptyl in the environment, a laboratory simulated experiment was carried out in soil and water. The terminal residues of Fluroxypyr-meptyl in rice plant, husked rice, rice hull and soil samples were undetectable at harvest. It showed that Fluroxypyr-meptyl may be safe to use according to the recommended dosage suggested by the corporation.
A case of fatal intoxication by ingestion of an herbicide formulation containing Fluroxypyr-meptyl and triclopyr
Forensic Sci Int 2021 Mar;320:110717.PMID:33578180DOI:10.1016/j.forsciint.2021.110717.
Fluroxypyr-meptyl and triclopyr are synthetic auxin-like herbicides that are used to control woody and broadleaf weeds. Herein, we report a case of fatal intoxication involving Fluroxypyr-meptyl and triclopyr. A 61-year-old man was found dead at his farm with several suicide notes, and a white plastic bottle and a plastic cup with traces of white emulsion were found next to him. The plastic bottle was labeled as an herbicide formulation containing Fluroxypyr-meptyl and triclopyr. Forensic toxicological screening of the stomach contents revealed the presence of Fluroxypyr-meptyl, fluroxypyr and triclopyr. However, no Fluroxypyr-meptyl was detected in blood owing to its rapid hydrolysis to fluroxypyr. In this study, fluroxypyr and triclopyr in blood were extracted using solid-phase extraction, and analyzed by liquid chromatography-tandem mass spectrometry. The analytical method was validated in terms of linearity, precision, accuracy, recovery and matrix effect, and the acceptable criteria were satisfied. Toxicological analysis showed that fluroxypyr and triclopyr concentrations were 19.7 μg/mL and 137.4 μg/mL in peripheral blood and 16.5 μg/mL and 147.8 μg/mL in heart blood, respectively. Based on these toxicological results and autopsy findings, the cause of death was determined to be acute fatal intoxication by ingestion of the pesticide containing Fluroxypyr-meptyl and triclopyr. This is the first report of the determination of fluroxypyr and triclopyr in a fatal intoxication case.
Weather dependent dynamics of the herbicides florasulam, carfentrazone-ethyl, Fluroxypyr-meptyl and fluroxypyr in wheat fields through field studies and computational simulation
Chemosphere 2016 Dec;165:320-328.PMID:27664521DOI:10.1016/j.chemosphere.2016.09.026.
A dynamic model of dynamiCROP was applied to study environmental fate and behavior of four herbicides in wheat including florasulam, carfentrazone-ethyl, Fluroxypyr-meptyl, and fluroxypyr. Meantime, their residue in wheat and dissipation half-lives in plant determined by field trials using QuEChERS liquid chromatography tandem mass spectrometry were used to verify modelling results. The combination of experimental verification and modelling prediction deciphered the fate of four pesticides in wheat field ecosystem. Besides, temperature difference of 3 °C only resulted in lower than 15% half-life difference. By quantifying the contribution of temperature, the predominant role of rain on pesticide dissipation was highlighted for the first time, namely higher precipitation leaded to faster degradation and vice versa.
Evaluation of confirmatory data following the Article 12 MRL review for fluroxypyr
EFSA J 2019 Sep 17;17(9):e05816.PMID:32626434DOI:10.2903/j.efsa.2019.5816.
The applicant Dow AgroSciences submitted a request to the competent national authority in Germany to evaluate the confirmatory data that were identified for fluroxypyr in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gaps, a method of analysis for plant matrices, information on metabolism in onions, revised Good Agricultural Practices (GAPs) and reside trials on apples, onions and grass, argumentation regarding the efficiency of the hydrolysis step and information on storage stability in plant matrices and products of animal origin were submitted. A ruminant metabolism study with Fluroxypyr-meptyl was available and evaluated. Toxicological information on metabolites identified in the ruminant metabolism study (i.e. fluroxypyr pyridinol and its conjugates) is required to derive a final residue definition for livestock. EFSA recommends reconsideration of the existing MRLs for several plant and animal commodities.
Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro
Arch Toxicol 2021 Oct;95(10):3205-3221.PMID:34417632DOI:10.1007/s00204-021-03140-x.
Currently, the authorisation process for plant protection products (PPPs) relies on the testing of acute and topological toxicity only. Contrastingly, the evaluation of active substances includes a more comprehensive set of toxicity studies. Nevertheless, mixture effects of active ingredients and co-formulants may result in increased toxicity. Therefore, we investigated effects of surface active co-formulants on the toxicity of two PPPs focussing on qualitative and quantitative toxicokinetic effects on absorption and secretion. The respective products are based on the active substances abamectin and Fluroxypyr-meptyl and were tested for cytotoxicity in the presence or absence of the corresponding surfactants and co-formulants using Caco-2 cells. In addition, the effect of co-formulants on increased cellular permeation was quantified using LC-MS/MS, while potential kinetic mixture effects were addressed by fluorescence anisotropy measurements and ATPase assays. The results show that surface active co-formulants significantly increase the cytotoxicity of the investigated PPPs, leading to more than additive mixture effects. Moreover, analytical investigations show higher efflux ratios of both active substances and the metabolite fluroxypyr upon combination with certain concentrations of the surfactants. The results further point to a significant and concentration-dependent inhibition of Pgp transporters by most of the surfactants as well as to increased membrane fluidity. Altogether, these findings strongly support the hypothesis that surfactants contribute to increased cytotoxicity of PPPs and do so by increasing the bioavailability of the respective active substances.