Ferulic acid sodium (Sodium ferulate)
(Synonyms: 阿魏酸钠; Coniferic acid sodium) 目录号 : GC32439
A phenol with diverse biological activities
Cas No.:24276-84-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ferulic acid is a phenol that has been found in apples and has diverse biological activities.1,2,3,4 It is active against the yeast S. cerevisiae when used at a concentration of 250 ppm and the bacteria E. coli, S. aureus, and B. cereus when used at a concentration of 500 ?g/ml.1,2 Dietary administration of ferulic acid (0.2% w/w) reduces serum total cholesterol levels in a rat model of diet-induced hypercholesterolemia.3 It suppresses benzo(a)pyrene-induced forestomach tumor formation in mice.4
1.Baranowski, J.D., Davidson, P.M., Nagel, C.W., et al.Inhibition of Saccharomyces cerevisiae by naturally occurring hydroxycinnamatesJ. Food Sci.45(3)592-594(1980) 2.Herald, P.J., and Davidson, P.M.Antibacterial activity of selected hydroxycinnamic acidsJ. Food Sci.48(4)1378-1379(1983) 3.Sharma, R.D.Effect of hydroxy acids on hypercholesterolaemia in ratsAtherosclerosis37(3)463-468(1980) 4.Wattenburg, L.W., Coccia, J.B., and Lam, L.K.Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasiaCancer Res.40(8 Pt 1)2820-2823(1980)
| Cas No. | 24276-84-4 | SDF | |
| 别名 | 阿魏酸钠; Coniferic acid sodium | ||
| Canonical SMILES | [O-]C(/C=C/C1=CC=C(O)C(OC)=C1)=O.[Na+] | ||
| 分子式 | C10H9NaO4 | 分子量 | 216.17 |
| 溶解度 | DMSO : 16.6 mg/mL (76.79 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.626 mL | 23.1299 mL | 46.2599 mL |
| 5 mM | 0.9252 mL | 4.626 mL | 9.252 mL |
| 10 mM | 0.4626 mL | 2.313 mL | 4.626 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders
Neurochem Res 2021 May;46(5):1043-1057.PMID:33547615DOI:10.1007/s11064-021-03257-6.
Ferulic acid is being screened in preclinical settings to combat various neurological disorders. It is a naturally occurring dietary flavonoid commonly found in grains, fruits, and vegetables such as rice, wheat, oats, tomatoes, sweet corn etc., which exhibits protective effects against a number of neurological diseases such as epilepsy, depression, ischemia-reperfusion injury, Alzheimer's disease, and Parkinson's disease. Ferulic acid prevents and treats different neurological diseases pertaining to its potent anti-oxidative and anti-inflammatory effects, beside modulating unique neuro-signaling pathways. It stays in the bloodstream for longer periods than other dietary polyphenols and antioxidants and easily crosses blood brain barrier. The use of novel drug delivery systems such as solid-lipid nanoparticles (SLNs) or its salt forms (Sodium ferulate, ethyl ferulate, and isopentyl ferulate) further enhance its bioavailability and cerebral penetration. Based on reported studies, ferulic acid appears to be a promising molecule for treatment of neurological disorders; however, more preclinical (in vitro and in vivo) mechanism-based studies should be planned and conceived followed by its testing in clinical settings.
Synchronous fluorescence determination of ferulic acid with Ce(IV) and sodium tripolyphosphate
Luminescence 2014 May;29(3):243-7.PMID:23744595DOI:10.1002/bio.2535.
In this study, a synchronous fluorescence detection method for ferulic acid (FA) is proposed based on a redox reaction between FA and Ce(IV) sulfate in dilute sulfuric acid medium at room temperature. It was found that FA could reduce Ce(IV) to Ce(III) in acidic medium, and sodium tripolyphosphate could further enhance the intrinsic fluorescence of the Ce(III) produced. The enhanced extent of synchronous fluorescence intensity was in proportion to the concentration of FA over the range 3.0 脳 10(-8) to 1.0 脳 10(-5) mol/L. The corresponding limit of determination (S/N = 3) was 1.3 脳 10(-8) mol/L. The proposed method was applied to the determination of Sodium ferulate for injection sample with satisfactory results.
Ferulic acid increases intestinal Lactobacillus and improves cardiac function in TAC mice
Biomed Pharmacother 2019 Dec;120:109482.PMID:31568990DOI:10.1016/j.biopha.2019.109482.
Ferulic acid, a main ingredient of Ligusticum, exhibits anti-oxidant and anti-inflammation effects in heart diseases. Some studies indicate that gut microbiome is associated with the generation of ferulic acid. Whether the beneficial effect of ferulic is raised by the alteration of gut microbiota is still unknown. This study examined the effect of Sodium ferulate on gut microbiome and cardiac function in TAC mice. Cell Counting Kit-8 (CCK8) assay verified that ferulic acid has low toxicity in vitro and that ferulic acid inhibited the up-regulation of 尾-MHC and ANP induced by Angiotensin II. In addition, daily supplement of 50 mg/kg Sodium ferulate improved the ejection fraction and changed the gut microbiota composition of TAC mice. Relative abundance of Lactobacillus and Parabacteroides are increased in TAC mice gavaged with Sodium ferulate. In addition, Lactobacillus is negatively correlated with HW/BW and LW/BW ratio. These results suggest that the beneficial effect of ferulic in TAC mice is probably through the regulation of gut microbiota.
Sodium ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment
Oxid Med Cell Longev 2018 Jul 8;2018:4967318.PMID:30116483DOI:10.1155/2018/4967318.
The introduction of intracameral anaesthesia by injection of lidocaine has become popular in cataract surgery for its inherent potency, rapid onset, tissue penetration, and efficiency. However, intracameral lidocaine causes corneal thickening, opacification, and corneal endothelial cell loss. Herein, we investigated the effects of lidocaine combined with Sodium ferulate, an antioxidant with antiapoptotic and anti-inflammatory properties, on lidocaine-induced damage of corneal endothelia with in vitro experiment of morphological changes and cell viability of cultured human corneal endothelial cells and in vivo investigation of corneal endothelial cell density and central corneal thickness of cat eyes. Our finding indicates that Sodium ferulate from 25 to 200 mg/L significantly reduced 2 g/L lidocaine-induced toxicity to human corneal endothelial cells, and 50 mg/L Sodium ferulate recovered the damaged human corneal endothelial cells to normal growth status. Furthermore, 100 mg/L Sodium ferulate significantly inhibited lidocaine-induced corneal endothelial cell loss and corneal thickening in cat eyes. In conclusion, Sodium ferulate protects human corneal endothelial cells from lidocaine-induced cytotoxicity and attenuates corneal endothelial cell loss and central corneal thickening of cat eyes after intracameral injection with lidocaine. It is likely that the antioxidant effect of Sodium ferulate reduces the cytotoxic and inflammatory corneal reaction during intracameral anaesthesia.
Sodium ferulate inhibits neointimal hyperplasia in rat balloon injury model
PLoS One 2014 Jan 29;9(1):e87561.PMID:24489938DOI:10.1371/journal.pone.0087561.
Background/aim: Neointimal formation after vessel injury is a complex process involving multiple cellular and molecular processes. Inhibition of intimal hyperplasia plays an important role in preventing proliferative vascular diseases, such as restenosis. In this study, we intended to identify whether Sodium ferulate could inhibit neointimal formation and further explore potential mechanisms involved. Methods: Cultured vascular smooth muscle cells (VSMCs) isolated from rat thoracic aorta were pre-treated with 200 碌mol/L Sodium ferulate for 1 hour and then stimulated with 1 碌mol/L angiotensin II (Ang II) for 1 hour or 10% serum for 48 hours. Male Sprague-Dawley rats subjected to balloon catheter insertion were administrated with 200 mg/kg Sodium ferulate (or saline) for 7 days before sacrificed. Results: In presence of Sodium ferulate, VSMCs exhibited decreased proliferation and migration, suppressed intracellular reactive oxidative species production and NADPH oxidase activity, increased SOD activation and down-regulated p38 phosphorylation compared to Ang II-stimulated alone. Meanwhile, VSMCs treated with Sodium ferulate showed significantly increased protein expression of smooth muscle 伪-actin and smooth muscle myosin heavy chain protein. The components of Notch pathway, including nuclear Notch-1 protein, Jagged-1, Hey-1 and Hey-2 mRNA, as well as total 尾-catenin protein and Cyclin D1 mRNA of Wnt signaling, were all significantly decreased by Sodium ferulate in cells under serum stimulation. The levels of serum 8-iso-PGF2伪 and arterial collagen formation in vessel wall were decreased, while the expression of contractile markers was increased in Sodium ferulate treated rats. A decline of neointimal area, as well as lower ratio of intimal to medial area was observed in Sodium ferulate group. Conclusion: Sodium ferulate attenuated neointimal hyperplasia through suppressing oxidative stress and phenotypic switching of VSMCs.