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CTSL Human

目录号 : GP21507

Cathepsin-L Human Recombinant

CTSL Human Chemical Structure

规格 价格 库存 购买数量
5μg
¥840.00
5-10工作日
20μg
¥2,030.00
5-10工作日
1mg
¥37,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

CTSL Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 339 amino acids (18-333 a.a) andhaving a molecular mass of 38.3kDa.CTSL is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

Product Data

Purity Greaterthan 90% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile Filtered clear solution. Shipping Condition Shipped with Ice Packs.
Synonyms Cathepsin L; CTSL1; Cathepsin L1; Major Excreted Protein;MEP; EC 3.4.22.15; CATL; EC 3.4.22.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSTLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV.
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Formulation CTSL protein solution (1mg/ml) containing 20mM Tris-HCl (pH 8.0) and10% glycerol.

Introduction

Cathepsin-L also known as CTSL is a member of the peptidase C1 family.CTSL, is a dimer composed of disulfide-linked heavy and light chains, bothformed from a single protein precursor. Furthermore, CTSL is a lysosomalcysteine proteinase which takes a main part in intracellular proteincatabolism. CTSL substrates include collagen and elastin, as well as alpha-1protease inhibitor, which is the most important controlling element ofneutrophil elastase activity. CTSL has been implicated in a number of pathologicprocesses, including myofibril necrosis in myopathies and in myocardialischemia, and in the renal tubular response to proteinuria. Multiplealternatively spliced transcript variants have been found for CTSL.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.