Chlormidazole hydrochloride
(Synonyms: Clomidazole hydrochloride) 目录号 : GC39601
Chlormidazole hydrochloride 是一种抗真菌剂 ( antifungal agent)，对多种真菌和部分革兰氏阳性球菌有抑制活性。Chlormidazole hydrochloride 可用于指甲和皮肤的真菌和细菌感染，包括指间和甲周真菌。
Cas No.:74298-63-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses[1].
[1]. Daniel J. Sheehan, et al. Current and Emerging Azole Antifungal Agents. Clin Microbiol Rev. 1999 Jan; 12(1): 40-79.
| Cas No. | 74298-63-8 | SDF | |
| 别名 | Clomidazole hydrochloride | ||
| Canonical SMILES | CC1=NC2=CC=CC=C2N1CC3=CC=C(Cl)C=C3.[H]Cl | ||
| 分子式 | C15H14Cl2N2 | 分子量 | 293.19 |
| 溶解度 | DMSO: 62.5 mg/mL (213.17 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4108 mL | 17.0538 mL | 34.1076 mL |
| 5 mM | 0.6822 mL | 3.4108 mL | 6.8215 mL |
| 10 mM | 0.3411 mL | 1.7054 mL | 3.4108 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Sensitivity of aerobic bacteria and Candida species to Chlormidazole hydrochloride in vitro]
Pol Tyg Lek 1990 Jan;45(4-5):91-2.PMID:2395759doi
Over 100 bacterial stains, including Candida sp., gram-positive cocci and some gram-negative bacilli, were tested. The majority of microorganisms was isolated from man. Only one bacterial strain (5 micrograms/mL) and 76% of Candida strains were sensitive to chlormidazole HCl (10 micrograms/mL). It may be assumed that most infections with Candida sp. will respond to therapy with drugs containing chlormidazole HCl. Relatively simple and inexpensive tube test may serve to evaluate microbial sensitivity to this agent, especially in case of isolates from patients.