Search results for: 'Peptide'

Cat.No. 产品名称 Information

GP10049 Amyloid Beta-Peptide (12-28) (human)

淀粉-Β-蛋白片段12-28,Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys

Amyloid Beta-Peptide (12-28)（人）是 Amyloid Beta 蛋白 (1-42) (Aβ (1-42)) 的肽片段。

GP10094 Amyloid β-peptide (10-35), amide

H2N-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2

Truncated peptide model

GP10118 Amyloid Beta-Peptide (1-40) (human)

BETA淀粉样蛋白片段1-40,Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

淀粉样蛋白 Beta-Peptide (1-40)（人）是一种主要蛋白质，存在于阿尔茨海默病患者大脑中的斑块中。's 病。

GP10082 Amyloid Beta-peptide (25-35) (human)

BETA-淀粉样蛋白片断25-35,Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

淀粉样蛋白β肽(Aβ) (25-35)(human)是阿尔茨海默病淀粉样蛋白β肽的片段，具有神经毒性作用。

GC45382 Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Aβ (1-28), Aβ28

A 28-residue amyloid-β protein fragment

GC35334 Amyloid β Peptide (42-1)(human)

淀粉Β-蛋白(42-1),Amyloid β Peptide (42-1)(human)

淀粉样蛋白 β Peptide (42-1)(human) 是淀粉样蛋白 β 的无活性形式；肽 (1-42)。

GP10057 Amyloid β-Peptide (10-20) (human)

Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe

Amyloid β-Peptide (10-20) (human) 是 Amyloid-&#946 的片段；肽，可用于神经系统疾病的研究。

GC43650 FAM-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)

FAM-Aβ (1-40), FAM-Aβ40

A fluorescently labeled amyloid-β peptide

GC42798 Amyloid-β (1-38) Peptide (trifluoroacetate salt)

β-Amyloid (1-38), Aβ38, Aβ (1-38)

A peptide fragment of Aβ42

GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Aβ (1-42), Aβ42

A 42-amino acid protein fragment of amyloid-β

GC46850 Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)

Aβ (1-40), Aβ40

A neuropeptide with diverse biological activities

GC42803 Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

Aβ (25-35)

An 11-residue amyloid-β protein fragment

GC42799 Amyloid-β (17-40) Peptide (human) (trifluoroacetate salt)

Aβ (17-40)

A 24-residue amyloid-β protein fragment

GC40127 Amyloid-β (22-35) Peptide (trifluoroacetate salt)

Aβ (22-35)

A 13-residue amyloid-β protein fragment

GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

TAMRA-Aβ42, TAMRA-Aβ (1-42)

A fluorescently labeled amyloid-β peptide

GC44986 TAMRA-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

TAMRA-Aβ (1-28), TAMRA-Aβ28

A fluorescently labeled amyloid-β peptide

GC42505 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) A fluorescently tagged peptide

GC40160 Biotin-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Biotin-Aβ (1-28), Biotin-Aβ28

A biotinylated amyloid-β peptide

GC40130 5-FAM-Amyloid-β (1-42) Peptide (human) (trifluoroacetate salt)

5-FAM-Aβ (1-42), 5-FAM-Aβ42

A fluorescently labeled amyloid-β peptide

GC40128 TAMRA-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)

TAMRA-Aβ (1-40), TAMRA-Aβ40

A fluorescently labeled amyloid-β peptide

GC45465 Glp-Amyloid-β (3-40) Peptide (human) (trifluoroacetate salt)

AβN3(pE)-40, AβpE3-40, Glp-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

A peptide fragment of amyloid-β

GC35335 Amyloid β-peptide (1-40) rat

β淀粉样肽(1-40)(鼠)

淀粉样蛋白 ⋲-肽 (1-40) 大鼠是淀粉样蛋白 β-肽的大鼠形式，它作为不溶性细胞外沉积物积聚在神经元周围，导致与阿尔茨海默病 (AD) 相关的老年斑。

GC42804 Amyloid-β (40-1) Peptide (human) (trifluoroacetate salt)

Aβ (40-1)

An inactive control peptide for amyloid-β (1-40)

GC42801 Amyloid-β (1-8) Peptide

Aβ (1-8)

A wild-type control for amyloid-β (1-8, A2V) peptide

GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Biotin-Aβ (1-42), Biotin-Aβ42

An affinity probe for Aβ42 binding partners

GC42802 Amyloid-β (1-8, A2V) Peptide

Aβ (1-8, A2V), Aβ (1-8) mutant, Amyloid-β (1-8) dominant negative

A truncated form of Aβ containing the A2V mutation

GC42800 Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt)

Aβ (17-42), LVFFAEDVGSNKGAIIGLMVGGVVIA

A 26-residue amyloid-β protein fragment

GC40129 Biotin-Amyloid-β (1-40) Peptide (trifluoroacetate salt)

Biotin-Aβ (1-40), Biotin-Aβ40

An affinity probe for Aβ40 binding partners

GC40126 Amyloid-β Precursor Protein (96-110) Peptide (cyclized) (human) (trifluoroacetate salt)

Cyclized APP (96-110), Cyclized APP96-110

A 15-residue cyclized APP fragment

GC61988 β-amyloid (12-28) (TFA)

Amyloid β-Protein (12-28) (TFA); Amyloid Beta-Peptide (12-28) (human) TFA; β-Amyloid protein fragment(12-28) TFA

β-amyloid (12-28) TFA 是 β-淀粉样蛋白 (β1-42) 的肽片段。 β1-42 是 42 个氨基酸的蛋白质，是老年斑核心的主要成分。β-amyloid (12-28) 具有聚集特性。β-amyloid (12-28) 有潜力用于阿尔茨海默氏病的研究。

GC37984 β-Amyloid (1-42), rat

Amyloid β-peptide (1-42) (rat/mouse)

β-Amyloid (1-42), rat 是一种 42-aa 肽，对急性海马切片有细胞毒作用，用于研究老年痴呆症's disease。

GA21423 ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]) This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 . 10?² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM). It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures.

GC16243 β-Amyloid (1-42), human TFA

大豆肽

淀粉样蛋白 β 肽 (1-42) 人 TFA 是一种由 42 个氨基酸组成的肽。

GA20182 (Gln²²)-Amyloid β-Protein (1-40) The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.

GA20739 Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.

GA20727 Amyloid β-Protein (1-39) Small quantities of Aβ37, 38 and 39 can be detected in CSF together with Aβ40, the most abundant Aβ homolog, Aβ42, and N-terminally truncated amyloid peptides. The relative amounts depend on the variant of Alzheimer's disease. The C-terminally truncated amyloid peptides are also found in amyloid plaques.

GA20720 Amyloid β-Protein (10-35) Amyloid β-protein (10-35), YEVHHQKLVFFAEDVGSNKGAIIGLM, was used as a truncated peptide model for the full-length amyloid β-proteins (1-40) and (1-42) in high-resolution structural studies. In contrast to the full-length amyloid β-proteins, amyloid β-protein (10-35) allowed the controlled and reproducible formation of homogeneous fibrils from aqueous solutions of defined pH, ionic strength and soluble peptide concentration necessary for high-resolution structural studies.

GA20535 Acetyl-Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.

GA20533 Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)

乙酰基-淀粉样肽Β/A4蛋白质前体770(APP)(96-110)(环化)

This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²?I-labeled APP to heparin (IC??= 10??M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.

GA20284 (Pyr³)-Amyloid β-Protein (3-42)

(PYR3)-淀粉Β-蛋白

(Pyr³)-Amyloid β-Protein (3-42) was found to be the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. Therefore, (Pyr³)-Aβ (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated Aβ sequence.

GA20030 (Arg⁶)-Amyloid β-Protein (1-40) The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His? by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.

GA20024 (7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40) Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (Λex = 430 nm, Λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.

GA23601 Teplow's Amyloid β-Protein (1-42) (scrambled II) This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.

GA23600 Teplow's Amyloid β-Protein (1-40) (scrambled II) This peptide is a specifically designed negative control in studies with Abeta40. It is "scrambled", which means it contains the same amino acids as Abeta40, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-40) does not show a number of phenomena regularly observed with Abeta40 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.

GA23175 Mca-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.

GA21424 ent-Amyloid β-Protein (1-42) All-D Aβ (1-42) exhibits similar properites as the all-L Aβ. The peptide forms ion channels in lipid bilayers.

GA20748 Amyloid β-Protein (3-42) The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate.

GA20744 Amyloid β-Protein (2-42) Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages.

GA20742 Amyloid β-Protein (17-40) Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.

GA20738 Amyloid β-Protein (1-6) Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice.

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